Insufficient Mechanical Loading Downregulates Piezo1 in Chondrocytes and Impairs Fracture Healing Through ApoE-Induced Senescence.

Autor: Jia S; Department of Orthopaedic Surgery, NHC Key Laboratory of Intelligent Orthopaedic Equipment, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China.; Hebei Medical University Clinical Medicine Postdoctoral Station (Hebei Medical University Third Hospital), Shijiazhuang, Hebei, 050051, China., Liu W; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China., Zhang M; Hebei Medical University Clinical Medicine Postdoctoral Station (Hebei Medical University Third Hospital), Shijiazhuang, Hebei, 050051, China.; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang, 050017, China., Wang L; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Hainan Academy of Medical Sciences and School of Basic Medicine, Hainan Medical University, Hainan, 570000, China.; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Ren C; Department of Orthopaedic Surgery, NHC Key Laboratory of Intelligent Orthopaedic Equipment, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China., Feng C; Department of Orthopaedic Surgery, NHC Key Laboratory of Intelligent Orthopaedic Equipment, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China., Zhang T; Department of Orthopaedic Surgery, NHC Key Laboratory of Intelligent Orthopaedic Equipment, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China., Lv H; Department of Orthopaedic Surgery, NHC Key Laboratory of Intelligent Orthopaedic Equipment, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China., Hou Z; Department of Orthopaedic Surgery, NHC Key Laboratory of Intelligent Orthopaedic Equipment, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China., Zou W; Hainan Institute of Regenerative Orthopedics and Sports Medicine, Hainan Academy of Medical Sciences and School of Basic Medicine, Hainan Medical University, Hainan, 570000, China.; Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Zhang Y; Department of Orthopaedic Surgery, NHC Key Laboratory of Intelligent Orthopaedic Equipment, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China., Tong W; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China., Wang J; Department of Orthopaedic Surgery, NHC Key Laboratory of Intelligent Orthopaedic Equipment, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China., Chen W; Department of Orthopaedic Surgery, NHC Key Laboratory of Intelligent Orthopaedic Equipment, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Oct 17, pp. e2400502. Date of Electronic Publication: 2024 Oct 17.

The mRNAs for the three chains of human collagen type XI are widely distributed but not necessarily co-expressed: implications for homotrimeric, heterotrimeric and heterotypic collagen molecules

Autor: Richard Y.C. Kong, John M. Nicholls, K S E Cheah, V C H Lui, Annie N.Y. Cheung

Publikováno v: Biochemical Journal. 311:511-516

In cartilage collagen type XI exists as heterotrimeric molecules composed of alpha 1(XI), alpha 2(XI) and alpha 3(XI) subunits. Messenger RNAs for some of the alpha chains of collagen type XI have also been found in non-chondrogenic tissues but the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c419fa64bfeaaf1e597712cb5bf3e4d
https://doi.org/10.1042/bj3110511

AAV‐mediated Gene Cocktails Enhance Supporting Cell Reprogramming and Hair Cell Regeneration.

Autor: Zhang, Liyan¹ (AUTHOR), Chen, Xin¹ (AUTHOR), Wang, Xinlin¹ (AUTHOR), Zhou, Yinyi¹ (AUTHOR), Fang, Yuan¹ (AUTHOR), Gu, Xingliang¹ (AUTHOR), Zhang, Ziyu¹ (AUTHOR), Sun, Qiuhan¹ (AUTHOR), Li, Nianci¹ (AUTHOR), Xu, Lei^2,3 (AUTHOR) sdphxl@email.sdu.edu.cn, Tan, Fangzhi¹ (AUTHOR) 101013491@seu.edu.cn, Chai, Renjie^1,4,5,6,7 (AUTHOR) renjiec@seu.edu.cn, Qi, Jieyu^1,4,5 (AUTHOR) jieyuqi@seu.edu.cn

Publikováno v: Advanced Science. 8/7/2024, Vol. 11 Issue 29, p1-16. 16p.

Development of Three-Dimensional Culture System for Maintenance of Bovine Nucleus Pulposus Cells

Autor: W. H. Chooi, D. Chan, B. Pui Chan, J. N. Ma, K. S. E. Cheah, H. Y. Li

Publikováno v: Global Spine Journal. 4:s-0034

Introduction Nucleus pulposus (NP) is located at the center of the intervertebral disc (IVD) and rich in collagen type II and proteoglycans. The glycosaminoglycans (GAGs) in the proteoglycans enable the retention of a high amount of water, which is i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7c3429c592b3c123712adb01f5ea58d
https://doi.org/10.1055/s-0034-1376659

Advances of Structural Design and Biomedical Applications of Tobacco Mosaic Virus Coat Protein.

Autor: Zhang, Jialun^1,2 (AUTHOR), He, Haobo^1,3 (AUTHOR), Zeng, Fanmeng^1,3 (AUTHOR), Du, Mingming^1,3 (AUTHOR) mmdu2016@sinano.ac.cn, Huang, Dehua^1,3 (AUTHOR), Chen, Guangcun^1,3 (AUTHOR) gcchen2011@sinano.ac.cn, Wang, Qiangbin^1,3,4 (AUTHOR) qbwang2008@sinano.ac.cn

Publikováno v: Advanced Nanobiomed Research. May2024, Vol. 4 Issue 5, p1-17. 17p.