Structural and functional characterization of D109H and R69C mutant versions of human αB-crystallin: The biochemical pathomechanism underlying cataract and myopathy development

Autor: A. V. Krivandin, Maryam Ghahramani, K. O. Muranov, Reza Yousefi, Ali Akbar Moosavi-Movahedi, Boris I. Kurganov

Publikováno v: International Journal of Biological Macromolecules. 146:1142-1160

In human αB-crystallin (αB-Cry), the highly conserved residues arginine 69 (R69) and aspartate 109 (D109) are located within a critical motif of α-crystallin domain (ACD), contributing to the subunit interactions and oligomeric assembly. Recently,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02de57a3e25ccc357a1bc6518e05d1f
https://doi.org/10.1016/j.ijbiomac.2019.09.239

The mechanism of the interaction of α-crystallin and UV-damaged βL-crystallin

Autor: S. Yu. Kleimenov, Alexey S. Kononikhin, Maria I. Indeykina, K. O. Muranov, Natalia A. Chebotareva, E. N. Nikolaev, Nikolay B. Poliansky, Anna E. Bugrova, M. A. Ostrovsky

Publikováno v: International Journal of Biological Macromolecules. 140:736-748

α-Crystallin maintains the transparency of the lens by preventing the aggregation of damaged proteins. The aim of our work was to study the chaperone-like activity of native α-crystallin in near physiological conditions (temperature, ionic power, p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cd3d4ad0453e028aa39478e68a9a0cc
https://doi.org/10.1016/j.ijbiomac.2019.08.178

Structural and functional alteration of human αA-crystallin after exposure to full spectrum solar radiation and preventive role of lens antioxidants

Autor: Maryam Ghahramani, Boris I. Kurganov, Afrooz Anbaraki, K. O. Muranov, Reza Yousefi

Publikováno v: International journal of biological macromolecules. 118

The chronically exposure of eye lenses to ultra violet and visible light of the solar radiation is an important risk factor for development of the senile cataract diseases. Various photosensitizer molecules including riboflavin (RF) play a significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd6e3d9b35a513923fddd6853ec3544
https://pubmed.ncbi.nlm.nih.gov/29964111

Kinetics of aggregation of UV-irradiated glyceraldehyde-3-phosphate dehydrogenase from rabbit skeletal muscle. Effect of agents possessing chaperone-like activity

Autor: Boris I. Kurganov, Natalia A. Chebotareva, Sergey Yu. Kleymenov, Valentina F. Makeeva, Nikolay B. Poliansky, Olga I. Maloletkina, Kira A. Markossian, R.A. Asryants, K. O. Muranov

Publikováno v: Biophysical Chemistry. :11-20

An aggregation test system based on the aggregation of UV-irradiated glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from rabbit skeletal muscle has been proposed. On the basis of the measurements of the enzyme activity and differential scanning cal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e070622e895b1808fc7cb75ca11ec6
https://doi.org/10.1016/j.bpc.2012.02.001

Paradoxical Acceleration of Dithiothreitol-Induced Aggregation of Insulin in the Presence of a Chaperone

Autor: Zoya M. Bumagina, Natalya V. Artemova, K. O. Muranov, Boris I. Kurganov, Bella Gurvits

Publikováno v: International Journal of Molecular Sciences, Vol 11, Iss 11, Pp 4556-4579 (2010)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 11; Issue 11; Pages: 4556-4579

The kinetics of dithiothreitol (DTT)-induced aggregation of human recombinant insulin and the effect of α-crystallin, a representative of the family of small heat shock proteins, on the aggregation process have been studied using dynamic light scatt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ac9dd63e992bb5b3fdbb5043f31ca0
http://www.mdpi.com/1422-0067/11/11/4556/