Zobrazeno 1 - 10
of 62
pro vyhledávání: '"K. O. Vollmer"'
Autor:
L L, Radulovic, D, Türck, A, von Hodenberg, K O, Vollmer, W P, McNally, P D, DeHart, B J, Hanson, H N, Bockbrader, T, Chang
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(4)
Gabapentin, an analog of gamma-aminobutyric acid, exhibits anticonvulsant properties in both animal models and humans. Gabapentin pharmacokinetics was studied in laboratory animals using HPLC and radiometry. Oral bioavailability was 40% in monkeys ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0101006a48980bad24b1192cc0b31cca
https://pubmed.ncbi.nlm.nih.gov/7600909
https://pubmed.ncbi.nlm.nih.gov/7600909
Publikováno v:
Pain. 41:S461
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04cc662e2e15cc18bc48f86d413104c5
https://doi.org/10.1016/0304-3959(90)93037-x
https://doi.org/10.1016/0304-3959(90)93037-x
Publikováno v:
Clinical Chemistry. 24:692-697
We report a specific and sensitive method for determination of the individual optical isomers of nortilidine, a main metabolite of tilidine, with the aid of a nitrogen-sensitive detector. With N-trifluoroacetyl-L-leucyl chloride as chiral reagent, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecb41f80a86227332373abf5d27aecca
https://doi.org/10.1093/clinchem/24.4.692
https://doi.org/10.1093/clinchem/24.4.692
Publikováno v:
Journal of Pharmaceutical Sciences. 67:1765-1768
A sensitive and specific GLC method is described to determine therapeutic levels of tilidine and its two main metabolites, nortilidine and bisnortilidine, in plasma and urine. The method involves the extraction of the compounds and an internal standa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb3411590aea3cfea16ece05c8210688
https://doi.org/10.1002/jps.2600671237
https://doi.org/10.1002/jps.2600671237
Autor:
K.-O. Vollmer, B. Liedtke
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 14:825-833
Ausgehend von Bariumcarbonat-C wurde N-(2-Diathylaminoathy1)-S,S-diphenyl-sulfoximin in 8 Stufen in Position 1 der Seitenkette radioaktiv markiert (IA). Bezogen auf die Ausgangssubstanz betrug die radiochemische Ausbeute 44,6%. Zur Markierung in den
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb1d72d150f88af74ae18a15b2c2b632
https://doi.org/10.1002/jlcr.2580140606
https://doi.org/10.1002/jlcr.2580140606
Publikováno v:
European Journal of Clinical Pharmacology. 4:92-98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c11d6c5536157251c4b6200bfafeffc2
https://doi.org/10.1007/bf00562503
https://doi.org/10.1007/bf00562503
Synthese von DL-1-(3′-hydroxyphenyl)-2-aminoäthanol-hydrochlorid-(2-14C [norfenefrin HCL, novadral®]
Autor:
B. Liedtke, K.-O Vollmer
Publikováno v:
Journal of Labelled Compounds. 9:347-353
DL-1-(3′-Hydroxyphenyl)-2-aminoathanol-hydrochlorid- (2-14C) wurde ausgehend von Kupfercyanid-14C in einer 2-Stufen-Synthese mit guter Ausbeute dargestellt. Dieser Syntheseweg ist auch zur 14C-Markierung anderer 1-Aryl-2-aminoathanole in Position 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bf728f7761967c5f0650982371768c3
https://doi.org/10.1002/jlcr.2590090219
https://doi.org/10.1002/jlcr.2590090219
Publikováno v:
European Journal of Clinical Pharmacology. 4:104-106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1a6f9cd0a00326ae7ebf90041885e87
https://doi.org/10.1007/bf00562505
https://doi.org/10.1007/bf00562505
Autor:
G, Friedrich, K O, Vollmer
Publikováno v:
Arzneimittel-Forschung. 27(2b)
Studies of hexobarbital sleeping time in rats showed that only a very high dosage of ethyl(Z)-(3-ethyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)-acetate (piprozoline, Gö 919, Problin) (500 mg/kg) produced a weak interaction with the metabolism of he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ec448497c42f184197c14d9b87f004c
https://pubmed.ncbi.nlm.nih.gov/577415
https://pubmed.ncbi.nlm.nih.gov/577415
Publikováno v:
Clinical chemistry. 24(4)
We report a specific and sensitive method for determination of the individual optical isomers of nortilidine, a main metabolite of tilidine, with the aid of a nitrogen-sensitive detector. With N-trifluoroacetyl-L-leucyl chloride as chiral reagent, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d5bfb25fff19b04d9c46d3d620a905d
https://pubmed.ncbi.nlm.nih.gov/639277
https://pubmed.ncbi.nlm.nih.gov/639277