Zobrazeno 1 - 10
of 52
pro vyhledávání: '"K. Rines"'
Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
Autor:
Amy K. Rines, Hsiang-Chun Chang, Rongxue Wu, Tatsuya Sato, Arineh Khechaduri, Hidemichi Kouzu, Jason Shapiro, Meng Shang, Michael A. Burke, Eltyeb Abdelwahid, Xinghang Jiang, Chunlei Chen, Tenley A. Rawlings, Gary D. Lopaschuk, Paul T. Schumacker, E. Dale Abel, Hossein Ardehali
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The Snf1-related kinase (SNRK) is widely expressed and yet its function is poorly understood. Here the authors show that SNRK regulates mitochondrial coupling via the Trib3-PPARα-UCP3 pathway and that cardiac overexpression of SNRK decreases metabol
Externí odkaz:
https://doaj.org/article/bae6e26f24c34045be0fbe2c38eff574
We estimate the mass accretion rate (MAR) of the 346 clusters of galaxies in the HectoMAP Cluster Survey. The clusters span the redshift range $0.17-0.42$ and the $M_{200}$ mass range $\approx (0.5 - 3.5)\cdot 10^{14} M_\odot$. The MAR estimate is ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734fe3512ef2c47b04fda83a5676427d
https://hdl.handle.net/2318/1890588
https://hdl.handle.net/2318/1890588
Autor:
Amy K. Rines, Hsiang-Chun Chang, Rongxue Wu, Tatsuya Sato, Arineh Khechaduri, Hidemichi Kouzu, Jason Shapiro, Meng Shang, Michael A. Burke, Eltyeb Abdelwahid, Xinghang Jiang, Chunlei Chen, Tenley A. Rawlings, Gary D. Lopaschuk, Paul T. Schumacker, E. Dale Abel, Hossein Ardehali
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8: Article number: 14095 (2017); Published: 24 January 2017; Updated: 30 August 2017. The authors inadvertently omitted Eltyeb Abdelwahid, who contributed to the generation of animal models and their initial evaluation, from the
Externí odkaz:
https://doaj.org/article/a5eea96a56044e2e98ff7084497fa6d3
Publikováno v:
Annals of the New York Academy of Sciences. 1411:21-35
The coordinated regulation between cellular glucose uptake and endogenous glucose production is indispensable for the maintenance of constant blood glucose concentrations. The liver contributes significantly to this process by altering the levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed6d73b971cec356501e6f31144d769a
https://doi.org/10.1111/nyas.13435
https://doi.org/10.1111/nyas.13435
Publikováno v:
Nature Reviews Drug Discovery. 15:786-804
Type 2 diabetes mellitus is characterized by the dysregulation of glucose homeostasis, resulting in hyperglycaemia. Although current diabetes treatments have exhibited some success in lowering blood glucose levels, their effect is not always sustaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7d6e2554d5e4072720a389b638aff82
https://doi.org/10.1038/nrd.2016.151
https://doi.org/10.1038/nrd.2016.151
Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
Autor:
Hossein Ardehali, Amy K. Rines, Paul T. Schumacker, Arineh Khechaduri, Chunlei Chen, Tenley A. Rawlings, Hidemichi Kouzu, Michael A. Burke, Xinghang Jiang, Tatsuya Sato, E. Dale Abel, Rongxue Wu, Jason S. Shapiro, Meng Shang, Hsiang-Chun Chang, Gary D. Lopaschuk
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Ischaemic heart disease limits oxygen and metabolic substrate availability to the heart, resulting in tissue death. Here, we demonstrate that the AMP-activated protein kinase (AMPK)-related protein Snf1-related kinase (SNRK) decreases cardiac metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be586dd9a16cb689564582d4cda761a9
https://pubmed.ncbi.nlm.nih.gov/28853433
https://pubmed.ncbi.nlm.nih.gov/28853433
Autor:
Francisco Verdeguer, Mitsuhisa Tabata, Kfir Sharabi, Amy K. Rines, Pere Puigserver, Christian Trautwein, Chi Luo, Maximilian Hatting, Jessica A. Hall
Publikováno v:
Cell metabolism. 25(2)
A promising approach to treating obesity is to increase diet-induced thermogenesis in brown adipose tissue (BAT), but the regulation of this process remains unclear. Here we find that CDC-like kinase 2 (CLK2) is expressed in BAT and upregulated upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5decddee6725b9653e03d2d1cedf10f6
https://pubmed.ncbi.nlm.nih.gov/28089567
https://pubmed.ncbi.nlm.nih.gov/28089567
Publikováno v:
The FASEB Journal. 26:4685-4695
Sucrose nonfermenting 1 (Snf1)-related kinase (SNRK) is a serine/threonine kinase with sequence similarity to AMP-activated protein kinase (AMPK); however, its function is not well characterized. We conducted a gene array to determine which genes are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003004c59f23795bdbfbee3bd8a0c989
https://doi.org/10.1096/fj.12-212282
https://doi.org/10.1096/fj.12-212282
Autor:
J. Andrew Wassertsrom, Sakie Nakamura, Hossein Ardehali, Tejaswitha J Naik, Robert S. Decker, Amy K. Rines
Publikováno v:
Translational Research. 155:27-34
alpha- and beta-Adrenergic receptor agonists induce an inotropic response in the adult heart by promoting the phosphorylation of several regulatory proteins, including myosin-binding protein C (MyBP-C), cardiac troponin I (cTnI), and phospholamban (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de74b858eb43ca0de154d7e0c0a17d45
https://doi.org/10.1016/j.trsl.2009.09.007
https://doi.org/10.1016/j.trsl.2009.09.007
Publikováno v:
Molecular aspects of medicine. 46
Maintaining blood glucose concentration within a relatively narrow range through periods of fasting or excess nutrient availability is essential to the survival of the organism. This is achieved through an intricate balance between glucose uptake and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e229f9c46dc096b824270ae30203db7
https://pubmed.ncbi.nlm.nih.gov/26549348
https://pubmed.ncbi.nlm.nih.gov/26549348