Zobrazeno 1 - 10
of 58
pro vyhledávání: '"K. R. Scott"'
Autor:
Le T. Duong, Gouxin Wu, Christopher T. Winkelmann, Michael A. Gentile, Pete Szczerba, Randy Crawford, K. R. Scott
Publikováno v:
Bone. 93
Odanacatib (ODN) a selective and reversible cathepsin K inhibitor, inhibits bone resorption, increases bone mass and reduces fracture risk in women with osteoporosis. A 16-month (~7-remodeling cycles) study was carried out in treatment mode to assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09dc6484d716292d0c7edc9ffa6aca0
https://pubmed.ncbi.nlm.nih.gov/27639811
https://pubmed.ncbi.nlm.nih.gov/27639811
Autor:
Brenda L Pennypacker, Ya Zhuo, Susan Y. Smith, K. R. Scott, T. Cusick, Rana Samadfam, Le T. Duong, Charles Chen, Maureen Pickarski
Publikováno v:
Bone. 88
The objectives here were to evaluate the effects of odanacatib (ODN) at doses exceeding the clinical exposure on biomechanical properties of lumbar vertebrae (LV), hip and central femur (CF), and compare ODN to alendronate (ALN) on bone remodeling/mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae0d0149c1a371a9f3181ed7b88ef8c
https://pubmed.ncbi.nlm.nih.gov/27126999
https://pubmed.ncbi.nlm.nih.gov/27126999
Autor:
Le T. Duong, Maureen Pickarski, Susan Y. Smith, P. Masarachia, Donald B. Kimmel, G Wesolowski, Brenda L Pennypacker, Boyd B. Scott, Rani Samadfam, Jason E. Goetzmann, K. R. Scott
Publikováno v:
Journal of Bone and Mineral Research. 27:509-523
Odanacatib (ODN) is a selective and reversible inhibitor of cathepsin K (CatK) currently being developed as a once-weekly treatment for osteoporosis. In this study, we evaluated the effects of ODN on bone turnover, bone mineral density (BMD), and bon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dad717bac3c9aecbd1dac2fdae21c49
https://doi.org/10.1002/jbmr.1475
https://doi.org/10.1002/jbmr.1475
Autor:
Noha N. Salama, Natalie D. Eddington, Ivan O. Edafiogho, Kethireddy V.V. Ananthalakshmi, Samuel B. Kombian, Patrice L. Jackson, K. R. Scott, Mariano S. Alexander, Tiffany L. Wilson, Clive D. Hanson
Publikováno v:
Journal of Pharmaceutical Sciences. 96:2509-2531
Enaminones, enamines of beta-dicarbonyl compounds, have been known for many years. Their early use has been relegated to serving as synthetic intermediates in organic synthesis and of late, in pharmaceutical development. Recently, the therapeutic pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23838db88d4d3899c10282d6f25ffe1d
https://doi.org/10.1002/jps.20967
https://doi.org/10.1002/jps.20967
Publikováno v:
Medicinal Chemistry. 1:371-381
The enaminones represent potentially useful agents for the clinical treatment in generalized tonic-clonic seizures (Epilepsia, 1993, 34(6), 1141-1145, Biopharm. Drug Disp. 2003, 397-407). A regression analysis was performed to provide a quantitative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f4955d131b688dd571751827b262dec
https://doi.org/10.2174/1573406054368710
https://doi.org/10.2174/1573406054368710
Publikováno v:
Journal of Combinatorial Chemistry. 6:950-954
An improved method for the synthesis of benzamides from 3-amino-2-cyclohexenones is presented. Using sodium hydride, a base-catalyzed N-benzoylation provided significantly higher yields (71-79%) for the reported compounds. This novel protocol was app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cc29020bdea58ef02e659d1c97debc
https://doi.org/10.1021/cc0498837
https://doi.org/10.1021/cc0498837
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 24:565-577
A simple high performance liquid chromatography (HPLC) method has been developed for the stability study of an anticonvulsant enaminone (E139). Using a Chiral HSA column and a mobile phase of n-octanoic acid (5 mM) and isopropyl alcohol and disodium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::211244d458aceb927a00450ecf0c7f63
https://doi.org/10.1081/jlc-100103394
https://doi.org/10.1081/jlc-100103394
Autor:
Lyndia D. Sims, Jacqueline A. Moore, Kymberle R. Kolen, Ivan O. Edafiogho, Mariano S. Alexander, Gary O. Rankin, K. R. Scott, Vida A. Farrar, Ahn D. Tonnu, James P. Stables
Publikováno v:
Journal of Medicinal Chemistry. 38:4033-4043
In a continuing evaluation of the aniline-substituted enaminones, the synthesis of additional para-substituted analogs has been made in an attempt to further quantify the electronic (sigma) and lipophilic (pi) requirements for anticonvulsant activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::915e04dfd664c3dcb26b9caa63ee7221
https://doi.org/10.1021/jm00020a019
https://doi.org/10.1021/jm00020a019
Autor:
John E. Fisher, Helmut Glantschnig, Brenda L Pennypacker, K. R. Scott, Ronald B. Langdon, Tara E. Cusick, B. B. Zhang, Donald B. Kimmel, J. Mu, X. Shen, Z. Li
Publikováno v:
Diabetes, obesitymetabolism. 15(10)
Antihyperglycaemic therapy on bone was evaluated in the ovariectomized (OVX), non-diabetic adult rat. Animals were treated daily for 12 weeks with various doses of sitagliptin, pioglitazone, rosiglitazone, combinations of sitagliptin with pioglitazon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2714c99345b9f0b7b6db5741004673b7
https://pubmed.ncbi.nlm.nih.gov/23551951
https://pubmed.ncbi.nlm.nih.gov/23551951
Publikováno v:
Current Medicinal Chemistry. 1:159-175
Enaminones, enamines of B-dicarbonyl compounds have been known for many years. Their main therapeutic utility was as prodrugs for various amines, stabilizing these active compounds principally in basic media. Our laboratory discovered a series of ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d666df8f6842c69150d0dd7162ad9d48
https://doi.org/10.2174/092986730102220214154054
https://doi.org/10.2174/092986730102220214154054