Zobrazeno 1 - 10
of 41
pro vyhledávání: '"K. Syam Krishnan"'
Autor:
Carrie L. Shaffer, James A. D. Good, Santosh Kumar, K. Syam Krishnan, Jennifer A. Gaddy, John T. Loh, Joseph Chappell, Fredrik Almqvist, Timothy L. Cover, Maria Hadjifrangiskou
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT Bacteria utilize complex type IV secretion systems (T4SSs) to translocate diverse effector proteins or DNA into target cells. Despite the importance of T4SSs in bacterial pathogenesis, the mechanism by which these translocation machineries d
Externí odkaz:
https://doaj.org/article/15bbd8d36f9e457eba73abb71a8f3410
Autor:
Patrik Engström, K. Syam Krishnan, Bidong D. Ngyuen, Erik Chorell, Johan Normark, Jim Silver, Robert J. Bastidas, Matthew D. Welch, Scott J. Hultgren, Hans Wolf-Watz, Raphael H. Valdivia, Fredrik Almqvist, Sven Bergström
Publikováno v:
mBio, Vol 6, Iss 1 (2015)
ABSTRACT In a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120. A fluorescent KSK120 analogue was synthesized and observed to be associated with the
Externí odkaz:
https://doaj.org/article/00303facf7d845949d710878fb025781
Autor:
Martina Kulén, Christer Larsson, Fredrik Almqvist, K. Syam Krishnan, Erik Chorell, James A. D. Good, Mette R. Hansen, Gregory A. Harrison, Dennis X. Zhu, Jonathan Livny, Scott J. Hultgren, Kelly Flentie, Christina L. Stallings, Anders E. G. Lindgren, Leslie A. Weiss, Torbjörn Wixe, Hasan Tükenmez, Andrew G. Cairns, Christoffer Bengtsson, Souvik Sarkar, Samantha D. Solomon, Miranda E. Schene, Rachel L. Kinsella
Publikováno v:
Proceedings of the National Academy of Sciences. 116:10510-10517
Mycobacterium tuberculosis ( Mtb ) killed more people in 2017 than any other single infectious agent. This dangerous pathogen is able to withstand stresses imposed by the immune system and tolerate exposure to antibiotics, resulting in persistent inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fc38cc536017cb4fd2b8f71cbd16357
https://doi.org/10.1073/pnas.1818009116
https://doi.org/10.1073/pnas.1818009116
Autor:
Kelly, Flentie, Gregory A, Harrison, Hasan, Tükenmez, Jonathan, Livny, James A D, Good, Souvik, Sarkar, Dennis X, Zhu, Rachel L, Kinsella, Leslie A, Weiss, Samantha D, Solomon, Miranda E, Schene, Mette R, Hansen, Andrew G, Cairns, Martina, Kulén, Torbjörn, Wixe, Anders E G, Lindgren, Erik, Chorell, Christoffer, Bengtsson, K Syam, Krishnan, Scott J, Hultgren, Christer, Larsson, Fredrik, Almqvist, Christina L, Stallings
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(21)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f95775346e9eccdc954e92cd619078b
https://pubmed.ncbi.nlm.nih.gov/31176512
https://pubmed.ncbi.nlm.nih.gov/31176512
Autor:
Afshan Begum, Christin Grundström, Erik Chorell, Sabine Hansen, Christopher Andersson, Moritz S. Niemiec, Fredrik Almqvist, A. Elisabeth Sauer-Eriksson, James A. D. Good, Pernilla Wittung-Stafshede, Jessica Wall, Uwe Sauer, K. Syam Krishnan, Karolis Vaitkevicius, Jörgen Johansson
Publikováno v:
Cell Chemical Biology
Summary The transcriptional activator PrfA, a member of the Crp/Fnr family, controls the expression of some key virulence factors necessary for infection by the human bacterial pathogen Listeria monocytogenes. Phenotypic screening identified ring-fus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58674b1cdc7e5721780d36acdcec1be3
