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Akademický článek

Pharmacological or genetic inhibition of iNOS prevents cachexia‐mediated muscle wasting and its associated metabolism defects

Autor: Jason Sadek, Derek T Hall, Bianca Colalillo, Amr Omer, Anne‐Marie K Tremblay, Virginie Sanguin‐Gendreau, William Muller, Sergio Di Marco, Marco Emilio Bianchi, Imed‐Eddine Gallouzi

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 7, Pp 1-24 (2021)

Abstract Cachexia syndrome develops in patients with diseases such as cancer and sepsis and is characterized by progressive muscle wasting. While iNOS is one of the main effectors of cachexia, its mechanism of action and whether it could be targeted

Externí odkaz: https://doaj.org/article/50ee8d2abc6a43eda880e459f9956f4e

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Akademický článek

Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy

Autor: Brenda Janice Sánchez, Anne-Marie K. Tremblay, Jean-Philippe Leduc-Gaudet, Derek T. Hall, Erzsebet Kovacs, Jennifer F. Ma, Souad Mubaid, Patricia L. Hallauer, Brittany L. Phillips, Katherine E. Vest, Anita H. Corbett, Dimitris L. Kontoyiannis, Sabah N. A. Hussain, Kenneth E. M. Hastings, Sergio Di Marco, Imed-Eddine Gallouzi

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

HuR is an RNA-binding protein that regulates myotube differentiation in vitro. Here, the authors show that the muscle-specific ablation of HuR in mice leads to enhanced endurance capacity and an increase in oxidative fibres by destabilising PGC1α-mR

Externí odkaz: https://doaj.org/article/abbd8d839dcd49f5a47e7010f27a777f

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Akademický článek

Tracking Inhibitory Control in Youth With ADHD: A Multi-Modal Neuroimaging Approach

Autor: Lescia K. Tremblay, Christopher Hammill, Stephanie H. Ameis, Mehereen Bhaijiwala, Donald J. Mabbott, Evdokia Anagnostou, Jason P. Lerch, Russell J. Schachar

Publikováno v: Frontiers in Psychiatry, Vol 11 (2020)

BackgroundA decreased ability to inhibit a speeded motor response is a well-studied deficit in Attention Deficit Hyperactivity Disorder (ADHD), and has been proposed as an endophenotype. Inhibitory control has been assessed reliably with the Stop Sig

Externí odkaz: https://doaj.org/article/fcf1d3800a3e4fc78a1c1a1552dd5285

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Akademický článek

The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

Autor: Derek T Hall, Takla Griss, Jennifer F Ma, Brenda Janice Sanchez, Jason Sadek, Anne Marie K Tremblay, Souad Mubaid, Amr Omer, Rebecca J Ford, Nathalie Bedard, Arnim Pause, Simon S Wing, Sergio Di Marco, Gregory R Steinberg, Russell G Jones, Imed‐Eddine Gallouzi

Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 7, Pp 1-23 (2018)

Abstract Activation of AMPK has been associated with pro‐atrophic signaling in muscle. However, AMPK also has anti‐inflammatory effects, suggesting that in cachexia, a syndrome of inflammatory‐driven muscle wasting, AMPK activation could be ben

Externí odkaz: https://doaj.org/article/a8b3c211642c4712934b7dbd386af718

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Akademický článek

STAT3 promotes IFNγ/TNFα‐induced muscle wasting in an NF‐κB‐dependent and IL‐6‐independent manner

Autor: Jennifer F Ma, Brenda J Sanchez, Derek T Hall, Anne‐Marie K Tremblay, Sergio Di Marco, Imed‐Eddine Gallouzi

Publikováno v: EMBO Molecular Medicine, Vol 9, Iss 5, Pp 622-637 (2017)

Abstract Cachexia is a debilitating syndrome characterized by involuntary muscle wasting that is triggered at the late stage of many cancers. While the multifactorial nature of this syndrome and the implication of cytokines such as IL‐6, IFNγ, and

Externí odkaz: https://doaj.org/article/1142ed7c4ec943f98c82b9c403012518

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Akademický článek

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Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy

Autor: Sergio Di Marco, Jean-Philippe Leduc-Gaudet, Jennifer F. Ma, Imed-Eddine Gallouzi, Erzsébet Nagy Kovács, Brittany L. Phillips, Anne-Marie K. Tremblay, Patricia L. Hallauer, Kenneth E. M. Hastings, Dimitris L. Kontoyiannis, Souad Mubaid, Derek T Hall, Brenda Janice Sanchez, Sabah N. A. Hussain, Katherine E. Vest, Anita H. Corbett

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications

The master posttranscriptional regulator HuR promotes muscle fiber formation in cultured muscle cells. However, its impact on muscle physiology and function in vivo is still unclear. Here, we show that muscle-specific HuR knockout (muHuR-KO) mice hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215c2cbd621f6d91ed16c6cb8a4fb812
http://link.springer.com/article/10.1038/s41467-019-12186-6

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Pharmacological or genetic inhibition of iNOS prevents cachexia‐mediated muscle wasting and its associated metabolism defects

Autor: Marco Bianchi, Bianca Colalillo, Amr Omer, Sergio Di Marco, William J. Muller, Jason Sadek, Imed-Eddine Gallouzi, Anne-Marie K. Tremblay, Virginie Sanguin-Gendreau, Derek T Hall

Publikováno v: EMBO Molecular Medicine

Cachexia syndrome develops in patients with diseases such as cancer and sepsis and is characterized by progressive muscle wasting. While iNOS is one of the main effectors of cachexia, its mechanism of action and whether it could be targeted for thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a195e48ec4ebe0cc9cc9b657340896b3
https://doi.org/10.15252/emmm.202013591

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The CLAS12 superconducting magnets

Publikováno v: Nucl.Instrum.Meth.A
Nucl.Instrum.Meth.A, 2020, 962, pp.163578. ⟨10.1016/j.nima.2020.163578⟩

International audience; As part of the Jefferson Lab 12 GeV upgrade, the Hall B CLAS12 system requires two superconducting iron-free magnets — a torus and a solenoid. The physics requirements to maximize space for the detectors guided engineers tow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ed4d3152ce6101cba8939ac993eab6
https://hal.archives-ouvertes.fr/hal-02527031

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