Výsledky vyhledávání - "K. R. Peterson"

Production of transgenic mice with yeast artificial chromosomes

Autor: K R, Peterson, C H, Clegg, Q, Li, G, Stamatoyannopoulos

Publikováno v: Trends in Genetics. 13:61-66

Techniques are now available that allow the transfer of intact yeast artificial chromosome (YAC) DNA into transgenic mice. Coupled with the ability to perform mutagenesis on YAC sequences by homologous recombination in yeast, they enable the analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9a96d625802315327c46b377f0c2ea
https://doi.org/10.1016/s0168-9525(97)01003-2

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Role of gene order in developmental control of human gamma- and beta-globin gene expression

Autor: K R Peterson, G Stamatoyannopoulos

Publikováno v: Molecular and Cellular Biology. 13:4836-4843

To determine the effect of gene order on globin gene developmental regulation, we produced transgenic mice containing two tandemly arranged gamma- or beta-globin or gamma beta- and beta gamma-globin genes linked to a 2.5-kb cassette containing sequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c583f7a287cf47a90a082939ed6d017
https://doi.org/10.1128/mcb.13.8.4836

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Meteorological Modeling of Arrival and Deposition of Fallout at Intermediate Distances Downwind of the Nevada Test Site

Autor: K R Peterson, R T Cederwall

Publikováno v: Health Physics. 59:593-601

A three-dimensional atmospheric transport and diffusion model is used to calculate the arrival and deposition of fallout from 13 selected nuclear tests at the Nevada Test Site (NTS) in the 1950s. Results are used to extend NTS fallout patterns to int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34702dbebedf8ae3be6b0710e88c1eae
https://doi.org/10.1097/00004032-199011000-00010

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The 5'HS4 core element of the human beta-globin locus control region is required for high-level globin gene expression in definitive but not in primitive erythropoiesis

Autor: P A, Navas, K R, Peterson, Q, Li, M, McArthur, G, Stamatoyannopoulos

Publikováno v: Journal of molecular biology. 312(1)

To assess the contribution of DNase I-hypersensitive site 4 (HS4) of the beta-globin locus control region (LCR) to overall LCR function we deleted a 280 bp fragment encompassing the core element of 5'HS4 from a 248 kb beta-globin locus yeast artifici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::245dc44c0420a4591501f95d2cdc3669
https://pubmed.ncbi.nlm.nih.gov/11545582

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Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos

Autor: A C, Perkins, K R, Peterson, G, Stamatoyannopoulos, H E, Witkowska, S H, Orkin

Publikováno v: Blood. 95(5)

Mice lacking the erythroid Kruppel-like factor (EKLF) die in utero at embryonic day 15 (E15) from severe anemia. EKLF(-/-) embryos display a marked deficit in beta-globin gene expression. To test whether beta-globin deficiency was solely responsible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfc0e754eda23a3ba2a4699646a7dd6f
https://pubmed.ncbi.nlm.nih.gov/10688844

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Hemopoietic lineage commitment decisions: in vivo evidence from a transgenic mouse model harboring micro LCR-betapro-LacZ as a transgene

Autor: T, Papayannopoulou, G V, Priestley, A, Rohde, K R, Peterson, B, Nakamoto

Publikováno v: Blood. 95(4)

A substantial body of published data suggests activation of lineage-specific genes in multipotential hemopoietic cells before their unilineage commitment. Because the behavior and plasticity of cells isolated in vitro away from microenvironmental con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4dbc16d76f9ad123e423f167bf0eb171
https://pubmed.ncbi.nlm.nih.gov/10666200

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Correct function of the locus control region may require passage through a nonerythroid cellular environment

Autor: G, Vassilopoulos, P A, Navas, E, Skarpidi, K R, Peterson, C H, Lowrey, T, Papayannopoulou, G, Stamatoyannopoulos

Publikováno v: Blood. 93(2)

The function of the beta-globin locus control region (LCR) has been studied both in cell lines and in transgenic mice. We have previously shown that when a 248-kb beta-locus YAC was first microinjected into L-cells and then transferred into MEL cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fd71c556ca08cdb1b6e84347393c853d
https://pubmed.ncbi.nlm.nih.gov/9885233

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Developmental control of epsilon- and gamma-globin genes

Autor: Q, Li, K R, Peterson, G, Stamatoyannopoulos

Publikováno v: Annals of the New York Academy of Sciences. 850

In the last few years there have been considerable advances in the understanding of the molecular control of globin genes during development. Several insights have been obtained with studies using transgenic mice. The 5' to 3' order of the genes in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4e21912ab36a9b72a175fccf3c504870
https://pubmed.ncbi.nlm.nih.gov/9668523

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