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CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment?

Autor: Jan Hendrik Niess, K Radulovic

Publikováno v: Journal of Immunology Research, Vol 2015 (2015)
Journal of Immunology Research

CD69 has been identified as an early activation marker of lymphocytes. However, recent work has indicated that CD69 plays an essential role for the regulation of inflammatory processes. Particularly, CD69 is highly expressed by lymphocytes at mucosal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0792db0843c22db30d5391fe170e0c97
https://doi.org/10.1155/2015/497056

CX3CR1+ macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium

Autor: JH Niess, K Radulovic, N Garbi, Christian U. Riedel, V Rossini, C Manta, Esther Heupel

Publikováno v: Mucosal Immunology

Innate immune cells, such as intestinal epithelial cells, dendritic cells (DCs), macrophages, granulocytes, and innate lymphoid cells provide a first line of defence to enteric pathogens. To study the role of CX(3)CR1(+) DCs and macrophages in host d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcc4635a8dd04d35571b6d14cd88edd
https://doi.org/10.1038/mi.2012.61

A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation

Autor: Bernhard Ryffel, Lionel F. Poulin, Myriam Delacre, Ateequr Rehman, Philip Rosenstiel, A Delanoye-Crespin, J Chatagnon, Nadine Waldschmitt, Mathias Chamaillard, Juan L. Iovanna, S Normand, K Radulovic

Publikováno v: Mucosal immunology. 11(3)

Flavones represent a class of polyphenols that are found in many plant-derived food sources. Herein, we provide evidence that the anti-inflammatory and antiproliferative effect of the flavone apigenin relies on the regulation of the gut microbiota by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8f1c609ad88fc4221782ee2e462adc
https://pubmed.ncbi.nlm.nih.gov/29139477

Gastro-intestinal tract: The leading role of mucosal immunity

Autor: Jan Hendrik Niess, Anna Steinert, K Radulovic

Publikováno v: Steinert, Anna; Radulovic, Katarina; Niess, Jan Hendrik (2016). Gastro-intestinal tract: The leading role of mucosal immunity. Swiss medical weekly, 146, w14293. EMH Schweizerischer Ärzteverlag 10.4414/smw.2016.14293
Swiss Med Wkly

An understanding of mucosal immunity is essential for the comprehension of intestinal diseases that are often caused by a complex interplay between host factors, environmental influences and the intestinal microbiota. Not only improvements in endosco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa6ccb880c2fa5bb9221d5e69a71f46
https://boris.unibe.ch/104837/1/smw.2016.14293.pdf