Zobrazeno 1 - 10
of 16
pro vyhledávání: '"K. M. WELSH"'
Autor:
Dzuy T. Nguyen, Eleanor F. Howland, S. M. Herrmann, C. A. Morse, Russell J. Bacquet, Jones Terence R, Ward W. Smith, Charlotte A. Bartlett, Stephanie Webber, K. M. Welsh, Cheryl Ann Janson, Kathardekar, M. R. Reddy, Carol L. J. Booth, H. Mazdiyasni, Lewis Kk, J. White, A. Johnston, J. Deal, Stephen E. Webber, David A. Matthews, Robert William Ward, Varney
Publikováno v:
Journal of Medicinal Chemistry. 40:677-683
Six new diphenyl sulfoxide and five new diphenyl sulfones were designed, synthesized, and tested for their inhibition of human and Escherichia coli thymidylate synthase (TS) and of the growth of cells in tissue culture. The best sulfoxide inhibitor o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b00058c01b30433c8d4b3576dc6989
https://doi.org/10.1021/jm960613f
https://doi.org/10.1021/jm960613f
Autor:
Eleanor F. Howland, S. H. Reich, J. White, Varney Michael D, Marzoni Gifford P, S. M. Herrmann, C. A. Morse, Robert William Ward, Carol L. J. Booth, K. M. Welsh, Nguyen Dzuy Nguyen Dzuy, Charlotte A. Bartlett, Stephanie Webber
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d99c365643afe3712636b0bce672a42
https://doi.org/10.1002/chin.199303159
https://doi.org/10.1002/chin.199303159
Autor:
T. R. JONES, M. D. VARNEY, S. E. WEBBER, K. K. LEWIS, G. P. MARZONI, C. L. PALMER, V. KATHARDEKAR, K. M. WELSH, S. WEBBER, D. A. MATTHEWS, K. APPELT, W. W. SMITH, C. A. JANSON, J. E. VILLAFRANCA, R. J. BACQUET, E. F. HOWLAND, C. L. J. BOOTH, S. M. HERRMANN, R. W. WARD, J. WHITE, ET AL. ET AL.
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5d02a888bfb3ca3984090ddf61d00c6
https://doi.org/10.1002/chin.199623165
https://doi.org/10.1002/chin.199623165
Autor:
K. K. Lewis, Varney Michael D, V. Kathardekar, Stephen E. Webber, W. W. Smith, J. Deal, K. M. Welsh, Eleanor F. Howland, A L A L Et Et, Cheryl Ann Janson, S. M. Herrmann, Robert William Ward, M. R. Reddy, Jones Terence R, H. Mazdiyasni, A. Johnston, Nguyen Dzuy Nguyen Dzuy, David A. Matthews, Carol L. J. Booth, R. J. Bacquet, J. M. White, Stephanie Webber
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::201e17e042b9b510146812a0e89ce63a
https://doi.org/10.1002/chin.199724103
https://doi.org/10.1002/chin.199724103
Publikováno v:
Scopus-Elsevier
Escherichia coli MutH possesses an extremely weak d(GATC) endonuclease that responds to the state of methylation of the sequence (Welsh, K. M., Lu, A.-L., Clark, S., and Modrich, P. (1987) J. Biol. Chem. 262, 15624-15629). MutH endonuclease is activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd02b1663a30d859ff251636c565989
https://doi.org/10.1016/s0021-9258(19)49816-5
https://doi.org/10.1016/s0021-9258(19)49816-5
Publikováno v:
Pediatric nursing. 25(1)
Asthma is a leading cause of admission to the pediatric inpatient setting. Despite advances in the treatment of this chronic condition, morbidity and mortality continue to increase. It is also a source of significant variation in clinical practice an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::321b985f23d2911a707c0a52cc9d5446
https://pubmed.ncbi.nlm.nih.gov/10335254
https://pubmed.ncbi.nlm.nih.gov/10335254
Publikováno v:
Journal of bacteriology. 176(23)
An essential guanine nucleotide-binding protein, Obg, of Bacillus subtilis has been characterized with respect to its enzymatic activity for GTP. The protein was seen to hydrolyze GTP with a Km of 5.4 microM and a kcat of 0.0061 min-1 at 37 degrees C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e34e53d0b2b900cb61ab2e88ae12134
https://pubmed.ncbi.nlm.nih.gov/7961487
https://pubmed.ncbi.nlm.nih.gov/7961487
Autor:
S E, Webber, T M, Bleckman, J, Attard, J G, Deal, V, Kathardekar, K M, Welsh, S, Webber, C A, Janson, D A, Matthews, W W, Smith
Publikováno v:
Journal of medicinal chemistry. 36(6)
The design, synthesis, and biological evaluation of a new class of inhibitors of thymidylate synthase (TS) is described. The molecular design was carried out by a repetitive crystallographic analysis of protein-ligand structures. At the onset of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb4c3faed0494f1627d0ddf111d1c68
https://pubmed.ncbi.nlm.nih.gov/8459400
https://pubmed.ncbi.nlm.nih.gov/8459400
Publikováno v:
Journal of Biological Chemistry. 254:9254-9261
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eae01965ceee0edee37060373e32e892
https://doi.org/10.1016/s0021-9258(19)86838-2
https://doi.org/10.1016/s0021-9258(19)86838-2
Publikováno v:
Scopus-Elsevier
The Escherichia coli mutL gene product has been purified to near homogeneity from an overproducing clone. The mutL locus encodes a polypeptide of 70,000 daltons as determined by denaturing gel electrophoresis. The native molecular weight of MutL prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54c4ca7e9a265fda9de026128f77e1a
https://doi.org/10.1016/s0021-9258(19)85043-3
https://doi.org/10.1016/s0021-9258(19)85043-3