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Akademický článek

Metabolic regulation by the intestinal metformin-AMPK axis

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-3 (2022)

AMP-activated protein kinase (AMPK) mediates the glucose-lowering effect of the antidiabetic agent metformin, but the sites of action remain unclear. In the March issue of Nature Communications, Zhang and colleagues reported that intestinal epitheliu

Externí odkaz: https://doaj.org/article/9bda580c853842f69b7ec4e4552ea866

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Akademický článek

The metabolic impact of small intestinal nutrient sensing

Autor: Frank A. Duca, T. M. Zaved Waise, Willem T. Peppler, Tony K. T. Lam

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

The gastrointestinal tract participates in maintaining metabolic homeostasis in part through nutrient-sensing and subsequent gut-brain signalling. Here the authors review the role of small intestinal nutrient-sensing in regulation of energy intake an

Externí odkaz: https://doaj.org/article/a95c8ae22f0042f1b3ef962d4051972d

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Akademický článek

Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production

Autor: T. M. Zaved Waise, Mozhgan Rasti, Frank A. Duca, Song-Yang Zhang, Paige V. Bauer, Christopher J. Rhodes, Tony K. T. Lam

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

The mechanistic target of rapamycin (TOR) functions as an energy sensor and contributes to the control of glucose homeostasis. Here, the authors show that mTOR in the upper small intestine regulates hepatic glucose production and is required for the

Externí odkaz: https://doaj.org/article/ed627460bddc4b5ba603759563251b83

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Akademický článek

Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing

Autor: Helen J. Dranse, T. M. Zaved Waise, Sophie C. Hamr, Paige V. Bauer, Mona A. Abraham, Brittany A. Rasmussen, Tony K. T. Lam

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

High protein diets are known to improve metabolic parameters including adiposity and glucose homeostasis. Here the authors demonstrate that preabsorptive upper small intestinal protein-sensing mechanisms mediated by peptide transporter 1 improve gluc

Externí odkaz: https://doaj.org/article/2f568c4cce01458e9f67dd6472addf49

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Akademický článek

Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity

Autor: Jessica T. Y. Yue, Mona A. Abraham, Paige V. Bauer, Mary P. LaPierre, Peili Wang, Frank A. Duca, Beatrice M. Filippi, Owen Chan, Tony K. T. Lam

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)

Glycine sensing in the dorsal vagal complex (DVC) regulates hepatic glucose production in rodents. Here the authors show that pharmacological and molecular inhibition of glycine reuptake in the DVC potentiates NMDA receptors, and improves metabolic h

Externí odkaz: https://doaj.org/article/39518d1b32d94bf387969a5e946ba9b7

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