Zobrazeno 1 - 10
of 3 589
pro vyhledávání: '"K. Niazi"'
Autor:
Kashif Bashir, PhD, Uzma K. Niazi, Raheela Shahzadi, Kaynat Azam, Asma Idrees, Qurrat U. Ain, Amin A. Alamin
Publikováno v:
Journal of Taibah University Medical Sciences, Vol 19, Iss 5, Pp 1039-1048 (2024)
الملخص: أهداف البحث: تناولت هذه الدراسة التحقيق في العلاقة بين ثلاثة متغيرات جينية: آر اس 4671393 و آر اس 1427407 و آر اس 11886868 تقع داخل جين ''بي سي ا
Externí odkaz:
https://doaj.org/article/90e3a270940d4c2e9f21411031c355a1
Publikováno v:
BioMedInformatics, Vol 4, Iss 2, Pp 1441-1456 (2024)
This article delves into the intersection of generative AI and digital twins within drug discovery, exploring their synergistic potential to revolutionize pharmaceutical research and development. Through various instances and examples, we illuminate
Externí odkaz:
https://doaj.org/article/d57e802938e942b494c0351935810ab3
Autor:
Bala Munipalli, Mohit Chauhan, Anjali M. Morris, Ridwan Ahmad, Maliha Fatima, Madeleine E. Allman, Shehzad K. Niazi, Barbara K. Bruce
Publikováno v:
Journal of Primary Care & Community Health, Vol 15 (2024)
Fibromyalgia (FM) affects 2% to 8% of the general population. FM patients often experience self-stigma and feel rejected by healthcare providers and families, resulting in isolation and distressing symptoms of pain, fatigue, and poor cognitive functi
Externí odkaz:
https://doaj.org/article/8098a7a530524266bdf4fb8ef1aa9a5e
Publikováno v:
BioMedInformatics, Vol 4, Iss 1, Pp 98-112 (2024)
The three-dimensional protein structure is pivotal in comprehending biological phenomena. It directly governs protein function and hence aids in drug discovery. The development of protein prediction algorithms, such as AlphaFold2, ESMFold, and trRose
Externí odkaz:
https://doaj.org/article/f20e0b84ab32478284c3f3117af14fb9
Autor:
Sarfaraz K. Niazi
Publikováno v:
Pharmaceuticals, Vol 17, Iss 11, p 1424 (2024)
Randomized controlled trials (RCTs) are the gold standard for testing the safety and efficacy of new drugs and biologicals. The US Food and Drug Administration (FDA) has proactively improved the trial designs to make them scientifically rational whil
Externí odkaz:
https://doaj.org/article/6a58d62fb1c9489db7e707029d7dafe6
Autor:
Sarfaraz K. Niazi, Matthias Magoola
Publikováno v:
Biologics, Vol 3, Iss 4, Pp 355-379 (2023)
Recombinant technology has been around for nearly three quarters of a century and has revolutionized protein therapy. However, the cost of developing recombinant therapeutic proteins and the manufacturing infrastructure keeps their cost unaffordable
Externí odkaz:
https://doaj.org/article/f346e5a73b1c4bf795faa2ac6bbd8f8a
Autor:
Sarfaraz K. Niazi, Matthias Magoola
Publikováno v:
Biologics, Vol 3, Iss 4, Pp 380-401 (2023)
Therapeutic proteins treat many acute and chronic diseases that were until recently considered untreatable. However, their high development cost keeps them out of reach of most patients around the world. One plausible solution to lower-cost manufactu
Externí odkaz:
https://doaj.org/article/af311884fd404045a0c42ebd42136025
Autor:
Sarfaraz K. Niazi
Publikováno v:
Encyclopedia, Vol 3, Iss 4, Pp 1345-1357 (2023)
Gene or genome editing, often known as GE, is a technique utilized to modify, eliminate, or substitute a mutated gene at the DNA level. It serves as a valuable tool in the field of genetic manipulation. Gene therapy (GT) is a therapeutic approach tha
Externí odkaz:
https://doaj.org/article/e2b225e7246949779c6e581293eeb82f
Autor:
Sarfaraz K. Niazi
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 1013 (2024)
Pharmacopeia monographs are not intended to establish biosimilarity. However, the US Food and Drug Administration (FDA) has stopped the US Pharmacopeia (USP) from creating monographs for biological drugs due to the need for side-by-side comparisons w
Externí odkaz:
https://doaj.org/article/daaa99c201a6460aa0e7ffeef0e5bb20
Autor:
Sarfaraz K. Niazi
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 918 (2024)
Drug development costs can be significantly reduced if proven “platform” technologies are allowed to be used without having to validate their use. The most recent US Food and Drug Administration (FDA) guideline brings more clarity, as well as a g
Externí odkaz:
https://doaj.org/article/c91a2325d11f4b55ab5e8001f7efdff8