Zobrazeno 1 - 10
of 230
pro vyhledávání: '"K. Ravi Acharya"'
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 299 (2024)
α-Methylacyl-CoA racemase in M. tuberculosis (MCR) has an essential role in fatty acid metabolism and cholesterol utilization, contributing to the bacterium’s survival and persistence. Understanding the enzymatic activity and structural features o
Externí odkaz:
https://doaj.org/article/d66d65e2902d46ff934b3d658be25e44
Autor:
Amelia Barclay, K. Ravi Acharya
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1407 (2023)
Plastic pollution has emerged as a significant environmental concern in recent years and has prompted the exploration of innovative biotechnological solutions to mitigate plastic’s negative impact. The discovery of enzymes capable of degrading spec
Externí odkaz:
https://doaj.org/article/b40af6b119214749935241449e449d35
Autor:
Kyle S. Gregory, Peter-Rory Hall, Jude Prince Onuh, Otsile O. Mojanaga, Sai Man Liu, K. Ravi Acharya
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12721 (2023)
Clostridium botulinum neurotoxins (BoNTs) are the most potent toxins known, causing the deadly disease botulism. They function through Zn2+-dependent endopeptidase cleavage of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein recept
Externí odkaz:
https://doaj.org/article/30fdc7641b4b4f348cd16918aed2717a
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1132 (2023)
A novel protein, PID-5, has been shown to be a requirement for germline immortality and has recently been implicated in RNA-induced epigenetic silencing in the Caenorhabditis elegans embryo. Importantly, it has been shown to contain both an eTudor an
Externí odkaz:
https://doaj.org/article/83983e4888394cac85b05a12fc560929
Publikováno v:
FEBS Open Bio, Vol 10, Iss 8, Pp 1474-1481 (2020)
Clostridium botulinum neurotoxins (BoNTs) cause flaccid paralysis through inhibition of acetylcholine release from motor neurons; however, at tiny doses, this property is exploited for use as a therapeutic. Each member of the BoNT family of proteins
Externí odkaz:
https://doaj.org/article/5de009e49ba743fe96fe659728df4766
Publikováno v:
FEBS Open Bio, Vol 10, Iss 3, Pp 298-305 (2020)
Botulinum neurotoxins (BoNTs) are one of the most toxic proteins known to humans. Their molecular structure is comprised of three essential domains—a cell binding domain (HC), translocation domain and catalytic domain (light chain) . The HC domain
Externí odkaz:
https://doaj.org/article/1cdef2f317864057b51401ece16369a1
Autor:
Kyle S. Gregory, K. Ravi Acharya
Publikováno v:
Toxins, Vol 15, Iss 2, p 92 (2023)
Botulinum neurotoxins (BoNTs) cause flaccid neuromuscular paralysis by cleaving one of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex proteins. BoNTs display high affinity and specificity for neuromuscular j
Externí odkaz:
https://doaj.org/article/15e3ead70a664f048026b993ca13320f
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9620 (2022)
Clostridium botulinum neurotoxin A (BoNT/A) targets the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, by cleaving synaptosomal-associated protein of 25 kDa size (SNAP-25). Cleavage of SNAP-25 results in flacci
Externí odkaz:
https://doaj.org/article/169a979463c746abb7d2e198e97eb74c
Publikováno v:
Toxins, Vol 14, Iss 5, p 356 (2022)
Botulinum neurotoxins (BoNT) are a group of clostridial toxins that cause the potentially fatal neuroparalytic disease botulism. Although highly toxic, BoNTs are utilized as therapeutics to treat a range of neuromuscular conditions. Several serotypes
Externí odkaz:
https://doaj.org/article/74136a3a6d9442c288f712c255acd27b
Publikováno v:
Toxins, Vol 14, Iss 2, p 129 (2022)
Botulinum neurotoxins (BoNT) cause the potentially fatal neuroparalytic disease botulism that arises due to proteolysis of a SNARE protein. Each BoNT is comprised of three domains: a cell binding domain (HC), a translocation domain (HN), and a cataly
Externí odkaz:
https://doaj.org/article/9669e8f625fc40b3a6061f10f9e9c634