Zobrazeno 1 - 10
of 973
pro vyhledávání: '"K. N. Houk"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Radical substitution is a useful method to functionalize heterocycles, as in the venerable Minisci reaction. Empirically observed regiochemistries indicate that the CF2H radical has a nucleophilic character similar to alkyl radicals, but the
Externí odkaz:
https://doaj.org/article/56af02b631f7408ca2251b2243d98d92
Autor:
Zexian Li, Minyan Wang, Youqing Yang, Yong Liang, Xiangyang Chen, Yue Zhao, K. N. Houk, Zhuangzhi Shi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Prized for their ability to generate chemical complexity rapidly, catalytic carbon–hydrogen (C–H) activation and functionalization reactions have enabled a paradigm shift in the standard logic of synthetic chemistry. Directing group stra
Externí odkaz:
https://doaj.org/article/644b178939ef4fd5870c2fe9079fa16a
Autor:
Sangmin Kim, Joseph W. Treacy, Yessica A. Nelson, Jordan A. M. Gonzalez, Milan Gembicky, K. N. Houk, Alexander M. Spokoyny
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Electrophilic borylation of sterically hindered arenes is a challenging transformation. Here, authors report a metal-free electrophilic C–H borylation of hindered arenes using a boron cluster reagent producing valuable aryl boronic esters.
Externí odkaz:
https://doaj.org/article/20db6fc58f9041f78d960fd9cf9b6f43
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Ligands alter the regioselectivity of Rh(I)- catalyzed cycloisomerizations of bicyclobutanes. Here, mechanistic studies performed by the authors pinpoint a concerted C−C bond cleavage and carbenoid formation responsible for the divergence.
Externí odkaz:
https://doaj.org/article/b2e7ccab14b54cda93fddef8e6875b38
Autor:
Xin Yang, Sophie Hui Min Lim, Jiachen Lin, Jie Wu, Haidi Tang, Fengyue Zhao, Fang Liu, Chenghua Sun, Xiangcheng Shi, Yulong Kuang, Joanne Yi Hui Toy, Ke Du, Yuannian Zhang, Xiang Wang, Mingtai Sun, Zhixuan Song, Tian Wang, Ji’en Wu, K. N. Houk, Dejian Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Catalysed oxidative C-C bond formation reactions are important in the synthesis of natural products, but poorly tolerated by polyphenolic flavones. Here the authors report the reactivity of molecular oxygen in alkaline water without added catalyst fo
Externí odkaz:
https://doaj.org/article/3301a34d2e2d42a28dca474d9561374a
Autor:
Lei Zhang, Chen Yang, Chenxi Lu, Xingxing Li, Yilin Guo, Jianning Zhang, Jinglong Lin, Zhizhou Li, Chuancheng Jia, Jinlong Yang, K. N. Houk, Fanyang Mo, Xuefeng Guo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Guiding chemical reactions in a predictable and controllable manner is an ultimate goal of chemistry. Here, the authors show tuning of the single-molecule Mizoroki-Heck catalytic cycle through electrical gating and direct in-situ detection.
Externí odkaz:
https://doaj.org/article/8e9e6b424dd4416eaea22045399bd582
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Pericyclase enzymes are an expanding family of enzymes. Here, the authors identify the norbornene synthase SdnG, a pericyclase for the intramolecular Diels-Alder reaction between a cyclopentadiene and an olefinic dienophile to form the sordaricin nor
Externí odkaz:
https://doaj.org/article/7d335afb622f40cc83bd744b9064bc56
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
The bridged medium-sized ring bicyclo[m.n.2] family of natural products are commonly found but difficult to synthesize efficiently. Here the authors present a cascade reaction to form the carbon skeleton, via a [3+2] cycloaddition of a captured azavi
Externí odkaz:
https://doaj.org/article/627bce7cc54a425fbd80ac8222aa7cd9
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The androgen receptor (AR) is critical in the progression of prostate cancer (PCa). Small molecule antagonists that bind to the ligand binding domain (LBD) of the AR have been successful in treating PCa. However, the structural basis by whic
Externí odkaz:
https://doaj.org/article/f6449e9ba37c4b65b086c967080fbebc
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Catalytic asymmetric dearomatization is a powerful tool for the rapid construction of diverse chiral cyclic molecules from cheap and easily available arenes. Here the authors show an organocatalytic enantioselective dearomatization of substituted thi
Externí odkaz:
https://doaj.org/article/f1b220f76da84e57b7b0847cd96eb28d