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Akademický článek

The Sensory and Cognitive Ecology of Nectar Robbing

Autor: Sarah K. Richman, Jessica L. Barker, Minjung Baek, Daniel R. Papaj, Rebecca E. Irwin, Judith L. Bronstein

Publikováno v: Frontiers in Ecology and Evolution, Vol 9 (2021)

Animals foraging from flowers must assess their environment and make critical decisions about which patches, plants, and flowers to exploit to obtain limiting resources. The cognitive ecology of plant-pollinator interactions explores not only the com

Externí odkaz: https://doaj.org/article/a315e3c4467241f0ab33c6d7966d825f

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Akademický článek

Do honeybees act as pollen thieves or pollinators of Datura wrightii?

Autor: Andrew C. McCall, Sarah K. Richman, Eric Thomson, Monica Edgerton, Skyler Jordan, Judith Bronstein

Publikováno v: Journal of Pollination Ecology, Vol 24, Pp 164-171 (2018)

Datura wrightii (Solanaceae), a common shrub in the southwestern United States, bears massive, white, night-blooming flowers that attract and reward hawkmoth pollinators. However, Apis mellifera (honeybee) foragers are often observed on its flowers,

Externí odkaz: https://doaj.org/article/9c353abc815e45cf951ec2620a860be0

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Akademický článek

AAV8 Gene Therapy for Crigler-Najjar Syndrome in Macaques Elicited Transgene T Cell Responses That Are Resident to the Liver

Autor: Jenny A. Greig, Roberto Calcedo, Leticia Kuri-Cervantes, Jayme M.L. Nordin, Jessica Albrecht, Erin Bote, Tamara Goode, Edward A. Chroscinski, Peter Bell, Laura K. Richman, Michael R. Betts, James M. Wilson

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 11, Iss , Pp 191-201 (2018)

Systemic delivery of adeno-associated viral (AAV) vectors has been evaluated for the treatment of several liver diseases, including homozygous familial hypercholesterolemia, ornithine transcarbamylase deficiency, and hemophilia. Here, we evaluated th

Externí odkaz: https://doaj.org/article/01118e8f567e49fb8ab1d3079ca6e907

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Akademický článek

Toxicology Study of Intra-Cisterna Magna Adeno-Associated Virus 9 Expressing Human Alpha-L-Iduronidase in Rhesus Macaques

Autor: Juliette Hordeaux, Christian Hinderer, Tamara Goode, Nathan Katz, Elizabeth L. Buza, Peter Bell, Roberto Calcedo, Laura K. Richman, James M. Wilson

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 79-88 (2018)

Mucopolysaccharidosis type I is a recessive genetic disease caused by deficiency of the lysosomal enzyme α-L-iduronidase, which leads to a neurodegenerative and systemic disease called Hurler syndrome in its most severe form. Several clinical trials

Externí odkaz: https://doaj.org/article/1f37efe1f3c9466eaf96059d5c8d3fc8

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Akademický článek

Toxicology Study of Intra-Cisterna Magna Adeno-Associated Virus 9 Expressing Iduronate-2-Sulfatase in Rhesus Macaques

Autor: Juliette Hordeaux, Christian Hinderer, Tamara Goode, Elizabeth L. Buza, Peter Bell, Roberto Calcedo, Laura K. Richman, James M. Wilson

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 68-78 (2018)

Hunter syndrome is an X-linked recessive disease caused by deficiency of the lysosomal enzyme iduronate-2-sulfatase. The severe form of this progressive, systemic, and neurodegenerative disease results in loss of cognitive skills and early death. Sev

Externí odkaz: https://doaj.org/article/5a204333500b4ac4af8e689cf632c042

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Akademický článek

Determining the Minimally Effective Dose of a Clinical Candidate AAV Vector in a Mouse Model of Crigler-Najjar Syndrome

Autor: Jenny A. Greig, Jayme M.L. Nordin, Christine Draper, Deirdre McMenamin, Edward A. Chroscinski, Peter Bell, John T. Gray, Laura K. Richman, James M. Wilson

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 237-244 (2018)

Liver metabolism disorders are attractive targets for gene therapy, because low vector doses can reverse the buildup of toxic metabolites in the blood. Crigler-Najjar syndrome is an inherited disorder of bilirubin metabolism that is caused by the abs

Externí odkaz: https://doaj.org/article/0cdfa4f8c1e84e47b68f369400bd39cb

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