Zobrazeno 1 - 10
of 71
pro vyhledávání: '"K. Nyquist"'
Autor:
Swati Jaiswal, Sarah K. Nyquist, Shayla Boyce, Tasneem Jivanjee, Samira Ibrahim, Joshua D. Bromley, G. James Gatter, Hannah Gideon, Kush Patel, Sharie Keanne Ganchua, Bonnie Berger, Sarah M. Fortune, JoAnne L. Flynn, Alex K. Shalek, Samuel M. Behar
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Cynomolgus macaque (Macaca fascicularis) is an attractive animal model for the study of human disease and is extensively used in biomedical research. Cynomolgus macaques share behavioral, physiological, and genomic traits with hum
Externí odkaz:
https://doaj.org/article/0fcfddea48094cb580d2427baab18647
Autor:
Rabiah Fardoos, Sarah K. Nyquist, Osaretin E. Asowata, Samuel W. Kazer, Alveera Singh, Abigail Ngoepe, Jennifer Giandhari, Ntombifuthi Mthabela, Dirhona Ramjit, Samita Singh, Farina Karim, Søren Buus, Frank Anderson, J. Zachary Porterfield, Andile L. Sibiya, Rishan Bipath, Kumeshan Moodley, Warren Kuhn, Bonnie Berger, Son Nguyen, Tulio de Oliveira, Thumbi Ndung’u, Philip Goulder, Alex K. Shalek, Alasdair Leslie, Henrik N. Kløverpris
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TRM) CD8+ T-cells is of gr
Externí odkaz:
https://doaj.org/article/2214efc1e1c44dd5be878bda8705a958
Autor:
Emily Berger, Deniz Yorukoglu, Lillian Zhang, Sarah K. Nyquist, Alex K. Shalek, Manolis Kellis, Ibrahim Numanagić, Bonnie Berger
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Haplotype reconstruction of distant genetic variants is problematic in short-read sequencing. Here, the authors describe HapTree-X, a probabilistic framework that uses differential allele-specific expression to better reconstruct paternal haplotypes
Externí odkaz:
https://doaj.org/article/c970eb7c1f7e4e68975f9e9fac639d5d
Autor:
Rabiah Fardoos, Osaretin E. Asowata, Nicholas Herbert, Sarah K. Nyquist, Yenzekile Zungu, Alveera Singh, Abigail Ngoepe, Ian M. Mbano, Ntombifuthi Mthabela, Dirhona Ramjit, Farina Karim, Warren Kuhn, Fusi G. Madela, Vukani T. Manzini, Frank Anderson, Bonnie Berger, Tune H. Pers, Alex K. Shalek, Alasdair Leslie, Henrik N. Kløverpris
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
SARS-CoV-2 infects epithelial cells of the human gastrointestinal (GI) tract and causes related symptoms. HIV infection impairs gut homeostasis and is associated with an increased risk of COVID-19 fatality. To investigate the potential link between t
Externí odkaz:
https://doaj.org/article/393306dcc3c24409b817c7996c447f25
Autor:
Julien Olivet, Soon Gang Choi, Salvador Sierra, Tina M. O’Grady, Mario de la Fuente Revenga, Florent Laval, Vladimir V. Botchkarev, Christoph Gorgulla, Paul W. Coote, Jérémy Blavier, Ezekiel A. Geffken, Jimit Lakhani, Kijun Song, Zoe C. Yeoh, Bin Hu, Anthony C. Varca, Jonathan Bruyr, Samira Ibrahim, Tasneem Jivanjee, Joshua D. Bromley, Sarah K. Nyquist, Aaron Richardson, Hong Yue, Yang Wang, Natalia Calonghi, Alessandra Stefan, Kerstin Spirohn, Didier Vertommen, Maria F. Baietti, Irma Lemmens, Hyuk-Soo Seo, Mikhail G. Dozmorov, Luc Willems, Jan Tavernier, Kalyan Das, Eleonora Leucci, Alejandro Hochkoeppler, Zhen-Yu Jim Sun, Michael A. Calderwood, Tong Hao, Alex K. Shalek, David E. Hill, Andras Boeszoermenyi, Haribabu Arthanari, Sara J. Buhrlage, Sirano Dhe-Paganon, Javier González-Maeso, Franck Dequiedt, Jean-Claude Twizere, Marc Vidal
Enzymatic pockets such as those of histone deacetylases (HDACs) are among the most favored targets for drug development. However, enzymatic inhibitors often exhibit low selectivity and high toxicity due to targeting multiple enzyme paralogs, which ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8635e9e2aa438eb8f00e273e12bf49c9
