Zobrazeno 1 - 10
of 17
pro vyhledávání: '"K. P. Willey"'
Autor:
K. P. Willey
Publikováno v:
Human Reproduction Update. 5:330-355
The crescendo of events leading first to ovulation and subsequently to birth is orchestrated by a broad repertoire of hormones. The major hormones of the ovulatory cycle are representatives of four hormone classes: neurotransmitters, releasing factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f772a40a987c0633f081777d99033dfa
https://doi.org/10.1093/humupd/5.4.330
https://doi.org/10.1093/humupd/5.4.330
Publikováno v:
Journal of Clinical Laboratory Analysis. 10:193-204
The extracellular domain of the TSH receptor (TSHR-561, amino acids #78-389) was expressed as a hexa-histidine fusion protein in bacteria. The recombinant protein was purified to homogeneity and used to immunize porcine and ovine species. High titre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f6aba0c14b75553775bfc0ec44ccb4
https://doi.org/10.1002/(sici)1098-2825(1996)10:4<193::aid-jcla4>3.0.co
https://doi.org/10.1002/(sici)1098-2825(1996)10:4<193::aid-jcla4>3.0.co
Publikováno v:
Journal of Reproductive Immunology. 24:45-63
In order to establish an assay for the detection of autoimmune sera with broad spectrum activity, we have investigated the effect of unselected normal and Graves' disease sera upon steroidogenesis by gonadal cells. Steroidogenesis was enhanced by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b94818725b7867bdc7f7cd97cefa96
https://doi.org/10.1016/0165-0378(93)90035-g
https://doi.org/10.1016/0165-0378(93)90035-g
Publikováno v:
Journal of reproductive immunology. 30(1)
Graves' disease is attributed to the presence of autoantibodies with agonist activity which interact with the TSH receptor causing thyroid hyperstimulation and hyperthyroidism. The degree of TSH-binding inhibition (TSH-BI) caused by a Graves' serum i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7f1752726162cfbd440c4a4145be01
https://pubmed.ncbi.nlm.nih.gov/8920164
https://pubmed.ncbi.nlm.nih.gov/8920164
Publikováno v:
Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 104
With the aid of recombinant DNA technology (PCR/site directed mutagenesis, sequencing) the full length coding region of the human TSH receptor was manipulated to place a specific epitope peptide tag (FLAG epitope sequence) at the carboxyl end of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5e9ed4f8cc2e28fc653fb43386359c
https://pubmed.ncbi.nlm.nih.gov/8981002
https://pubmed.ncbi.nlm.nih.gov/8981002
Autor:
K. P. Willey, N. Hunt
Publikováno v:
Schilddrüse 1993
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcc746602a5f59f8628bcad1a7d1c695
https://doi.org/10.1515/9783110883138-003
https://doi.org/10.1515/9783110883138-003
Autor:
Marga Balvers, Detlev Jähner, Nicholas Hunt, Richard Ivell, Nicole Abend, K. P. Willey, Wolfgang Northemann
Publikováno v:
Endocrine. 3(3)
The thyrotropin receptor is of fundamental importance to normal thyroid function and is considered to be the predominant antigen affected by the autoantibodies of Graves' autoimmune hyperthyroidism. The identification of the epitopes on the receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9949178f45fd00433894810d7e3e10
https://pubmed.ncbi.nlm.nih.gov/21153200
https://pubmed.ncbi.nlm.nih.gov/21153200
Autor:
K. P. Willey, W. Northemann, Nicholas Hunt, Freimut A. Leidenberger, Richard Ivell, M.A. Castel, Detlev Jähner
Publikováno v:
Experimental and clinical endocrinology. 100(1-2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ea83ab6c3da9ab94b546021c922e00
https://pubmed.ncbi.nlm.nih.gov/1468510
https://pubmed.ncbi.nlm.nih.gov/1468510
Publikováno v:
Journal of Endocrinology. 106:387-394
The role of melatonin in animals which do not show marked seasonal changes in reproduction is disputed, in part because of the wide variation in reported concentrations. One reason for this may be the difficulties associated with the measurement of l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e8fb63c4a7bc0565d62f91dfcc73ef
https://doi.org/10.1677/joe.0.1060387
https://doi.org/10.1677/joe.0.1060387
Autor:
K P Willey, F Leidenberger
Publikováno v:
Journal of Biological Chemistry. 264:19716-19729
The histidine residues in human chorionic gonadotropin (hCG) were chemically modified using diethyl pyrocarbonate. Derivatives of hCG with an average of 0.5-3.5 histidines modified (maximum of 4 per hCG) had reduced receptor-binding and cell-stimulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d201fba2177616321436231e37e88771
https://doi.org/10.1016/s0021-9258(19)47172-x
https://doi.org/10.1016/s0021-9258(19)47172-x