Výsledky vyhledávání - "K. M. Connors"

Sponge-Gel-Supported Histoculture Drug-Response Assay for Head and Neck Cancer: Correlations With Clinical Response to Cisplatin

Autor: K. M. Connors, Robert M. Hoffman, Anna Maria Storniolo, C. Hanchett, K. T. Robbins

Publikováno v: Archives of Otolaryngology - Head and Neck Surgery. 120:288-292

Objective: Sponge-gel–supported histoculture drug-response assay (SSHDRA) represents a promising method to determine chemosensitivity of solid tumors. To determine whether the assay correlates clinically, we compared the in vivo and in vitro effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451656974f315b49c117671ff90d6624
https://doi.org/10.1001/archotol.1994.01880270036007

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Lack of influence of c-Ha-ras expression on the drug sensitivity of human bladder cancer histocultured in three-dimensions

Autor: D, Theodorescu, K M, Connors, A, Groce, R M, Hoffman, R S, Kerbel

Publikováno v: Anticancer research. 13(4)

The mechanism of drug resistance in human cancers is complex. In addition to overexpression of a series of multiple-drug-resistance genes, there has been the suggestion that the Ha-ras gene may participate in conferring resistance. In this study, a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d6af69b10efd9fb9a24b73fbba4f62c6
https://pubmed.ncbi.nlm.nih.gov/8352563

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Correlation of drug response in human tumors histocultured in vitro with an image-analysis MTT end point and in vivo xenografted in nude mice

Autor: D, Colangelo, H Y, Guo, K M, Connors, T, Kubota, L, Silvestro, R M, Hoffman

Publikováno v: Anticancer research. 12(5)

We have in this study used the 3-(4,5-dimethyl-2- thiazoyl) -2,5-diphenyl 2-H-tetrazolium bromide (MTT) end point in our histoculture drug-response assay. We have previously demonstrated that the formazan crystals formed by MTT reduction by mitochond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a02a9cb3c5f064af6cb995fa428ed4f
https://pubmed.ncbi.nlm.nih.gov/1444193

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In vitro histoculture of human tumors with fluorescent dye end-points measured by confocal microscopy: high correlation of in vitro and in vivo chemosensitivity

Autor: H Y, Guo, D, Colangelo, L, Li, K M, Connors, T, Kubota, R M, Hoffman

Publikováno v: Anticancer research. 12(4)

Tumors from 40 patients and 7 established human xenograft tumor lines were grown in three-dimensional histoculture. A Viable-Cell-Index (VCI) based on fluorescent dyes and Growth Fraction Index (GFI) based on [3H]thymidine incorporation were measured

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::44564d49366f44df778c627835c4b91c
https://pubmed.ncbi.nlm.nih.gov/1323946

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The distinction of small cell and non-small cell lung cancer by growth in native-state histoculture

Autor: R A, Vescio, K M, Connors, G M, Bordin, J A, Robb, T, Youngkin, J N, Umbreit, R M, Hoffman

Publikováno v: Cancer research. 50(18)

Histological analysis remains the primary method of distinguishing between small cell (SCLC) and non-small cell lung cancer (NSCLC). This distinction has significant impact therapeutically because of their relative difference in chemoresponsiveness (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f581858c929e9f144c2af195172a02a
https://pubmed.ncbi.nlm.nih.gov/2168289

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