Zobrazeno 1 - 10
of 13
pro vyhledávání: '"K. Trent Moreland"'
Autor:
John T. Petroff, Noah M. Dietzen, Ezry Santiago-McRae, Brett Deng, Maya S. Washington, Lawrence J. Chen, K. Trent Moreland, Zengqin Deng, Michael Rau, James A. J. Fitzpatrick, Peng Yuan, Thomas T. Joseph, Jérôme Hénin, Grace Brannigan, Wayland W. L. Cheng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Pentameric ligand-gated ion channels are modulated by anionic phospholipids. Here, by capturing an open-channel conformation of ELIC, the authors demonstrate the structural details of channel activation and a leaflet-specific mechanism for modulation
Externí odkaz:
https://doaj.org/article/d772e49e78fb4be7aa7a408b799d12f0
Autor:
Noah M Dietzen, Mark J Arcario, Lawrence J Chen, John T Petroff II, K Trent Moreland, Kathiresan Krishnan, Grace Brannigan, Douglas F Covey, Wayland WL Cheng
Publikováno v:
eLife, Vol 11 (2022)
Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well understood. The PUFA, docosahexaenoic acid (DHA), inhibits agonist responses of the pLGIC, ELIC, more effectively th
Externí odkaz:
https://doaj.org/article/28bf0dd55ae64ba8b05cd03aeee35398
Autor:
John T. Petroff, Noah M. Deitzen, Ezry Santiago-McRae, Brett Deng, Maya S. Washington, Lawrence J. Chen, K. Trent Moreland, Zengqin Deng, Michael Rau, James A. J. Fitzpatrick, Peng Yuan, Thomas T. Joseph, Jérôme Hénin, Grace Brannigan, Wayland W. L. Cheng
Pentameric ligand-gated ion channels (pLGICs) mediate synaptic transmission and are sensitive to their lipid environment. The mechanism of phospholipid modulation of any pLGIC is not well understood. We demonstrate that the model pLGIC, ELIC (Erwinia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d864e4b461367a9fb673545413db7b5e
https://doi.org/10.1101/2022.06.07.494883
https://doi.org/10.1101/2022.06.07.494883
Autor:
Mark J Arcario, Noah M Dietzen, Lawrence J Chen, John T Petroff, K Trent Moreland, Kathiresan Krishnan, Grace Brannigan, Douglas F Covey, Wayland WL Cheng
Publikováno v:
eLife
eLife, Vol 11 (2022)
eLife, Vol 11 (2022)
Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well understood. The PUFA, docosahexaenoic acid (DHA), inhibits agonist responses of the pLGIC, ELIC, more effectively th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d685f704e707a9b71c453cae825aba31
http://europepmc.org/articles/PMC8786314
http://europepmc.org/articles/PMC8786314
Autor:
Mark J Arcario, Noah M Dietzen, Lawrence J Chen, John T Petroff, K Trent Moreland, Kathiresan Krishnan, Grace Brannigan, Douglas F Covey, Wayland WL Cheng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca2f7e54db11ecbcbb1e697a84484769
https://doi.org/10.7554/elife.74306.sa2
https://doi.org/10.7554/elife.74306.sa2
Autor:
K Trent Moreland, Mina Hong, Wenfu Lu, Christopher W Rowley, David M Ornitz, James J De Yoreo, Ruediger Thalmann
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95333 (2014)
Otoconia are formed embryonically and are instrumental in detecting linear acceleration and gravity. Degeneration and fragmentation of otoconia in elderly patients leads to imbalance resulting in higher frequency of falls that are positively correlat
Externí odkaz:
https://doaj.org/article/9d1cf55c2016451b86addde4a1339fb5
Autor:
H. Henry Teng, Mina Hong, James J. De Yoreo, K. Trent Moreland, Ruediger Thalmann, Jiajun Chen
Publikováno v:
Crystal Growth & Design
We investigated the roles of three proteins associated with the formation of otoconia including fetuin A, osteopontin (OPN), and otoconin 90 (OC90). In situ atomic force microscopy (AFM) studies of the effects of these proteins on the growth of atomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54134f431c3b54c976724fb2dc0cb7e1
https://doi.org/10.1021/cg501001r
https://doi.org/10.1021/cg501001r
Akademický článek
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Autor:
Andrew J. Lonigro, Alan H. Stephenson, Jennifer L. Iverson, Randy S. Sprague, Jesse D Procknow, K. Trent Moreland
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:446-454
Epoxyeicosatrienoic acids (EETs) have been reported to contract intralobar pulmonary arteries (PA) of the rabbit in a cyclooxygenase (COX)-dependent manner. In the present study, we observed that COX-1 and COX-2 isoforms were expressed in freshly iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952f2dd79852907fe3efbd005c3fd68e
https://doi.org/10.1124/jpet.106.107904
https://doi.org/10.1124/jpet.106.107904
Autor:
Mina Hong, James J. De Yoreo, Ruediger Thalmann, David M. Ornitz, Christopher W. Rowley, K. Trent Moreland, Wenfu Lu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e95333 (2014)
PLoS ONE, Vol 9, Iss 4, p e95333 (2014)
Otoconia are formed embryonically and are instrumental in detecting linear acceleration and gravity. Degeneration and fragmentation of otoconia in elderly patients leads to imbalance resulting in higher frequency of falls that are positively correlat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8bb81f8f47a635a5432394b04dc06c
https://pubmed.ncbi.nlm.nih.gov/24748133
https://pubmed.ncbi.nlm.nih.gov/24748133