Zobrazeno 1 - 10
of 11
pro vyhledávání: '"K. M. K. Bottomley"'
Autor:
P.J. Malsher, Michael J. Broadhurst, K. M. K. Bottomley, Geoffrey Lawton, Brown Paul Anthony, M.I. Cooper, J. S. Nixon, Ian Reginald Kilford, Neera Borkakoti, William Henry Johnson, N. Ballantyne, A.J. Eatherton, B.M. Sutton, E. J. Lewis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2299-2302
A novel series of MMP inhibitors has been identified. The compounds are potent selective inhibitors of collagenase with good solubility and oral bioavailability. One compound, designated Ro32-3555, has been selected for development as a cartilage pro
Autor:
J. Bishop, M. Brewster, J. M. Budd, David Bradshaw, F. Rose, Brown Paul Anthony, William Henry Johnson, K. M. K. Bottomley, Michael J. Broadhurst, K. Wilson, J. S. Nixon, B.M. Sutton, A. Greenham, L H Elliott, E. J. Lewis
Publikováno v:
British Journal of Pharmacology. 121:540-546
1. Ro 32-3555 (3(R)-(cyclopentylmethyl)-2(R)-[(3,4,4-trimethyl-2,5-dioxo-1- imidazolidinyl)methyl]-4-oxo-4-piperidinobutyrohydroxamic acid) is a potent, competitive inhibitor of human collagenases 1, 2 and 3 (Ki values of 3.0, 4.4 and 3.4 nM, respect
Autor:
Hans Werner Lahm, Pat Eyers, Brown Paul Anthony, Michael J. Broadhurst, L H Elliott, John M. Budd, Trevor J. Hallam, Urs Röthlisberger, David Bradshaw, Geoffrey Lawton, Amanda Whittle, J. S. Nixon, Maisie James, Hill Christopher Huw, Janet E. Merritt, Neera Borkakoti, William Henry Johnson, Balraj Krishnan Handa, K. M. K. Bottomley
Publikováno v:
Biochemical Journal. 323:483-488
N-terminal analysis of aggrecan fragments lost from bovine nasal cartilage cultured in the presence of recombinant human interleukin 1alpha revealed a predominant ARGSVIL sequence with an additional ADLEX sequence. Production of the ARGSVIL-containin
Publikováno v:
Metalloproteinases as Targets for Anti-Inflammatory Drugs
Structural characteristics of the matrix metalloproteinases.- Matrix metalloproteinase inhibitors.- Role of stromelysin-1 in cartilage metabolism.- Matrix metalloproteinases in neuro-inflammatory disease.- Membrane type matrix metalloproteinases: Reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb2410709b47b8e149f7c341be12e47d
https://doi.org/10.1007/978-3-0348-8666-6
https://doi.org/10.1007/978-3-0348-8666-6
Autor:
A. D’Arcy, John S. Nixon, D. Bradshaw, E. J. Murray, Neera Borkakoti, Hill Christopher Huw, David Williams, F. K. Winkler, Paul Anthony Brown, Michael J. Broadhurst, Lawton Geoffrey, K. M. K. Bottomley, William Henry Johnson, E. J. Lewis
Publikováno v:
Structure-Based Drug Design ISBN: 9789048150786
Collagenase belongs to a family of zinc and calcium dependent enzymes, the matrix metalloproteinases (MMPs), which are synthesised as zymogens in connective tissue (1, 2). The MMPs, also called matrixins, represent viable targets for drug design sinc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c4e716336a981a0f2f6e815c2654a04
https://doi.org/10.1007/978-94-015-9028-0_7
https://doi.org/10.1007/978-94-015-9028-0_7
Autor:
M. C. Meikle, J P O'Connell, K. M. K. Bottomley, J R Morphy, Andrew J. P. Docherty, John J. Reynolds, Peter Hill
Two low-molecular-mass inhibitors of matrix metalloproteinases (MMPs), CT1166, a concentration-dependent selective inhibitor of gelatinases A and B, and Ro 31-7467, a concentration-dependent selective inhibitor of collagenase, were examined for their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157390195dadeba6b588e72537f64346
https://europepmc.org/articles/PMC1136859/
https://europepmc.org/articles/PMC1136859/
Publikováno v:
Agents and Actions. 14:475-477
Guinea-pigs were sensitized either by i.p. administration or by a novel procedure involving inhalation of ovalbumin (2, 0.2 and 0.002%) on days 0, 5 and 19 respectively. Lung strips from these guinea-pigs were challenged with both low (0.02 microgram
Publikováno v:
The Journal of pharmacy and pharmacology. 40(3)
The incorporation of 35SO4 into cartilage proteoglycan has been employed as a measure of patella damage in the murine antigen-induced arthritis model. In a preliminary set of experiments, where both the proteoglycan concentration and 35SO4 incorporat
Publikováno v:
British journal of pharmacology. 93(3)
1. Employing rat femoral head cartilage implanted in a 6 day old mouse air pouch, the effects of inflammatory stimuli (i.e. cotton pellets, carrageenan, zymosan) on the loss of proteoglycan and collagen and granuloma formation have been studied. 2. W
Publikováno v:
Journal of Pharmacy and Pharmacology. 40:227-228
Levels of the acute phase reactant serum amyloid P (SAP) have been measured in the mouse pouch model of rheumatoid arthritis. Implantation of cartilage resulted in a significant and rapid elevation in the SAP concentration, which remained high for th