Zobrazeno 1 - 10
of 51
pro vyhledávání: '"K. Salte"'
Autor:
Kathleen M. Smith, Johann E. Gudjonsson, Robert W. Dunstan, Paul W. Harms, Victoria E. Scott, Viktor Todorović, K. Salte, Michael Rosenblum, P. Honore, J. Wetter, Richard E. Burney, Margaret M. Lowe
Publikováno v:
Experimental Dermatology
Since first recognized in 1839, the pathogenesis of acne inversa (AI) has undergone repeated revisions. Although there is agreement that AI involves occlusion of hair follicles with subsequent inflammation and the formation of tracts, the histologic
Autor:
K. Salte, Paul L. Richardson, J.M. Herold, Chaohong Sun, Argiriadi, B. Sielaff, L. Medina, Heath A. McDonald, Sujatha M. Gopalakrishnan, Victoria E. Scott, W. Qiu, J. Wetter, S.J. Kakavas, S.E. Paulsboe, Ramkrishna Sadhukhan, Henning Stöckmann, Rodger F. Henry, J.B. Shotwell, Zhi Su, C.B. Putman, S. McGaraughty, Qi Sun, C. Gerstein, Viktor Todorović, P. Honore
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
IL-36 cytokines are pro-inflammatory members of the IL-1 family that are upregulated in inflammatory disorders. Specifically, IL-36γ is highly expressed in active psoriatic lesions and can drive pro-inflammatory processes in 3D human skin equivalent
Autor:
K. Salte, Yibing Wang, Zhi Su, Steve McGaraughty, Joe Wetter, Laura Leys, Rebecca M. Edelmayer, P. Honore, S.E. Paulsboe, Victoria E. Scott, Stephen B. Gauld, Donna Gauvin, Isaac Weinberg, Marian Namovic
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Psoriasis is an immune-mediated inflammatory skin disease that affects millions worldwide. Studying immune cells involved in psoriasis pathogenesis is essential to identify effective and safe therapeutics for the disease. Using human psoriasis skin,
Autor:
Viktor Todorović, C. Gerstein, Arun Kannan, Li Zhou, S. Huang, S.E. Paulsboe, P. Honore, Ramkrishna Sadhukhan, Victoria E. Scott, Sheeba Mathew, Zhi Su, Leyu Wang, Marian Namovic, Michelle Viner, Rebecca M. Edelmayer, Jane Seagal, Steve McGaraughty, Lisa Rinaldi, Laura Leys, K. Salte, J. Wetter, Amanda Horowitz
Publikováno v:
Experimental Dermatology. 28:113-120
Psoriasis vulgaris (PV) results from activation of IL-23/Th17 immune pathway and is further amplified by cytokines/chemokines from skin cells. Among skin-derived pro-inflammatory cytokines, IL-36 family members are highly upregulated in PV patients a
Autor:
S. Huang, Donna Gauvin, Stephen B. Gauld, S.E. Paulsboe, P. Honore, Zheng Liu, Yibing Wang, Rebecca M. Edelmayer, Lauren Olson, K. Salte, S. McGaraughty, Laura Leys, J. Wetter
Publikováno v:
Journal of Dermatological Science. 92:45-53
Background Animal models of Psoriasis (PsO) are important for our understanding of the pathophysiology of human disease but rarely manifest all features of the disease. In order to facilitate greater understanding of the underlying biology of PsO it
Autor:
Richard McCarthy, Rebecca M. Edelmayer, Maria A. Argiriadi, Didier Bressac, Craig Wallace, Michael E. Kort, Yibing Wang, Laura Leys, Eric C. Breinlinger, J. Wetter, Zhi Su, Jean-Michel Luccarini, P. Honore, K. Salte, Philippe Masson, Christian Goess, Stephen B. Gauld, Kevin P. Cusack, Donna Gauvin, S. Huang, Dominique Potin, Sébastien Jacquet, S. McGaraughty, Kelly E. Desino
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 371(1)
Blockade of interleukin (IL)-23 or IL-17 with biologics is clinically validated as a treatment of psoriasis. However, the clinical impact of targeting other nodes within the IL-23/IL-17 pathway, especially with small molecules, is less defined. We re
Autor:
Xuan Li, J. Wetter, Vivek Kaimal, Zheng Liu, Etienne Saint-Cyr Proulx, Xiaohong Cao, Marika Sarfati, Rebecca M. Edelmayer, Shunya Mashiko, Susan M. Huang, Kathleen M. Smith, Robert Bissonnette, L. Olson, James G. Krueger, K. Salte, Catherine Maari, Yingtao Bi, Jing Wang, Sandra Garcet, Arun Kannan
Publikováno v:
The Journal of investigative dermatology. 140(5)
Many psoriasis patients treated with biologics do not achieve total skin clearance. These patients possess residual plaques despite ongoing biologic treatment. To elucidate mechanisms of plaque persistence despite overall good drug response, we studi
Autor:
Arthur L. Nikkel, Ji Ma, L. Olson, Sujatha M. Gopalakrishnan, Kelly J. Doyle, Vivek C. Abraham, D. L. Widomski, Steve McGaraughty, Brent Putman, Murali Gopalakrishnan, Laura Leys, Chang Z. Zhu, Steve D. Pratt, Zhi Su, Chih-Hung Lee, K. Salte
Publikováno v:
European Journal of Pharmacology. 788:1-11
Adenosine (ADO) is an important regulatory purine nucleoside that accumulates at sites of inflammation and tissue injury including in diseases associated with renal pathology. Endogenous levels of ADO may be increased by inhibiting the ADO-metabolizi
Autor:
Diana L. Donnelly-Roberts, Arthur L. Nikkel, Chang Z. Zhu, Steve McGaraughty, Kelly J. Doyle, Murali Gopalakrishnan, Marian T. Namovic, K. Salte, Lauren Olsen, D. L. Widomski, Zhi Su
Publikováno v:
Journal of pharmacological and toxicological methods. 94(Pt 1)
Introduction The adenine model of kidney disease typically involves dietary delivery of adenine over several weeks. This model can be variable in its disease progression and can result in significant mortality. In the current study, the amount of ade
Publikováno v:
Journal of Investigative Dermatology. 139:S123