Zobrazeno 1 - 10
of 22
pro vyhledávání: '"K. Muruga Poopathi Raja"'
Autor:
Saoussen Ben Halima, Sabyashachi Mishra, K. Muruga Poopathi Raja, Michael Willem, Antonio Baici, Kai Simons, Oliver Brüstle, Philipp Koch, Christian Haass, Amedeo Caflisch, Lawrence Rajendran
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2127-2141 (2016)
Development of disease-modifying therapeutics is urgently needed for treating Alzheimer disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides produced by β- and γ-secretase-mediated cleavage of the amyloid precursor protein (APP). β
Externí odkaz:
https://doaj.org/article/6c9d943bb8c946c6b2aa849229f67a4c
Autor:
N. Arul Murugan, Chitra Jeyaraj Pandian, Jeba Mercy Jeyaseelan, S. Muneeswaran, K. Saranraj, K. Muruga Poopathi Raja, J. Jeyakanthan
Publikováno v:
Alzheimer's Disease ISBN: 9781839162305
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ad1f6aec8850fac39361544e174031b
https://doi.org/10.1039/9781839162732-00515
https://doi.org/10.1039/9781839162732-00515
Publikováno v:
Advances in experimental medicine and biology. 1322
Three types of chemical entities, namely, small organic molecules (organics), peptides, and biologics, are mainly used as drug candidates for the treatment of various diseases. Even though the peptide drugs are known since 1920 in association with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8bfdee510d0bb243a7dc1c9f7be05e31
https://pubmed.ncbi.nlm.nih.gov/34258744
https://pubmed.ncbi.nlm.nih.gov/34258744
Publikováno v:
Antiviral Drug Discovery and Development ISBN: 9789811602665
Three types of chemical entities, namely, small organic molecules (organics), peptides, and biologics, are mainly used as drug candidates for the treatment of various diseases. Even though the peptide drugs are known since 1920 in association with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::150edf1ca7ca1f04bda617cafbd06ef3
https://doi.org/10.1007/978-981-16-0267-2_10
https://doi.org/10.1007/978-981-16-0267-2_10
Publikováno v:
Chemistry - A European Journal. 23:16644-16652
The most important natural α- and 310 -helices are stabilized by unidirectional intramolecular hydrogen bonds along the helical cylinder. In contrast, we report here on 12/10-helical conformations with alternately changing hydrogen-bond directionali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0eada6fda8dda5f712f12122f418278
https://doi.org/10.1002/chem.201703871
https://doi.org/10.1002/chem.201703871
Autor:
Michael Willem, Sabyashachi Mishra, Amedeo Caflisch, Lawrence Rajendran, Philipp Koch, Kai Simons, Christian Haass, Antonio Baici, Oliver Brüstle, Saoussen Ben Halima, K. Muruga Poopathi Raja
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2127-2141 (2016)
Cell reports 14(9), 2127-2141 (2016). doi:10.1016/j.celrep.2016.01.076
Cell Reports
Cell reports 14(9), 2127-2141 (2016). doi:10.1016/j.celrep.2016.01.076
Cell Reports
SummaryDevelopment of disease-modifying therapeutics is urgently needed for treating Alzheimer disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides produced by β- and γ-secretase-mediated cleavage of the amyloid precursor protein (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb3e28d2c3a9a75894ba5236b4ddb35
http://www.sciencedirect.com/science/article/pii/S2211124716300754
http://www.sciencedirect.com/science/article/pii/S2211124716300754
Autor:
Rajkumar Misra, K. Muruga Poopathi Raja, Hans-Joerg Hofmann, Hosahudya N. Gopi, Gijo George, Kuruva Veeresh, Abhijith Saseendran, Srinivasarao Raghothama
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 23(15)
Here, novel 12-helices in α,γ-hybrid peptides composed of achiral α-aminoisobutyric acid (Aib) and 4-aminoisocaproic acid (Aic, doubly homologated Aib) monomers in 1:1 alternation are reported. The 12-helices were indicated by solution and crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5d9553d06e7bbf6bb10b840d2f8385
https://pubmed.ncbi.nlm.nih.gov/28052426
https://pubmed.ncbi.nlm.nih.gov/28052426
Publikováno v:
Chemical Communications. 51:13397-13399
Utilization of conjugated double bonds to engineer the novel folded miniature β-meander type structures, single step transformation of miniature β-meanders into ααγ(4)-hybrid peptide 10/12-helices using catalytic hydrogenation, their solution an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72cf42ee9b400a46223b2865bab56ce3
https://doi.org/10.1039/c5cc04523a
https://doi.org/10.1039/c5cc04523a
Autor:
Kuruva Veeresh, Mona M. Katariya, Varsha J. Thombare, Mothukuri Ganesh Kumar, Hosahudya N. Gopi, K. Muruga Poopathi Raja
Publikováno v:
Angewandte Chemie (International ed. in English). 55(27)
The impact of geometrically constrained cis α,β-unsaturated γ-amino acids on the folding of α,γ-hybrid peptides was investigated. Structure analysis in single crystals and in solution revealed that the cis carbon-carbon double bonds can be accom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266d11da741af0a0ad2e7260fe6f9064
https://pubmed.ncbi.nlm.nih.gov/27271202
https://pubmed.ncbi.nlm.nih.gov/27271202
Autor:
K. Muruga Poopathi Raja, Padmanabhan Balaram, Subrayashastry Aravinda, Anindita Sengupta, Narayanaswamy Shamala
Publikováno v:
Org. Biomol. Chem.. 4:4214-4222
The crystal structures of five model peptides Piv-Pro-Gly-NHMe (1), Piv-Pro-βGly-NHMe (2), Piv-Pro-βGly-OMe (3), Piv-Pro-δAva-OMe (4) and Boc-Pro-γAbu-OH (5) are described (Piv: pivaloyl; NHMe: N-methylamide; βGly: β-glycine; OMe: O-methyl este
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46a3db1f237c57a9961ad85d3cfa95ae
https://doi.org/10.1039/b609863k
https://doi.org/10.1039/b609863k