Výsledky vyhledávání - "K. R. Gustafson"

A nonpromoting phorbol from the Samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1

Autor: K R, Gustafson, J H, Cardellina, J B, McMahon, R J, Gulakowski, J, Ishitoya, Z, Szallasi, N E, Lewin, P M, Blumberg, O S, Weislow, J A, Beutler

Publikováno v: Journal of Medicinal Chemistry. 35:1978-1986

Extracts of Homalanthus nutans, a plant used in Samoan herbal medicine, exhibited potent activity in an in vitro, tetrazolium-based assay which detects the inhibition of the cytopathic effects of human immunodeficiency virus (HIV-1). The active const

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69edc69704541da34fad43f64b8d815
https://doi.org/10.1021/jm00089a006

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New cytotoxic N-methylated beta-carboline alkaloids from the marine ascidian Eudistoma gilboverde

Autor: M A, Rashid, K R, Gustafson, M R, Boyd

Publikováno v: Journal of natural products. 64(11)

Bioassay-guided fractionation of an extract of the marine ascidian Eudistoma gilboverde provided three new beta-carboline alkaloids identified as 2-methyleudistomin D (1), 2-methyleudistomin J (2), and 14-methyleudistomidin C (3). Six known metabolit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf92ceb1c017093b17a1fc5baed3f03f
https://pubmed.ncbi.nlm.nih.gov/11720532

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Absolute stereochemistry and anti-HIV activity of minquartynoic acid, a polyacetylene from Ochanostachys amentacea

Autor: M A, Rashid, K R, Gustafson, J H, Cardellina, M R, Boyd

Publikováno v: Natural product letters. 15(1)

Anti-HIV bioassay-guided fractionation of an organic extract of Ochanostachys amentacea provided an HIV-inhibitory polyacetylenic acid. The identity of this compound was established as (-)-17-hydroxy-9,11,13,15-octadecatetraynoic acid (1), also known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c4895fb8580671feae218865c5cda98f
https://pubmed.ncbi.nlm.nih.gov/11547419

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Haligramides A and B, two new cytotoxic hexapeptides from the marine sponge Haliclona nigra

Autor: M A, Rashid, K R, Gustafson, J L, Boswell, M R, Boyd

Publikováno v: Journal of natural products. 63(7)

Bioassay-guided fractionation of a cytotoxic aqueous extract of the sponge Haliclona nigra provided two new cyclic hexapeptides, haligramides A (1) and B (2), in addition to the known peptide, waiakeamide (3). The structures of peptides 1 and 2 were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4176389a7d4c9bf33c7c7ef4ed03a3b3
https://pubmed.ncbi.nlm.nih.gov/10924173

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Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity

Autor: N L, Daly, A, Koltay, K R, Gustafson, M R, Boyd, J R, Casas-Finet, D J, Craik

Publikováno v: Journal of molecular biology. 285(1)

The three-dimensional solution structure of circulin A, a 30 residue polypeptide from the African plant Chassalia parvifolia, has been determined using two-dimensional 1H-NMR spectroscopy. Circulin A was originally identified based upon its inhibitio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12e8bfe90fdf68a41987e5745e5e86e4
https://pubmed.ncbi.nlm.nih.gov/9878410

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Antireplicative and anticytopathic activities of prostratin, a non-tumor-promoting phorbol ester, against human immunodeficiency virus (HIV)

Autor: R J, Gulakowski, J B, McMahon, R W, Buckheit, K R, Gustafson, M R, Boyd

Publikováno v: Antiviral research. 33(2)

Prostratin, a non-tumor-promoting phorbol ester, inhibited human immunodeficiency virus (HIV)-induced cell killing and viral replication in a variety of acutely-infected cell systems. The potency and degree of cytoprotection was dependent on both vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbca780ab6efbafd60f4d09601d211ec
https://pubmed.ncbi.nlm.nih.gov/9021050

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