Zobrazeno 1 - 10
of 473
pro vyhledávání: '"K. Ohsumi"'
Autor:
Toshiro K. Ohsumi, Kevin R. Brown, Henry N. Ward, Michael Aregger, Chad L. Myers, Thomas Gonatopoulos-Pournatzis, Maximilian Billmann, Jason Moffat, Benjamin J. Blencowe
Publikováno v:
Nat Protoc
The continued improvement of combinatorial CRISPR screening platforms necessitates the development of new computational pipelines for scoring combinatorial screening data. Unlike for single-guide RNA (sgRNA) pooled screening platforms, combinatorial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3148aff1828740f795d86f14a08046e3
https://doi.org/10.1038/s41596-021-00596-0
https://doi.org/10.1038/s41596-021-00596-0
Autor:
Chih-Chi Yuan, Adam G.W. Matthews, Yi Jin, Chang Feng Chen, Brad A. Chapman, Toshiro K. Ohsumi, Karen C. Glass, Tatiana G. Kutateladze, Mark L. Borowsky, Kevin Struhl, Marjorie A. Oettinger
Publikováno v:
Cell Reports, Vol 1, Iss 2, Pp 83-90 (2012)
The preferential in vitro interaction of the PHD finger of RAG2, a subunit of the V(D)J recombinase, with histone H3 tails simultaneously trimethylated at lysine 4 and symmetrically dimethylated at arginine 2 (H3R2me2sK4me3) predicted the existence o
Externí odkaz:
https://doaj.org/article/e46ba8feaf1a47d5b204e25042cea6ef
Autor:
Nicole Hustedt, Henrique Melo, Dheva Setiaputra, Jessica Desjardins, Artur Veloso, Rachel K. Szilard, Shou Yun Yin, Alejandro Álvarez-Quilón, Michael Zinda, Timothy F. Ng, Meagan Munro, Robert Papp, Daniel Durocher, Mara De Marco Zompit, Yibo Xue, Giovanni Martino, Jordan T.F. Young, Nathalie Moatti, Salomé Adam, Natasha Chaudhary, Vivek Bhaskaran, Manuel Stucki, Sylvie M. Noordermeer, Toshiro K. Ohsumi, Silvia Emma Rossi
Publikováno v:
Nature Cancer, 2(12), 1357-+. NATURE PORTFOLIO
BRCA1/2-mutated cancer cells adapt to the genome instability caused by their deficiency in homologous recombination (HR). Identification of these adaptive mechanisms may provide therapeutic strategies to target tumors caused by the loss of these gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9275bd317b6ceebb275c11ab3f1a0320
https://doi.org/10.5167/uzh-216678
https://doi.org/10.5167/uzh-216678
Akademický článek
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Autor:
Raif S. Geha, Juan Manuel Leyva Castillo, Janet Chou, Fatma Dedeoglu, Jeff Goldsmith, Wayne Bainter, Yousef R. Badran, Athos Bousvaros, Toshiro K. Ohsumi
Publikováno v:
The Journal of Experimental Medicine
Badran et al. demonstrate an essential contribution of biallelic RELA expression in protecting stromal and epithelial cells from TNF-mediated cell death in patients with chronic mucocutaneous ulceration.
The treatment of chronic mucocutaneous ul
The treatment of chronic mucocutaneous ul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d84a9f625fb5a3d2085db5660f71633
http://europepmc.org/articles/PMC5502421
http://europepmc.org/articles/PMC5502421
Autor:
Anant Vatsayan, Fedik Rahimov, Waleed Al-Herz, Colin A. Sieff, Mark D. Fleming, Basel K. al-Ramadi, E. Graham Davies, Michel J. Massaad, Martha Sola-Visner, Raif S. Geha, Narayanaswamy Ramesh, Haifa H. Jabara, Nancy C. Andrews, Wayne Bainter, Eli Silver, David Fraulino, Steven E. Boyden, Rand Arnaout, Salem H. Alshemmari, Sanjay P Ahuja, Louis M. Kunkel, Hasan Al-Dhekri, Mohammad Abu-Shukair, Zhi-Jian Liu, Janet Chou, Toshiro K. Ohsumi, Halli Benson, Luigi D. Notarangelo
Publikováno v:
Nature Genetics. 48:74-78
Patients with a combined immunodeficiency characterized by normal numbers but impaired function of T and B cells had a homozygous p.Tyr20His substitution in transferrin receptor 1 (TfR1), encoded by TFRC. The substitution disrupts the TfR1 internaliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554a57ef01a1e625821aeae18c7a69a3
https://doi.org/10.1038/ng.3465
https://doi.org/10.1038/ng.3465
Autor:
Josien C. van Wolfswinkel, Peter C. Breen, Martin A. Newman, Brooke E Montgomery, Elke F. Roovers, René F. Ketting, Toshiro K. Ohsumi, Young-Soo Rim, Carolyn M. Phillips, Gary Ruvkun, Taiowa A. Montgomery
Publikováno v:
Current Biology
Summary More than 2,000 C. elegans genes are targeted for RNA silencing by the mutator complex, a specialized small interfering RNA (siRNA) amplification module which is nucleated by the Q/N-rich protein MUT-16. The mutator complex localizes to Mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66138937a6bbcb3ccc776bc5acd60d6e
Autor:
Joseph El Khoury, Nathan D. Kingery, Li-chong Wang, Suzanne E. Hickman, Mark L. Borowsky, Toshiro K. Ohsumi, Terry K. Means
Publikováno v:
Nature neuroscience
Microglia, the principal neuroimmune sentinels of the brain, continuously sense changes in their environment and respond to invading pathogens, toxins and cellular debris. Microglia exhibit plasticity and can assume neurotoxic or neuroprotective prim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b09920f63535c164b4cab5b82e2eff5
https://doi.org/10.1038/nn.3554
https://doi.org/10.1038/nn.3554
Autor:
Francesco Ferrari, Jose M. Polo, Peter J. Park, Effie Apostolou, Matthias Stadtfeld, Hannah T. Stuart, Sihem Cheloufi, Toshiro K. Ohsumi, Ori Bar-Nur, Mark L. Borowsky, Peter V. Kharchenko, Ryan M. Walsh, Konrad Hochedlinger
Publikováno v:
Cell Cycle
While the chromatin state of pluripotency genes has been extensively studied in embryonic stem cells (ESCs) and differentiated cells, their potential interactions with other parts of the genome remain largely unexplored. Here, we identified a genome-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::addcf08e9d3a2ee3c34ea467efcb4e43
Publikováno v:
Current Opinion in Allergy & Clinical Immunology. 12:623-628
Purpose of review This review discusses the strengths and challenges of using whole genome sequencing (WGS)/whole exome sequencing (WES) for identifying novel genetic causes of primary immunodeficiencies. Recent findings WGS permits comprehensive seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ef1a97fe2118d0ac4956b0991d9b1a
https://doi.org/10.1097/aci.0b013e3283588ca6
https://doi.org/10.1097/aci.0b013e3283588ca6