Zobrazeno 1 - 10
of 37
pro vyhledávání: '"K. Nasir Khan"'
Publikováno v:
The Journal of toxicological sciences. 46(2)
The number of gene therapies in development continues to increase, as they represent a novel method to treat, and potentially cure, many diseases. Gene therapies can be conducted with an in vivo or ex vivo approach, to cause gene augmentation, gene s
Autor:
William J. Reagan, David W. Clarke, George Hu, Richard Perry, Ingrid D. Pardo, K Nasir Khan, Jennifer Colangelo, Rani S. Sellers, Victoria Markiewicz, Cynthia M. Rohde
Publikováno v:
Toxicologic Pathology. 45:416-426
Despite the use of rabbits in biomedical research, including regulatory toxicology and cardiovascular studies, little data exist on heart findings in this species. This study was designed to document myocardial findings in female rabbits and the impa
Publikováno v:
The Journal of toxicological sciences. 44(10)
Rodent in vivo carcinogenicity bioassays are required for human risk assessment and have been utilized in this capacity for decades. Accordingly, there is an abundance of data that could be accessed and analyzed to better understand the translatabili
Autor:
Zaher A. Radi, K Nasir Khan
Publikováno v:
The Journal of toxicological sciences. 44(6)
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used therapeutic class in clinical medicine. These are sub-divided based on their selectivity for inhibition of cyclooxygenase (COX) isoforms (COX-1 and COX-2) into: (1) non-sel
Publikováno v:
Journal of Immunotoxicology. 2:85-96
Results from earlier experiments in our laboratories revealed that both selective and nonselective inhibitors of cyclooxygenase-2 possess little potential for decreasing in vitro phagocytosis by rat macrophages or canine neutrophils and no potential
Autor:
B. M. Woerner, J. L. Masferrer, Demaretta S. Rush, Robert A. Soslow, Alane T. Koki, K. Nasir Khan, Andrew J. Dannenberg
Publikováno v:
Cancer. 89:2637-2645
BACKGROUND The cyclooxygenase (COX) enzyme catalyzes the formation of prostaglandins, which can affect cell proliferation and alter the response of the immune system to malignant cells. The inducible form of COX, COX-2, has been shown to be important
Autor:
K Nasir Khan, Sylvia M. Furst, John H. Mennear, Kimber L. White, Vanessa L. Peachee, Wendy J. Komocsar
Publikováno v:
Journal of immunotoxicology. 1(3)
Although both experimental and clinical literature contain reports suggestive of associations between enhanced susceptibility to soft tissue infections and nonsteroidal anti-inflammatory drug (NSAID) use, the immunotoxicological potential of this cla
Publikováno v:
Journal of immunotoxicology. 2(3)
Results from earlier experiments in our laboratories revealed that both selective and non-selective inhibitors of cyclooxygenase-2 possess little potential for decreasing in vitro phagocytosis by rat macrophages or canine neutrophils, and no potentia
Publikováno v:
Veterinary ophthalmology. 7(1)
Objective Cyclooxygenase-2 (COX-2)-derived prostaglandins (PGs) are shown to play important pathophysiologic roles in various disease states. Recently, the effectiveness of topical PGs in reducing intraocular pressure (IOP) has stimulated further int