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Mutational Analysis of Saccharomyces cerevisiae U4 Small Nuclear RNA Identifies Functionally Important Domains

Autor: Y Xu, Jim Hu, K Schappert, James D. Friesen, Deming Xu

Publikováno v: Molecular and Cellular Biology. 15:1274-1285

U4 small nuclear RNA (snRNA) is essential for pre-mRNA splicing, although its role is not yet clear. On the basis of a model structure (C. Guthrie and B. Patterson, Annu. Rev. Genet. 22:387-419, 1988), the molecule can be thought of as having six dom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d32007cae93421d666ae0824eded49
https://doi.org/10.1128/mcb.15.3.1274

Synergistic Effect between the APOE ε4 Allele with Genetic Variants of GSK3B and MAPT : Differential Profile between Refractory Epilepsy and Alzheimer Disease.

Autor: Toral-Rios, Danira¹ (AUTHOR) rios@wustl.edu, Pichardo-Rojas, Pavel² (AUTHOR) pavel.s.pichardorojas@uth.tmc.edu, Ruiz-Sánchez, Elizabeth³ (AUTHOR) ruizruse@yahoo.com.mx, Rosas-Carrasco, Óscar⁴ (AUTHOR) oscar_rosas_c@hotmail.com, Carvajal-García, Rosa⁵ (AUTHOR) rosacarvajal@sinankay.net, Gálvez-Coutiño, Dey Carol⁶ (AUTHOR) galvezcoutinho@gmail.com, Martínez-Rodríguez, Nancy Lucero⁷ (AUTHOR) amr70@hotmail.com, Rubio-Chávez, Ana Daniela⁸ (AUTHOR) anadanielarubio@gmail.com, Alcántara-Flores, Myr⁹ (AUTHOR) fioremyr@gmail.com, López-Ramírez, Arely⁶ (AUTHOR) arelymlopezr@gmail.com, Martínez-Rosas, Alma Rosa¹⁰ (AUTHOR) appliedneuropsychology@gmail.com, Ruiz-Chow, Ángel Alberto⁹ (AUTHOR) angel.ruiz@innn.edu.mx, Alonso-Vanegas, Mario¹¹ (AUTHOR) alonsovanegasm@gmail.com, Campos-Peña, Victoria⁶ (AUTHOR) vcampos@innn.edu.mx

Publikováno v: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p10228. 20p.

HLA class I, IIIII genes in confirmed late-onset Alzheimer's disease

Autor: Carole Johnston, K. Schappert, Donald Warden, D J Lehmann, Noor Kalsheker, H. Wiebusch, Kevin Morgan, A. D. Smith, S.E. Marshall, Judes Poirier, K.I. Welsh, John H. Xuereb

Publikováno v: Neurobiology of aging. 22(1)

We first examined all the then known alleles (1997) at the HLA-A, B, Bw, C, DRB1, 3, 4 and 5, and DQB1 loci in 55 late-onset (>65y) AD cases and 73 elderly controls from Oxford. We found an association of HLA-B7 with late-onset AD (odds ratio = 3.1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da53a860f0aa33c94ef71db2131f8ae
https://pubmed.ncbi.nlm.nih.gov/11164278

3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency

Autor: G A, Mitchell, M F, Robert, P W, Hruz, S, Wang, G, Fontaine, C E, Behnke, L M, Mende-Mueller, K, Schappert, C, Lee, K M, Gibson, H M, Miziorko

Publikováno v: The Journal of biological chemistry. 268(6)

3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL) catalyzes the final step of ketogenesis, an important pathway of mammalian energy metabolism. HL deficiency is an autosomal recessive inborn error in man leading to episodes of hypoglycemia and coma. U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e184414fb636e5843979f74fce17515f
https://pubmed.ncbi.nlm.nih.gov/8440722