Zobrazeno 1 - 10
of 209
pro vyhledávání: '"K. Peter R. Nilsson"'
Autor:
Theodore J. Zwang, Eric del Sastre, Nina Wolf, Nancy Ruiz-Uribe, Benjamin Woost, Zachary Hoglund, Zhanyun Fan, Joshua Bailey, Lois Nfor, Luc Buée, K. Peter R. Nilsson, Bradley T. Hyman, Rachel E. Bennett
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114574- (2024)
Summary: A prevailing hypothesis is that neurofibrillary tangles play a causal role in driving cognitive decline in Alzheimer’s disease (AD) because tangles correlate anatomically with areas that undergo neuronal loss. We used two-photon longitudin
Externí odkaz:
https://doaj.org/article/10cc1819ed864e588cd728901f3c62be
Autor:
Maria Calvo-Rodriguez, Elizabeth K. Kharitonova, Austin C. Snyder, Steven S. Hou, Maria Virtudes Sanchez-Mico, Sudeshna Das, Zhanyun Fan, Hamid Shirani, K. Peter R. Nilsson, Alberto Serrano-Pozo, Brian J. Bacskai
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Background Reactive oxidative stress is a critical player in the amyloid beta (Aβ) toxicity that contributes to neurodegeneration in Alzheimer’s disease (AD). Damaged mitochondria are one of the main sources of reactive oxygen species and
Externí odkaz:
https://doaj.org/article/831a14a43be94b0caad5a381475bab71
Autor:
Greta Elovsson, Therése Klingstedt, Mikaela Brown, K. Peter R. Nilsson, Ann-Christin Brorsson
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2105 (2024)
Amyloid-β (Aβ) proteotoxicity is associated with Alzheimer’s disease (AD) and is caused by protein aggregation, resulting in neuronal damage in the brain. In the search for novel treatments, Drosophila melanogaster has been extensively used to sc
Externí odkaz:
https://doaj.org/article/4b419ecd203548eeb2f61f4b1a690016
Autor:
Malin Wennström, Shorena Janelidze, K. Peter R. Nilsson, The Netherlands Brain Bank, Geidy E. Serrano, Thomas G. Beach, Jeffrey L. Dage, Oskar Hansson
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-12 (2022)
Abstract Recent studies highlight phosphorylated tau (p-tau) at threonine tau 217 (p-tau217) as a new promising plasma biomarker for pathological changes implicated in Alzheimer’s disease (AD), but the specific brain pathological events related to
Externí odkaz:
https://doaj.org/article/3e4b283386d94852a888c6c906dc00ef
Autor:
Alejandro Ruiz-Riquelme, Alison Mao, Marim M. Barghash, Heather H. C. Lau, Erica Stuart, Gabor G. Kovacs, K. Peter R. Nilsson, Paul E. Fraser, Gerold Schmitt-Ulms, Joel C. Watts
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from the brains of Alzheimer’s disease (AD) patients or transgenic AD mouse models seed cerebral Aβ deposition in a prion-like fashion. Within the br
Externí odkaz:
https://doaj.org/article/311ee78e40194926b8b50a33d61a9ceb
Autor:
Mie Kristine Just, Hjalte Gram, Vasileios Theologidis, Poul Henning Jensen, K. Peter R. Nilsson, Mikael Lindgren, Karoline Knudsen, Per Borghammer, Nathalie Van Den Berge
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Pathogenic alpha-synuclein (asyn) aggregates are a defining feature of neurodegenerative synucleinopathies, which include Parkinson's disease, Lewy body dementia, pure autonomic failure and multiple system atrophy. Early accurate differentiation betw
Externí odkaz:
https://doaj.org/article/74319bc61f6042bd84cb7d187a9d2369
Autor:
Juan F. Reyes, Sara Ekmark-Léwen, Marina Perdiki, Therése Klingstedt, Alana Hoffmann, Emilia Wiechec, Per Nilsson, K. Peter R. Nilsson, Irina Alafuzoff, Martin Ingelsson, Martin Hallbeck
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-20 (2021)
Abstract Alpha-synuclein (α-syn) aggregation is the hallmark pathological lesion in brains of patients with Parkinson’s disease (PD) and related neurological disorders characterized as synucleinopathies. Accumulating evidence now indicates that α
Externí odkaz:
https://doaj.org/article/d3b37dfdd451474997f2e1e5c9a5e227
Autor:
Gaye Tanriöver, Mehtap Bacioglu, Manuel Schweighauser, Jasmin Mahler, Bettina M. Wegenast-Braun, Angelos Skodras, Ulrike Obermüller, Melanie Barth, Deborah Kronenberg-Versteeg, K. Peter R. Nilsson, Derya R. Shimshek, Philipp J. Kahle, Yvonne S. Eisele, Mathias Jucker
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Abstract Alpha-synucleinopathies are a group of progressive neurodegenerative disorders, characterized by intracellular deposits of aggregated α-synuclein (αS). The clinical heterogeneity of these diseases is thought to be attributed to conformers
Externí odkaz:
https://doaj.org/article/d21f1979370c47cc9fcbb8419a787497
Autor:
Therése Klingstedt, Bernardino Ghetti, Janice L. Holton, Helen Ling, K. Peter R. Nilsson, Michel Goedert
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract Synucleinopathies [Parkinson’s disease with or without dementia, dementia with Lewy bodies and multiple system atrophy] are neurodegenerative diseases that are defined by the presence of filamentous α-synuclein inclusions. We investigated
Externí odkaz:
https://doaj.org/article/8dad256167b248d884bc6cb889998d77
Autor:
Maria Calvo-Rodriguez, Steven S. Hou, Austin C. Snyder, Simon Dujardin, Hamid Shirani, K. Peter R. Nilsson, Brian J. Bacskai
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-10 (2019)
Summary The detection of amyloid beta deposits and neurofibrillary tangles, both hallmarks of Alzheimer’s disease (AD), is key to understanding the mechanisms underlying these pathologies. Luminescent conjugated oligothiophenes (LCOs) enable fluore
Externí odkaz:
https://doaj.org/article/bb1cc6f4dac34bfd84a8973255afbcf6