Zobrazeno 1 - 10
of 28
pro vyhledávání: '"K. P. Parmar"'
Autor:
Babak Choodari-Oskooei, Alexandra Blenkinsop, Kelly Handley, Thomas Pinkney, Mahesh K. B. Parmar
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Multi-arm multi-stage (MAMS) randomised trial designs have been proposed to evaluate multiple research questions in the confirmatory setting. In designs with several interventions, such as the 8-arm 3-stage ROSSINI-2 trial for pre
Externí odkaz:
https://doaj.org/article/f169275c95354f73bdb833b5346d695c
Publikováno v:
Implementation Science, Vol 19, Iss 1, Pp 1-19 (2024)
Abstract Background It is unclear how to disseminate the results of randomised controlled trials effectively to health professionals and policymakers to improve treatment, care or prevention through changing policy and practice. This systematic revie
Externí odkaz:
https://doaj.org/article/a9fe7921b98d4711badf63756c7450f4
Autor:
Babak Choodari‑Oskooei, Alexandra Blenkinsop, Kelly Handley, Thomas Pinkney, Mahesh K. B. Parmar
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/c6cbea8f999a4321b647537ca534cf9e
Autor:
Richard A. Parker, Christopher J. Weir, Tra My Pham, Ian R. White, Nigel Stallard, Mahesh K. B. Parmar, Robert J. Swingler, Rachel S. Dakin, Suvankar Pal, Siddharthan Chandran
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background MND-SMART is a platform, multi-arm, multi-stage, multi-centre, randomised controlled trial recruiting people with motor neuron disease. Initially, the treatments memantine and trazodone will each be compared against placebo, but o
Externí odkaz:
https://doaj.org/article/79ee44339d2044749471abb674bbc6f1
Autor:
Emily Grist, Stefanie Friedrich, Christopher Brawley, Larissa Mendes, Marina Parry, Adnan Ali, Aine Haran, Alex Hoyle, Claire Gilson, Sharanpreet Lall, Leila Zakka, Carla Bautista, Alex Landless, Karolina Nowakowska, Anna Wingate, Daniel Wetterskog, A. M. Mahedi Hasan, Nafisah B. Akato, Malissa Richmond, Sofeya Ishaq, Nik Matthews, Anis A. Hamid, Christopher J. Sweeney, Matthew R. Sydes, Daniel M. Berney, Stefano Lise, STAMPEDE investigators, Mahesh K. B. Parmar, Noel W. Clarke, Nicholas D. James, Paolo Cremaschi, Louise C. Brown, Gerhardt Attard
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-15 (2022)
Abstract Background Genomic copy number alterations commonly occur in prostate cancer and are one measure of genomic instability. The clinical implication of copy number change in advanced prostate cancer, which defines a wide spectrum of disease fro
Externí odkaz:
https://doaj.org/article/506e0f56118040028d430cc8873797f0
Autor:
Sharon B. Love, Fay Cafferty, Claire Snowdon, Karen Carty, Joshua Savage, Philip Pallmann, Lucy McParland, Louise Brown, Lindsey Masters, Francesca Schiavone, Dominic Hague, Stephen Townsend, Claire Amos, Annabelle South, Kate Sturgeon, Ruth Langley, Timothy Maughan, Nicholas James, Emma Hall, Sarah Kernaghan, Judith Bliss, Nick Turner, Andrew Tutt, Christina Yap, Charlotte Firth, Anthony Kong, Hisham Mehanna, Colin Watts, Robert Hills, Ian Thomas, Mhairi Copland, Sue Bell, David Sebag-Montefiore, Robert Jones, Mahesh K. B. Parmar, Matthew R. Sydes
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Late-phase platform protocols (including basket, umbrella, multi-arm multi-stage (MAMS), and master protocols) are generally agreed to be more efficient than traditional two-arm clinical trial designs but are not extensively used.
Externí odkaz:
https://doaj.org/article/f16f51eff76c45b9b2545597e35df8a3
Autor:
A J DHAMI, M R CHAVDA, K B VALA, R J RAVAL, V K KARANGIYA, J K CHAUDHARY, K H PARMAR, B D SAVALIYA
Publikováno v:
Indian Journal of Animal Sciences, Vol 92, Iss 12 (2022)
The study evaluated the effect of supplementation of rumen protected choline (RPC) and fat (RPF) alone and in combination, and injection Vit-E + selenium on feed intake, blood metabolic profile and postpartum fertility in transition Gir cows. Forty a
Externí odkaz:
https://doaj.org/article/d499d901de444fa2b8297ace6e2aabca
Autor:
Jeremy Chataway, Suvankar Pal, Charis Wong, Elizabeth Elliott, Jenna M Gregory, Siddharthan Chandran, Judith Newton, Shuna Colville, Maria Stavrou, Christopher J Weir, Nigel Stallard, Malcolm R Macleod, Michelle Steven, Richard Anthony Parker, Arpan R Mehta, Robert J Swingler, Mahesh K B Parmar, Rachel S Dakin, Jill Williamson
Publikováno v:
BMJ Open, Vol 12, Iss 7 (2022)
Introduction Motor neuron disease (MND) is a rapidly fatal neurodegenerative disease. Despite decades of research and clinical trials there remains no cure and only one globally approved drug, riluzole, which prolongs survival by 2–3 months. Recent
Externí odkaz:
https://doaj.org/article/5e965243774d4c02bc888f34d9e8e037
Autor:
Archie Macnair, Sharon B. Love, Macey L. Murray, Duncan C. Gilbert, Mahesh K. B. Parmar, Tom Denwood, James Carpenter, Matthew R. Sydes, Ruth E. Langley, Fay H. Cafferty
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Routinely collected electronic health records (EHRs) have the potential to enhance randomised controlled trials (RCTs) by facilitating recruitment and follow-up. Despite this, current EHR use is minimal in UK RCTs, in part due to
Externí odkaz:
https://doaj.org/article/b1921d19946446b7802947c78af104a7
Autor:
Chris C. Parker, Nicholas D. James, Christopher D. Brawley, Noel W. Clarke, Adnan Ali, Claire L. Amos, Gerhardt Attard, Simon Chowdhury, Adrian Cook, William Cross, David P. Dearnaley, Hassan Douis, Duncan C. Gilbert, Clare Gilson, Silke Gillessen, Alex Hoyle, Rob J. Jones, Ruth E. Langley, Zafar I. Malik, Malcolm D. Mason, David Matheson, Robin Millman, Mary Rauchenberger, Hannah Rush, J Martin Russell, Hannah Sweeney, Amit Bahl, Alison Birtle, Lisa Capaldi, Omar Din, Daniel Ford, Joanna Gale, Ann Henry, Peter Hoskin, Mohammed Kagzi, Anna Lydon, Joe M. O’Sullivan, Sangeeta A. Paisey, Omi Parikh, Delia Pudney, Vijay Ramani, Peter Robson, Narayanan Nair Srihari, Jacob Tanguay, Mahesh K. B. Parmar, Matthew R. Sydes, for the STAMPEDE Trial Collaborative Group
Publikováno v:
PLoS Medicine, Vol 19, Iss 6 (2022)
Background STAMPEDE has previously reported that radiotherapy (RT) to the prostate improved overall survival (OS) for patients with newly diagnosed prostate cancer with low metastatic burden, but not those with high-burden disease. In this final anal
Externí odkaz:
https://doaj.org/article/59bd277f4a854b248d9e56e359be5b75