Zobrazeno 1 - 10
of 26
pro vyhledávání: '"K. Nollstadt"'
Autor:
Sarah Dreikorn, Ken Bartizal, George K. Abruzzo, Black Regina M, K Nollstadt, James M. Balkovec
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2879-2884
A series of pneumocandin B 0 analogs substituted at the 3′ -position of the homotyrosine (Hty) residue have been prepared and evaluated for their inhibition of 1,3-β-( d )-glucan synthesis and for their antifungal activity against C. albicans . Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6004339d7e31e9ad14587434da882b63
https://doi.org/10.1016/s0960-894x(97)10107-x
https://doi.org/10.1016/s0960-894x(97)10107-x
Autor:
James A. Milligan, Cameron M. Douglas, W Li, Bartizal Kenneth F, Amy M. Flattery, Myra B. Kurtz, George K. Abruzzo, K Nollstadt, Jean A. Marrinan
Publikováno v:
Infection and Immunity. 64:3244-3251
The pneumocandins are potent antifungal agents of the echinocandin class which are under development for use as broad-spectrum antimycotic therapy. One important consideration for any new therapeutic class for treating serious fungal infections is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4955a0241a45c7165593c8c1703ec42a
https://doi.org/10.1128/iai.64.8.3244-3251.1996
https://doi.org/10.1128/iai.64.8.3244-3251.1996
Autor:
James M. Balkovec, George K. Abruzzo, Ken Bartizal, Black Regina M, Sarah Dreikorn, K Nollstadt
Publikováno v:
ChemInform. 29
A series of pneumocandin B 0 analogs substituted at the 3′ -position of the homotyrosine (Hty) residue have been prepared and evaluated for their inhibition of 1,3-β-( d )-glucan synthesis and for their antifungal activity against C. albicans . Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d08082108c690c2847b01e79b5b50d0f
https://doi.org/10.1002/chin.199810219
https://doi.org/10.1002/chin.199810219
Autor:
D Krupa, Charlotte Trainor, K Nollstadt, Robert E. Schwartz, James M. Balkovec, Vanmiddlesworth Frank L, Dennis M. Schmatz, Milton L. Hammond, Bartizal Kenneth F, George K. Abruzzo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:1648-1657
The in vivo anti-Candida activities of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991 (cilofungin), L-687,901 (tetrahydroechinocandin B), and L-687,781 (a papulacandin analog) were evaluated by utilizing a murine model of disseminated ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fd89c879d71764e28ce0e9852cbf2f
https://doi.org/10.1128/aac.36.8.1648
https://doi.org/10.1128/aac.36.8.1648
Autor:
Dennis M. Schmatz, James V. Heck, Milton L. Hammond, Charlotte Trainor, K Nollstadt, Robert A. Zambias, George K. Abruzzo, Ken Bartizal
Publikováno v:
Journal of Medicinal Chemistry. 35:2843-2855
The echinocandins are a well-known class of lipopeptides characterized by their potent antifungal activity against Candida species. The mechanism of action of the echinocandins is generally thought to be the inhibition of beta-1,3-glucan synthesis, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad84b8af7cfab88eab5f89c74dcf004
https://doi.org/10.1021/jm00093a018
https://doi.org/10.1021/jm00093a018
Autor:
K Nollstadt, D C McFadden, Paul A. Liberator, M A Powles, Dennis M. Schmatz, Frances Aileen Bouffard, James F. Dropinski, J Andersen
Publikováno v:
Antimicrobial agents and chemotherapy. 39(6)
A new series of semisynthetic, water-soluble pneumocandin analogs has been found to be extremely potent against Pneumocystis carinii in an immunocompromised-rat model. These compounds are 5 to 10 times more potent than the parent natural product, pne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5129a79204cb0db0385b0eda6263781
https://pubmed.ncbi.nlm.nih.gov/7574523
https://pubmed.ncbi.nlm.nih.gov/7574523
Autor:
Suzanne M. Mandala, John R. Thompson, Myra B. Kurtz, Sarah Dreikorn, K Nollstadt, Jean A. Marrinan, Cameron M. Douglas, James M. Balkovec, Janet C. Onishi, James A. Milligan
Publikováno v:
Antimicrobial agents and chemotherapy. 38(12)
The pneumocandins are natural lipopeptide products of the echinocandin class which inhibit the synthesis of 1,3-beta-D-glucan in susceptible fungi. The lack of a corresponding pathway in mammalian hosts makes this mode of action an attractive one for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead0209db7d79004f476d907941a3f6c
https://pubmed.ncbi.nlm.nih.gov/7695257
https://pubmed.ncbi.nlm.nih.gov/7695257
Autor:
K Nollstadt, Black Regina M, Bartizal Kenneth F, M A Powles, D C McFadden, George K. Abruzzo, Dennis M. Schmatz, James M. Balkovec
Publikováno v:
The Journal of antibiotics. 45(12)
A series of lipopeptide compounds co-produced during the fermentation of pneumocandin A0 (L-671,329) and related semisynthetic compounds were evaluated in vivo against Pneumocystis carinii pneumonia and systemic candidiasis. In addition, they were te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee9ecf1fb329cf95d51995ff33c9f04
https://pubmed.ncbi.nlm.nih.gov/1490879
https://pubmed.ncbi.nlm.nih.gov/1490879
Autor:
R. Weston, E. Kaczka, August J. Kempf, Frank J. Wolf, R. E. Harman, Louis Chaiet, K. Nollstadt
Publikováno v:
Applied Microbiology. 20:421-426
A dextranase, produced by Penicillium funiculosum , was purified 1,000-fold to yield the enzyme which was demonstrated by gel electrophoresis and electrofocusing to be a homogeneous protein. The purification method included acetone partition, ammoniu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6565a3c058d3229f37fd935d099baee7
https://doi.org/10.1128/am.20.3.421-426.1970
https://doi.org/10.1128/am.20.3.421-426.1970
Publikováno v:
Progress in clinical and biological research. 238
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e034a8477eb96c494922a9236a19dca
https://pubmed.ncbi.nlm.nih.gov/3496615
https://pubmed.ncbi.nlm.nih.gov/3496615