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POS0155 WHAT DRIVES RACIAL DISPARITIES IN GOUT IN THE US? – POPULATION-BASED, SEX-SPECIFIC, CASUAL MEDIATION ANALYSIS

Autor: N. Mccormick, L. Lu, C. Yokose, A. Joshi, T. Merriman, K. Saag, Y. Zhang, H. Choi

Publikováno v: Annals of the Rheumatic Diseases. 81:305-306

BackgroundTraditionally viewed as a disease of White men, global frequency and disability burden of female gout are rising disproportionately to male gout.1 Moreover, emerging US cohort data suggest gout and hyperuricemia impart larger burdens on Bla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e4705230a156ebf4b24cb4203fd2344
https://doi.org/10.1136/annrheumdis-2022-eular.2967

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OP0171 A RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED, MULTICENTER, STUDY OF METHOTREXATE COMBINED WITH PEGLOTICASE IN PATIENTS WITH UNCONTROLLED GOUT

Autor: J. Botson, K. Saag, J. Peterson, N. Parikh, S. Ong, D. La, K. Obermeyer, B. Lamoreaux, S. Sainati, S. Grewal, A. Majjhoo, J. Tesser, M. E. Weinblatt

Publikováno v: Annals of the Rheumatic Diseases. 81:112.1-113

BackgroundPatients (pts) with gout refractory to oral urate-lowering therapy (ULT) have few treatment options. Pegloticase (pegylated uricase) lowers serum uric acid (sUA) in these pts,1 but response rates are limited by anti-drug antibodies (ADAs),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d5cb414fc27ee86bcd010f7972c8375
https://doi.org/10.1136/annrheumdis-2022-eular.2949

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POS1160 PROTECT: PEGLOTICASE TREATMENT FOR UNCONTROLLED GOUT IN KIDNEY TRANSPLANTED PATIENTS; RESULTS FROM A PHASE 4 TRIAL

Autor: A. Abdellatif, L. Zhao, K. Cherny, B. Marder, J. Scandling, K. Saag

Publikováno v: Annals of the Rheumatic Diseases. 81:908.2-909

BackgroundA phase 4 trial (NCT04087720) of kidney transplant (KT) recipients on stable immunosuppressants with uncontrolled gout previously reported that pegloticase produced a sustained decrease in serum uric acid (sUA) levels and was associated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfa077a9556ec5806f15390ca71d5c27
https://doi.org/10.1136/annrheumdis-2022-eular.2175

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POS1171 TRIPLE THE RATE OF EMERGENCY ROOM VISITS AND HOSPITALIZATIONS FOR GOUT AMONG US BLACKS VS WHITES – 2019 NATIONWIDE ANALYSIS

Autor: C. Yokose, N. Mccormick, N. Lu, A. Joshi, L. Jackson, M. Kohler, J. Yinh, Y. Zhang, K. Saag, H. Choi

Publikováno v: Annals of the Rheumatic Diseases. 81:913.3-914

BackgroundGout is a highly prevalent inflammatory arthritis with increasing global disease burden in recent years.1,2 Gout prevalence has been reported to be higher among Blacks compared to Whites,3 and that they are less likely to receive allopurino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d921ef4640cc749290059df71358e97
https://doi.org/10.1136/annrheumdis-2022-eular.4189

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POS1147 CHALLENGES IN CONDUCTING PRAGMATIC CARE STRATEGY STUDIES IN OSTEOPOROSIS: PATIENT PERCEPTIONS

Autor: L. Jackson, E. Mcneeley, N. C. Techarukpong, F. Mugeta, K. Aaron, A. Mudano, J. Merchant, K. Warren, J. Foster, K. Saag, M. Danila

Publikováno v: Annals of the Rheumatic Diseases. 81:902.1-902

BackgroundLarge pragmatic osteoporosis studies to improve outcomes are needed. Direct-to-patient studies have highest generalizability but achieving sufficient sample size is difficult; recruitment challenges represent an important consideration give

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db110bde7fb7336ee2c509ec0c648863
https://doi.org/10.1136/annrheumdis-2022-eular.2473

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Early changes in bone turnover and bone mineral density after discontinuation of long-term oral bisphosphonates: a post hoc analysis

Autor: K, Saag, F, Cosman, T, De Villiers, B, Langdahl, B B, Scott, A E, Denker, A, Pong, A C, Santora

Publikováno v: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 32(9)

This post hoc analysis of a randomized, double-blind study of postmenopausal women with osteoporosis found that there were early increases in bone turnover markers and decreases in bone mineral density after discontinuation of long-term alendronate.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f1f20774dbd4f33c1b8c6db45e54e11
https://pubmed.ncbi.nlm.nih.gov/33606045

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