http://europepmc.org/articles/PMC4802734
http://europepmc.org/articles/PMC4802734
Autor:
Olli Salin, Patrik Engström, Wael Bahnan, Åsa Gylfe, James A. D. Good, Fredrik Almqvist, Sven Bergström, Carlos Núñez-Otero, K. Syam Krishnan, Richard Svensson, Jim Silver, Per Artursson
Publikováno v:
Journal of Medicinal Chemistry. 59:2094-2108
The bacterial pathogen Chlamydia trachomatis is a global health burden currently treated with broad-spectrum antibiotics which disrupt commensal bacteria. We recently identified a compound through phenotypic screening that blocked infectivity of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f62725a446ad67d1430ec5dc5033545
https://doi.org/10.1021/acs.jmedchem.5b01759
https://doi.org/10.1021/acs.jmedchem.5b01759
Autor:
Åsa Gylfe, Esmee de Groot, Fredrik Almqvist, Emma Wede, Martina Kulén, Carlos Núñez-Otero, Jim Silver, K. Syam Krishnan, Wael Bahnan, James A. D. Good, Ingela Nilsson, Sven Bergström
Publikováno v:
Journal of medicinal chemistry. 60(22)
Chlamydia trachomatis is a global health burden due to its prevalence as a sexually transmitted disease and as the causative agent of the eye infection trachoma. We recently discovered 3-amido thiazolino 2-pyridones which attenuated C. trachomatis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1faf7f81534f7f6ea89bf88028a31d1b
https://pubmed.ncbi.nlm.nih.gov/29053275
https://pubmed.ncbi.nlm.nih.gov/29053275
Autor:
Kokkuvayil Vasu Radhakrishnan, Shyam Chand, Vijay Nair, Preethanuj Preethalayam, Jomy Joseph, Sreeja Thulasi, K. Syam Krishnan, Florian Jaroschik
Publikováno v:
Chemical Reviews
Chemical Reviews, American Chemical Society, 2017, 117 (5), pp.3930-3989. ⟨10.1021/acs.chemrev.6b00210⟩
Chemical Reviews, American Chemical Society, 2017, 117 (5), pp.3930-3989. ⟨10.1021/acs.chemrev.6b00210⟩
International audience; Pentafulvenes are a unique class of compounds that originally attractedattention due to their propensity to display nonbenzenoid aromaticity. Subsequently,they were recognized as valuable synthons for the construction of a wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1cba1ef80437547fe7bae6f68c892fc
https://hal.archives-ouvertes.fr/hal-01990575
https://hal.archives-ouvertes.fr/hal-01990575
Autor:
K. Syam Krishnan, Pardeep Singh, Fredrik Almqvist, Erik Chorell, Joergen Aaden, Tomas Kindahl, Pernilla Wittung-Stafshede
Publikováno v:
ChemInform. 47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b629f17ae4d182c8b08c09e67bb18c26
https://doi.org/10.1002/chin.201619148
https://doi.org/10.1002/chin.201619148
Autor:
John T. Loh, Santosh Kumar, Jennifer A. Gaddy, Maria Hadjifrangiskou, K. Syam Krishnan, Joseph Chappell, James A. D. Good, Timothy L. Cover, Fredrik Almqvist, Carrie L. Shaffer
Publikováno v:
mBio
mBio, Vol 7, Iss 2 (2016)
mBio, Vol 7, Iss 2, p e00221-16 (2016)
mBio, Vol 7, Iss 2 (2016)
mBio, Vol 7, Iss 2, p e00221-16 (2016)
Bacteria utilize complex type IV secretion systems (T4SSs) to translocate diverse effector proteins or DNA into target cells. Despite the importance of T4SSs in bacterial pathogenesis, the mechanism by which these translocation machineries deliver ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fac5df06eba302cef44bb63aaa15946
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-124000
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-124000