Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence

Autor: Q. Heydt, C. Xintaropoulou, A. Clear, M. Austin, I. Pislariu, F. Miraki-Moud, P. Cutillas, K. Korfi, M. Calaminici, W. Cawthorn, K. Suchacki, A. Nagano, J. G. Gribben, M. Smith, J. D. Cavenagh, H. Oakervee, A. Castleton, D. Taussig, B. Peck, A. Wilczynska, L. McNaughton, D. Bonnet, F. Mardakheh, B. Patel

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

How the bone marrow microenvironment evolves during induction chemotherapy to facilitate acute lymphoblastic leukaemia (ALL) survival remains unclear. Here the authors show that adipocytes emergent during ALL therapy aid the survival of ALL cells thr

Externí odkaz: https://doaj.org/article/5bd437ead45f4de29da3fc82c6989399

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Ablation of Enpp6 Results in Transient Bone Hypomineralization.

Autor: Dillon S; The Roslin Institute and Royal (Dick) School of Veterinary Studies University of Edinburgh Midlothian UK., Suchacki K; Centre for Cardiovascular Science, Queen's Medical Research Institute University of Edinburgh Edinburgh UK., Hsu SN; The Roslin Institute and Royal (Dick) School of Veterinary Studies University of Edinburgh Midlothian UK., Stephen LA; The Roslin Institute and Royal (Dick) School of Veterinary Studies University of Edinburgh Midlothian UK., Wang R; Centre for Cardiovascular Science, Queen's Medical Research Institute University of Edinburgh Edinburgh UK., Cawthorn WP; Centre for Cardiovascular Science, Queen's Medical Research Institute University of Edinburgh Edinburgh UK., Stewart AJ; School of Medicine University of St Andrews St. Andrews UK., Nudelman F; School of Chemistry University of Edinburgh Edinburgh UK., Morton NM; Centre for Cardiovascular Science, Queen's Medical Research Institute University of Edinburgh Edinburgh UK., Farquharson C; The Roslin Institute and Royal (Dick) School of Veterinary Studies University of Edinburgh Midlothian UK.

Publikováno v: JBMR plus [JBMR Plus] 2020 Dec 08; Vol. 5 (2), pp. e10439. Date of Electronic Publication: 2020 Dec 08 (Print Publication: 2021).