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Akademický článek

Fungal and Bacterial Loads: Noninvasive Inflammatory Bowel Disease Biomarkers for the Clinical Setting

Autor: G. Sarrabayrouse, A. Elias, F. Yáñez, L. Mayorga, E. Varela, C. Bartoli, F. Casellas, N. Borruel, C. Herrera de Guise, K. Machiels, S. Vermeire, C. Manichanh

Publikováno v: mSystems, Vol 6, Iss 2 (2021)

ABSTRACT Microbiome sequence data have been used to characterize Crohn's disease (CD) and ulcerative colitis (UC). Based on these data, we have previously identified microbiomarkers at the genus level to predict CD and CD relapse. However, microbial

Externí odkaz: https://doaj.org/article/2974d625b5e24216b1cba5690fe2589e

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OP01 Sequencing-based gene network analysis reveals a profound role for ferroptosis key gene GPX4 in post-operative endoscopic recurrence in Crohn’s disease

Autor: S Verstockt, K Machiels, J Dehairs, K Rems, I De Greef, D Jans, J Sabino, M Ferrante, S Vermeire, B Verstockt

Publikováno v: Journal of Crohn's and Colitis. 17:i1-i3

Background An ileocolonic resection with ileocolonic anastomosis is often required in patients with Crohn’s disease (CD). Postoperative recurrence (POR) is common, with host-luminal interactions being implicated. However, these interactions are poo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07edc5d74cf496ccfb803d7eef209051
https://doi.org/10.1093/ecco-jcc/jjac190.0001

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P921 FMT in UC is associated with a decrease in Bacteroides-2 enterotype and response with baseline RNA and microbiota signatures

Publikováno v: Journal of Crohn's and Colitis. 17:i1029-i1031

Background The efficacy of faecal microbiota transplantation (FMT) in UC has been reported to be donor-, patient- and procedure-dependent (Rees et al., 2022). The RESTORE-UC trial [NCT03110289] aimed to improve the outcome of FMT in patients with act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c71fb560ccafd86d76289d5f781d142
https://doi.org/10.1093/ecco-jcc/jjac190.1051

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P095 Anti-inflammatory effect of high acetate concentration on organoid-derived epithelial monolayer from patients with Ulcerative Colitis

Autor: S Deleu, K Arnauts, K Machiels, G R B Huys, J Thevelein, J Raes, S Vermeire

Publikováno v: Journal of Crohn's and Colitis. 16:i192-i195

Background Short-chain fatty acids (SCFA), such as acetate and butyrate, have gained increasing interest for their potential to suppress IBD inflammation1,4. Most data have been generated for butyrate, showing beneficial effects on the gut microbiome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::243660e44a25cafef87b8f7c0b6c4309
https://doi.org/10.1093/ecco-jcc/jjab232.224

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DOP53 Community types of the human gut virome are associated with endoscopic outcome in UC patients

Autor: D Jansen, G Falony, S Vieira-Silva, C Simsek, T Marcelis, K Machiels, C Caenepeel, J Raes, V Severine, J Matthijnssens

Publikováno v: Journal of Crohn's and Colitis. 17:i124-i124

Background Inflammatory bowel diseases (IBD) are a group of chronic inflammatory diseases of the gut. The pathophysiology is unknown; however, it is thought to result from an inappropriate immune reaction to the commensal gut microbiota. Community-ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7666cf9aa7be7053cf93a8826f207729
https://doi.org/10.1093/ecco-jcc/jjac190.0093

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OP03 Standardized faecal microbiota transplantation with microbiome-guided donor selection in active UC patients: A randomized, placebo-controlled intervention study

Autor: C Caenepeel, S Deleu, K Arnauts, J F Vazquez Castellanos, S Braekeleire, K Machiels, F Baert, F Mana, L Pouillon, P Hindryckx, T Lobaton, E Louis, D Franchimont, M Ferrante, J Sabino, S Vieira-Silva, G Falony, J Raes, S Vermeire

Publikováno v: Journal of Crohn's and Colitis. 16:i003-i004

Background Four randomized controlled trials studying faecal microbiota transplantation (FMT) in active UC patients showed variable success rates. The efficacy of FMT appears to be influenced by various factors including donor- and procedure-specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4294b5d9fbe66e5fb78284d894eec2cd
https://doi.org/10.1093/ecco-jcc/jjab232.002

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