https://doi.org/10.1101/2022.12.07.519454
https://doi.org/10.1101/2022.12.07.519454
Autor:
Sarah K. Nyquist, Ibrahim Numanagić, Deniz Yorukoglu, Emily Berger, Bonnie Berger, Manolis Kellis, Lillian Zhang, Alex K. Shalek
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Haplotype reconstruction of distant genetic variants remains an unsolved problem due to the short-read length of common sequencing data. Here, we introduce HapTree-X, a probabilistic framework that utilizes latent long-range information to reconstruc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc95e601830005e1de9c1f195189345a
http://link.springer.com/article/10.1038/s41467-020-18320-z
http://link.springer.com/article/10.1038/s41467-020-18320-z
Autor:
Samuel W. Kazer, Alex K. Shalek, Mary Dong, J. Christopher Love, Sarah K. Nyquist, Shaina L. Carroll, Alasdair Leslie, Amber Moodley, Jose Ordovas-Montanes, Toby Aicher, Emily B. Wong, Krista L. Dong, Zaza M. Ndhlovu, Carly G. K. Ziegler, Vincent N. Miao, Nasreen Ismail, Thumbi Ndung'u, Daniel M. Muema, Ang A. Tu, Bruce D. Walker, Bonnie Berger
Publikováno v:
Nature Medicine
Nat Med
Nat Med
Cellular immunity is critical for controlling intracellular pathogens, but individual cellular dynamics and cell–cell cooperativity in evolving human immune responses remain poorly understood. Single-cell RNA-sequencing (scRNA-seq) represents a pow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b6d6ff066fb06a363149e07e3c0e6c
https://doi.org/10.1038/s41591-020-0799-2
https://doi.org/10.1038/s41591-020-0799-2
Autor:
Rabiah, Fardoos, Sarah K, Nyquist, Osaretin E, Asowata, Samuel W, Kazer, Alveera, Singh, Abigail, Ngoepe, Jennifer, Giandhari, Ntombifuthi, Mthabela, Dirhona, Ramjit, Samita, Singh, Farina, Karim, Søren, Buus, Frank, Anderson, J Zachary, Porterfield, Andile L, Sibiya, Rishan, Bipath, Kumeshan, Moodley, Warren, Kuhn, Bonnie, Berger, Son, Nguyen, Tulio, de Oliveira, Thumbi, Ndung'u, Philip, Goulder, Alex K, Shalek, Alasdair, Leslie, Henrik N, Kløverpris
Publikováno v:
Frontiers in immunology. 13
Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TsubRM/sub) CD8sup+/supT-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1f56c5e989ab6c4a00d40e98dc97791
https://pubmed.ncbi.nlm.nih.gov/36330531
https://pubmed.ncbi.nlm.nih.gov/36330531
Autor:
Tasneem Jivanjee, Samira Ibrahim, Sarah K. Nyquist, G. James Gatter, Joshua D. Bromley, Swati Jaiswal, Bonnie Berger, Samuel M. Behar, J. Christopher Love, Alex K. Shalek
Publikováno v:
Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071627112
Methods in Molecular Biology ISBN: 9781071627112
Antigen-specific T cells play an essential role in immunoregulation and diseases such as cancer. Characterizing the T cell receptor (TCR) sequences that encode T cell specificity is critical for elucidating the antigenic determinants of immunological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35388076d2c9051ad2167e8112e35028
http://arxiv.org/abs/2203.11266
http://arxiv.org/abs/2203.11266
Autor:
Sarah K. Nyquist, Alex K. Shalek, Bonnie Berger, P. Gao, Kellie E. Kolb, Riley Drake, Brittany A. Goods, Benjamin E. Mead, Micaela E. Martinez, Y. Golan Maor, N. Ahituv, T. K. J. Haining, M. R. Retchin
Human breast milk is a dynamic fluid that contains millions of cells, but their identities and phenotypic properties are poorly understood. We used single-cell RNA-seq (scRNA-seq) to characterize the transcriptomes of cells from human breast milk (hB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb540b00ac84362f25fb8ce524703cd6
https://doi.org/10.1101/2021.11.13.468496
https://doi.org/10.1101/2021.11.13.468496