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Derivatives of 2-mercaptobenzenesulphonamide. XX. Synthesis and cardiovascular effects of some 2-[4-chloro-2-(2-dialkylaminoethylthio)-5-methylbenzenesulphonylimino]- perhydropyrimidines

Autor: E, Pomarnacka, K, Oledzka

Publikováno v: Acta poloniae pharmaceutica. 53(6)

A series of 2-[4-chloro-2-(2-dialkylaminoethylthio)-5-methyl- benzenesulphonylimino]perhydropyrimidines [IV-X] and their hydrochlorides [IVa-VIIIa] were prepared. The antiarrhythmic effect of the most active compound [Va] was comparable to the refere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77febcc52e5ab3506d2d1ad7ac192bd9
https://pubmed.ncbi.nlm.nih.gov/9415219

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Derivatives of 2-mercaptobenzenesulphonamide. XXI. Syntheses and cardiovascular effects of N-(dimethylaminoethyl)amides of 2-(perhydropyrimidin-2-yliminosulphonyl)-phenylthioalkanoic acids

Autor: E, Pomarnacka, K, Oledzka

Publikováno v: Acta poloniae pharmaceutica. 53(6)

A series of 2-[5-chloro-4-methyl-2-(perhydropyrimidin-2-yl iminosulphonyl)phenylthio]alkanoic acids [IV-XI], their methyl esters [XII-XIX], N-(2-dimethylaminoethyl) amides, [XX-XXV] and the corresponding hydrochlorides [XXa-XXIVa] were obtained. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::66bf5a008964c70f1f438dee3e4b36f0
https://pubmed.ncbi.nlm.nih.gov/9415220

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Derivatives of 2-mercaptobenzenesulphonamide. XVIII. Syntheses and cardiovascular effects of some S- and S,N-substituted 4-chloro-2-mercapto-5-methyl-N-(5-amino-1,2,4-triazol-3-yl) benzenesulphonamide derivatives

Autor: Z, Brzozowski, E, Pomarnacka, K, Oledzka, M, Filczewski

Publikováno v: Acta poloniae pharmaceutica. 52(3)

The syntheses of salts [III, IV] and amides [V, V.HCl] of 2-[5-chloro-4-methyl-2-[(5-amino-s-triazol-3-yl)aminosulphonyl+ ++] phenylthio] alkanoic acids, as well as 5-amino-2-[2-(2,4-dimethylpiperidino) ethyl]-3-[4-chloro-2-[2-(2,6-dimethylpiperidino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::474f7e58884f4eb16e9e725199f1c302
https://pubmed.ncbi.nlm.nih.gov/8960253

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Influence of coenzyme Q-10 on the hypotensive effects of enalapril and nitrendipine in spontaneously hypertensive rats

Autor: A, Danysz, K, Oledzka, M, Bukowska-Kiliszek

Publikováno v: Polish journal of pharmacology. 46(5)

Administration of coenzyme Q-10 (10 mg/kg) once a day for 4 weeks decreased the arterial blood pressure in SHR's. Enalapril and nitrendipine administered in a single dose caused significant decrease of blood pressure. Application of enalapril and nit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e29e62b9bbbf1b70d81114c6f47fc330
https://pubmed.ncbi.nlm.nih.gov/7894534

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Derivatives of 2-mercaptobenzenesulphonamide. XVII. Synthesis and some pharmacological properties of 1-[4-R-5-cyano-2-dialkylaminoalkylthio)benzenesulphonyl]-2-imidiazolidi none hydrochlorides

Autor: E, Pomarnacka, Z, Brzozowski, F, Gajewski, M, Filczewski, K, Oledzka, M, Kosmala, M, Sliwoska

Publikováno v: Acta poloniae pharmaceutica. 51(4-5)

Syntheses of 1-[4-R-5-cyano-2-(dialkylaminoalkylthio)-benzenesulphonyl]- 2-imidiazolidinones [IIIa-h,IVa-m] and their hydrochlorides [Va-h, VIa-m] are described herein. The results of preliminary pharmacological examinations, such as acute toxicity a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7c353f2ee546db8e69a722ad214e9b1
https://pubmed.ncbi.nlm.nih.gov/7701953

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Derivatives of 2-mercaptobenzenesulphonamide. XII. Synthesis and some pharmacological properties of 2-(2-mercaptobenzenesulphonyl)imidazoline

Autor: Z, Brzozowski, J, Sławiński, K, Oledzka, M, Kosmala, K, Lewandowski, M, Filczewski, J, Miłobedzka

Publikováno v: Acta poloniae pharmaceutica. 50(4-5)

Synthesis of 2-[2 (alkylaminoalkylthio)-4-R1-5-R2-benzenesulphonamide]-5-R3-im idazoline [IV-IX], their hydrochlorides [IVa-IXa], as well needful substrates [IIc, III] are described. The results of preliminary pharmacological examinations such as acu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59215389f0f725fac973ad10f44fa31c
https://pubmed.ncbi.nlm.nih.gov/8036921

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Derivatives of 2-mercaptyobenzenesulphonamide. XIII. Syntheses and somepharmacological properties of 1-4-chloro-2-(dialkylaminoalkylthio)-5- methylbenzenesulphonyl)-2-imidazolidinone hydrochlorides

Autor: Z, Brzozowski, E, Pomarnacka, M, Kosmala, M, Filczewski, K, Oledzka, K, Lewandowski, J, Miłobedzka

Publikováno v: Acta poloniae pharmaceutica. 50(4-5)

Syntheses of 1-[4-chloro-2-(dialkylaminoalkylthio)-5- methylbenzenesulphonyl]-2-imidazolidones [II-X] and their hydrochlorides [IIa-Xa] are described. The results of preliminary pharmacological examination such as acute toxicity and influence on circ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c5c3d029abbcae23ea64e4c99ef11e3
https://pubmed.ncbi.nlm.nih.gov/8036922

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Pharmacological properties of the extract of thymus gland (Thymomodulin-TFX) and its effect on reproduction

Autor: M, Kosmala, K, Oledzka, M, Kaszczyńska, K, Lewandowski, B, Przemyk, M, Filczewski, M, Sliwoska

Publikováno v: Acta poloniae pharmaceutica. 50(6)

The effect of Thymomodulin-TFX on pentetrazole convulsions, tremorine-induced tremor, pain response to intraperitoneal acetic acid injection, hexobarbital sleeping time, isolated guinea pig ileum, isolated rat uterus, rabbit skeletal muscle response,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3767fc12d771110c513f69fb0f406df
https://pubmed.ncbi.nlm.nih.gov/8067258

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Derivatives of 2-mercaptobenzenesulphonamide. XI. Synthesis and some pharmacological properties of 2-(2-[2-(3,4,5-trimethoxybenzamido)ethylthio] benzenesulphonyl) guanidines

Autor: Z, Brzozowski, J, Sławiński, K, Oledzka, M, Kosmala, M, Filczewski, K, Lewandowski, J, Miłobedzka

Publikováno v: Acta poloniae pharmaceutica. 50(4-5)

Tree methods of synthesis of 2-(2-[2-(3,4,5-trimethoxybenzamido)ethylthio] benzenesulphonyl)guanidines (IVa-b, Va-XIVa, VIII-XII) are described. The results of preliminary pharmacological examinations such as acute toxicity and influence on circulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd33b46286223fbe2a9aae20649aad89
https://pubmed.ncbi.nlm.nih.gov/8036920

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