Zobrazeno 1 - 9
of 9
pro vyhledávání: '"K. M. O'Shaughnessy"'
Publikováno v:
Heart (British Cardiac Society). 91(12)
The β-1 adrenoceptor (AR), and to a lesser extent the β-2 AR, mediate the effect of circulating catecholamines on the pumping efficiency of the heart through positive inotropic, chronotropic, and lusitropic effects. These responses are required to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e4dbd68b440bb24307b6522d5100d3
https://pubmed.ncbi.nlm.nih.gov/16287753
https://pubmed.ncbi.nlm.nih.gov/16287753
Autor:
K. M. O’Shaughnessy, M. R. Wilkins
Publikováno v:
Cardiovascular Pharmacogenetics ISBN: 9783642072918
Hypertension is an asymptomatic condition but a major risk factor for cardiovascular events and stroke. Blood pressure exhibits a skewed normal distribution in the general population with no natural hypertensive threshold. Decisions regarding who to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c509d359c91aa3eaad11be161f51479
https://doi.org/10.1007/978-3-662-06214-2_6
https://doi.org/10.1007/978-3-662-06214-2_6
Publikováno v:
British journal of pharmacology. 138(2)
1. We studied the biochemical and contractile responses of isolated human myocardial tissue expressing native receptor variants of the 389GR beta(1)-adrenoceptor polymorphism. 2. Right atrial appendage was obtained from homozygous RR patients (n=37)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d9770a6f32b264dfc0e34ce76c4d09b8
https://pubmed.ncbi.nlm.nih.gov/12540516
https://pubmed.ncbi.nlm.nih.gov/12540516
Publikováno v:
Clinical science (London, England : 1979). 99(3)
Mutation scanning of the beta1-adrenoceptor gene has identified a polymorphism, G389R, that markedly affects G-protein coupling of the receptor and resulting cAMP production. We have investigated the effect of this functionally active polymorphism on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5dbb3a2293ad2c8a3d32d40703d7f380
https://pubmed.ncbi.nlm.nih.gov/11787476
https://pubmed.ncbi.nlm.nih.gov/11787476
Publikováno v:
Journal of Human Hypertension. 28:342-342
Correction to: Journal of Human Hypertension (2013) 27, 635–655; doi:10.1038/jhh.2013.72 Since the publication of the above paper, the authors have amended the title of this paper to: ‘PD.1. MO25β has no physiological role in electrolyte homeost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb72dad26269b7e996a3070ced91734e
https://doi.org/10.1038/jhh.2013.120
https://doi.org/10.1038/jhh.2013.120
Publikováno v:
Postgraduate medical journal. 77(912)
As a cause for hypertension, aldosterone excess is now thought to be more prevalent than previously quoted in textbooks. Classical features of hypokalaemia and metabolic alkalosis can be absent even in the presence of marked hypertension. This implie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01907f11ac2d9f19a0c23a169748da2
https://pubmed.ncbi.nlm.nih.gov/11571370
https://pubmed.ncbi.nlm.nih.gov/11571370
Autor:
C T, Hu, K M, O'Shaughnessy
Publikováno v:
Electrophoresis. 22(6)
Representational difference analysis (RDA) is a widely used technique in molecular biology. However, in practice, its efficiency depends on a rapid and reliable separation of the RDA fragments prior to cloning. To achieve this, we have compared and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ad7380b879e644c98d7f9d3c72d99c9
https://pubmed.ncbi.nlm.nih.gov/11358126
https://pubmed.ncbi.nlm.nih.gov/11358126
A 64 year old woman presented with loss of appetite, weight loss, and altered bowel habit. A barium enema confirmed the presence of a caecal carcinoma. A liver ultrasound scan was normal and admission for a right hemicolectomy was planned. Three days
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f43d3875130f990487e4fe1cae9ece0
https://europepmc.org/articles/PMC1741652/
https://europepmc.org/articles/PMC1741652/
Publikováno v:
Psychopharmacology. 89:414-420
This study has investigated the influence of central noradrenergic function on 5-HT2-mediated head-twitch responses in mice. Central injection of low doses of the alpha 1-adrenoceptor agonists phenylephrine or methoxamine, or peripheral administratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760eb962a41e890c53f821cdfd782028
https://doi.org/10.1007/bf02412113
https://doi.org/10.1007/bf02412113