Zobrazeno 1 - 5
of 5
pro vyhledávání: '"K. Tao Pun"'
Autor:
Alison E. John, Rebecca H. Graves, K. Tao Pun, Giovanni Vitulli, Ellen J. Forty, Paul F. Mercer, Josie L. Morrell, John W. Barrett, Rebecca F. Rogers, Maryam Hafeji, Lloyd I. Bibby, Elaine Gower, Valerie S. Morrison, Yim Man, James A. Roper, Jeni C. Luckett, Lee A. Borthwick, Ben S. Barksby, Rachel A. Burgoyne, Rory Barnes, Joelle Le, David J. Flint, Susan Pyne, Anthony Habgood, Louise A. Organ, Chitra Joseph, Rochelle C. Edwards-Pritchard, Toby M. Maher, Andrew J. Fisher, Natasja Stæhr Gudmann, Diana J. Leeming, Rachel C. Chambers, Pauline T. Lukey, Richard P. Marshall, Simon J. F. Macdonald, R. Gisli Jenkins, Robert J. Slack
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The αvβ6 integrin is key in activating the pro-fibrotic cytokine TGFβ in idiopathic pulmonary fibrosis. Here, the authors show an inhaled small molecule αvβ6 inhibitor GSK3008348 induces prolonged inhibition of TGFβ signaling pathways in human
Externí odkaz:
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
Autor:
Natasja Stæhr Gudmann, Richard P. Marshall, Jeni Luckett, Rebecca F. Rogers, Robert J. Slack, Simon J. F. Macdonald, Diana Julie Leeming, Rachel C. Chambers, Joelle Le, Pauline T. Lukey, Anthony Habgood, Paul F. Mercer, Rachel A. Burgoyne, Ben S. Barksby, Lloyd I. Bibby, Yim Man, Maryam Hafeji, Andrew J. Fisher, David J. Flint, Toby M. Maher, Louise Organ, Susan Pyne, Lee A. Borthwick, James A. Roper, Valerie S. Morrison, Alison E. John, Giovanni Vitulli, Rebecca H. Graves, Rochelle C. Edwards-Pritchard, R. Gisli Jenkins, John Barrett, Josie Morrell, K. Tao Pun, Elaine Gower, Rory Barnes, Ellen J. Forty, Chitra Joseph
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The αvβ6 integrin plays a key role in the activation of transforming growth factor-β (TGFβ), a pro-fibrotic mediator that is pivotal to the development of idiopathic pulmonary fibrosis (IPF). We identified a selective small molecule αvβ6 RGD-mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b4959cf67302e9783a88dddd530b0b
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
Autor:
Panayiotis A. Procopiou, Simon J. F. Macdonald, Ben S. Barksby, Jeni Luckett, Richard P. Marshall, Yim Man, Valerie S. Morrison, Lee A. Borthwick, Alex L Wilkinson, R. Gisli Jenkins, Elaine Gower, Rory Barnes, Alison E. John, Richard J. D. Hatley, John Barrett, K. Tao Pun, James A. Roper, Tim N. Barrett, Andrew J. Fisher, Robert J. Slack, Rachel A. Burgoyne
Publikováno v:
European journal of pharmacology. 913
Fibrosis is the formation of scar tissue due to injury or long-term inflammation and is a leading cause of morbidity and mortality. Activation of the pro-fibrotic cytokine transforming growth factor-β (TGFβ) via the alpha-V beta-6 (αvβ6) integrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab5aeaeda70ec0b5bdd8dacee1a7937
https://pubmed.ncbi.nlm.nih.gov/34762934
https://pubmed.ncbi.nlm.nih.gov/34762934
Autor:
Syedia R. Rahman, James A. Roper, Jane I. Grove, Guruprasad P. Aithal, K. Tao Pun, Andrew J. Bennett
Publikováno v:
Liver international : official journal of the International Association for the Study of the LiverREFERENCES. 42(3)
As the worldwide prevalence of chronic liver diseases is high and continuing to increase, there is an urgent need for treatment to prevent cirrhosis-related morbidity and mortality. Integrins are heterodimeric cell-surface proteins that are promising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8532814e56af19b600ff4f57f0f54b28
https://pubmed.ncbi.nlm.nih.gov/35048542
https://pubmed.ncbi.nlm.nih.gov/35048542
Autor:
Robert J. Shaw, Matthew C. Catley, Kerryn McCluskie, Tony J. Savage, Jorge De Alba, Clarissa J. Watts, Robert Newton, Saleem Haj-Yahia, Maria G. Belvisi, K. Tao Pun, Sissie Wong, Mark A. Birrell, Elizabeth Hardaker
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 172:962-971
Rationale Nuclear factor (NF)-kappaB is a transcription factor known to regulate the expression of many inflammatory genes, including cytokines, chemokines, and adhesion molecules. NF-kappaB is held inactive in the cytoplasm, bound to I-kappaB. The r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b495be1872993bfd4b63684ccd8a4a38
https://doi.org/10.1164/rccm.200412-1647oc
https://doi.org/10.1164/rccm.200412-1647oc