Zobrazeno 1 - 10
of 194
pro vyhledávání: '"K. Medzihradszky"'
Autor:
K. Medzihradszky
Publikováno v:
Journal of Peptide Science. 9:333-353
Since the discovery of the opioid receptors and their endogenous ligands an immense research work has been devoted to the exploration of their specificity, the mechanism of ligand binding and ligand–receptor interactions. One of the main goals has
Publikováno v:
Biochemical and Biophysical Research Communications. 265:513-519
Opioid binding properties of Tyr-D-Ser-Gly-Phe-Leu-Thr-NH-NH-Gly-Mal (DSLET-Mal), a novel enkephalin-framed affinity label, was determined in rat brain membranes. In competition studies the ligand showed high affinity for the delta opioid sites, labe
Autor:
Sándor Benyhe, András Z. Rónai, K. Medzihradszky, Ildikó Szatmári, György Orosz, Nana Sartania, Anna Borsodi
Publikováno v:
European Journal of Pharmacology. 373:241-249
[Met5]enkephalin-Arg-Phe (Tyr-Gly-Gly-Phe-Met-Arg-Phe) was modified with the methyl esther of melphalan (Mel; 4-bis(2-chloroethyl)amino-L-phenylalanine) and the resulting compounds were studied for their opioid binding properties in guinea pig and ra
Publikováno v:
Biochemical and Biophysical Research Communications. 202:1285-1290
Opioid receptor antagonist properties of the μ opioid receptor selective peptide, BOC-Tyr-Lys-Lys-trp-Trp-NH 2 and its systematically modified analogues were determined in guinea pig ileum, mouse vas deferens and rabbit vas deferens bioassays to loc
Autor:
K. Medzihradszky, A.Z. Rónai, András Perczel, Sándor Holly, Anna Magyar, Zs. Majer, Gerald D. Fasman, Miklós Hollósi
Publikováno v:
Biopolymers. 34:177-185
Comparative CD and Fourier transform ir (FTIR) spectroscopic data on N-Boc protected linear peptides with or without the (Pro-Gly) beta-turn motif (e.g., Boc-Tyr-Pro-Gly-Phe-Leu-OH and Boc-Tyr-Gly-Pro-Phe-Leu-OH) are reported herein. The CD spectra,
Publikováno v:
Pharmacology. 49:121-131
To find a delta-opioid receptor preferring peptide structure containing an Asp residue in a potentially interacting position, Tyr-Pro-Phe-Asp, Tyr-D-Ala-Phe-Asp, Tyr-D-Ala-Gly-Phe-Asp, Tyr-D-Ala-Gly-Phe-Asp alpha- and beta-methyl ester and Tyr-Gly-Gl
Autor:
K. Medzihradszky
Publikováno v:
ChemInform. 25
Publikováno v:
Neuropeptides. 17:111-116
A series of alpha-gliadin fragments, structurally related to alpha-gliadin-(43-49), were synthesized. The effect of these fragments and beta-casomorphin and naloxone on the steady-state binding of [125I]-alpha-gliadin-(43-49) to human peripheral bloo
Publikováno v:
Journal of Neuroscience Research. 25:549-555
A kappa-opioid receptor subtype was purified from a digitonin extract of frog brain membranes, using affinity chromatography. The affinity resin was prepared by coupling dynorphin (1-10) to AH Sepharose 4B. The purified receptor binds 4,750 pmol [3H]
Publikováno v:
Neuropeptides. 31(1)
It has been previously found that chloromethyl ketone derivatives of enkephalins bind irreversibly to the opioid receptors in vitro. Recently a novel affinity reagent, Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Gly chloromethyl ketone (Dynorphin(1-10)-G