Zobrazeno 1 - 10
of 20
pro vyhledávání: '"K. Lockhart Jamieson"'
Autor:
Hao Zhang, K. Lockhart Jamieson, Justin Grenier, Anish Nikhanj, Zeyu Tang, Faqi Wang, Shaohua Wang, Jonathan G. Seidman, Christine E. Seidman, Richard Thompson, John M. Seubert, Gavin Y. Oudit
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 11 (2022)
Background Myocardial iron deficiency (MID) in heart failure (HF) remains largely unexplored. We aim to establish defining criterion for MID, evaluate its pathophysiological role, and evaluate the applicability of monitoring it non‐invasively in hu
Externí odkaz:
https://doaj.org/article/c23e0a1b258047ce88cef7083fc5215d
Autor:
Deanna K. Sosnowski, K. Lockhart Jamieson, Ahmed M. Darwesh, Hao Zhang, Hedieh Keshavarz-Bahaghighat, Robert Valencia, Anissa Viveiros, Matthew L. Edin, Darryl C. Zeldin, Gavin Y. Oudit, John M. Seubert
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
ObjectiveMetabolites derived from N−3 and N−6 polyunsaturated fatty acids (PUFAs) have both beneficial and detrimental effects on the heart. However, contribution of these lipid mediators to dilated cardiomyopathy (DCM)-associated mitochondrial d
Externí odkaz:
https://doaj.org/article/61ddb9d2de3445089431a52f40b77b22
Autor:
K. Lockhart Jamieson, Hedieh Keshavarz-Bahaghighat, Ahmed M. Darwesh, Deanna K. Sosnowski, John M. Seubert
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Biological aging is an inevitable part of life that has intrigued individuals for millennia. The progressive decline in biological systems impacts cardiac function and increases vulnerability to stress contributing to morbidity and mortality in aged
Externí odkaz:
https://doaj.org/article/5a64da53b36c44f9a30c69bc574d8016
Autor:
Victor Samokhvalov, K. Lockhart Jamieson, Ahmed M. Darwesh, Hedieh Keshavarz-Bahaghighat, Tim Y. T. Lee, Matthew Edin, Fred Lih, Darryl C. Zeldin, John M. Seubert
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2019)
Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity. Linoleic acid (18:2n6, LA) is an essential n-6 PUFA which is converted to arachidonic aci
Externí odkaz:
https://doaj.org/article/2414df085bd2474db0fdc6e2124d044d
Autor:
Deanna K. Sosnowski, K. Lockhart Jamieson, Artiom Gruzdev, Yingxi Li, Robert Valencia, Ala Yousef, Zamaneh Kassiri, Darryl C. Zeldin, John M. Seubert
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H670-H687
Endotoxemia elicits a multiorgan inflammatory response that results in cardiac dysfunction and often leads to death. Inflammation-induced metabolism of endogenous N-3 and N-6 polyunsaturated fatty acids generates numerous lipid mediators, such as epo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da665ab88e4b36717deafd25add253c
https://doi.org/10.1152/ajpheart.00217.2022
https://doi.org/10.1152/ajpheart.00217.2022
Autor:
Keshav Gopal, Abdualrahman Mohammed Abdualkader, Xiaobei Li, Amanda A. Greenwell, Qutuba G. Karwi, Christina Saed, Golam M. Uddin, Ahmed M. Darwesh, K Lockhart Jamieson, Tariq R. Altamimi, Ryekjang Kim, Farah Eaton, John M. Seubert, Gary D. Lopaschuk, John R. Ussher, Rami Al Batran
SUMMARYPyruvate dehydrogenase (PDH) is the rate-limiting enzyme for glucose oxidation that links glycolysis-derived pyruvate with the TCA cycle. Although skeletal muscle is a significant site for glucose oxidation and is closely linked with metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8354c8ea7210625299ebc48cd417067a
https://doi.org/10.1101/2023.05.10.540277
https://doi.org/10.1101/2023.05.10.540277
Autor:
Loryn J. Bohne, Hailey J. Jansen, Tristan W. Dorey, Irene M. Daniel, K. Lockhart Jamieson, Darrell D. Belke, Megan D. McRae, Robert A. Rose
Publikováno v:
JACC: Basic to Translational Science.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80418a540981d35903a7c96190ae1897
https://doi.org/10.1016/j.jacbts.2023.01.005
https://doi.org/10.1016/j.jacbts.2023.01.005
Autor:
Hailey J. Jansen, Motahareh Moghtadaei, K. Lockhart Jamieson, Robert A. Rose, Tristan W. Dorey
Publikováno v:
Heart Rhythm. 18:1999-2008
Background Heart rate variability (HRV) is determined by intrinsic sinoatrial node (SAN) activity and the autonomic nervous system (ANS). HRV is reduced in aging; however, aging is heterogeneous. Frailty, which can be measured using a frailty index (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f34f795831b9f2cb2643dddffac19e
https://doi.org/10.1016/j.hrthm.2021.07.069
https://doi.org/10.1016/j.hrthm.2021.07.069
Autor:
Robert A. Rose, K. Lockhart Jamieson
Publikováno v:
Heart Rhythm. 19:125-126
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fb3c01e78d46a93e8cd3d7aab0ded22
https://doi.org/10.1016/j.hrthm.2021.10.002
https://doi.org/10.1016/j.hrthm.2021.10.002
Autor:
Gavin Y. Oudit, Deanna K Sosnowski, Saumya Shah, Darryl C. Zeldin, Bruce D. Hammock, John M. Seubert, Zamaneh Kassiri, Hao Zhang, Matthew L. Edin, Jun Yang, Pavel Zhabyeyev, Ahmed M. Darwesh, K. Lockhart Jamieson
Publikováno v:
International Journal of Molecular Sciences
International journal of molecular sciences, vol 22, iss 4
International Journal of Molecular Sciences, Vol 22, Iss 1691, p 1691 (2021)
Volume 22
Issue 4
International journal of molecular sciences, vol 22, iss 4
International Journal of Molecular Sciences, Vol 22, Iss 1691, p 1691 (2021)
Volume 22
Issue 4
Myocardial infarction (MI) accounts for a significant proportion of death and morbidity in aged individuals. The risk for MI in females increases as they enter the peri-menopausal period, generally occurring in middle-age. Cytochrome (CYP) 450 metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea161172a20c6c0a7732c24913d41765
http://europepmc.org/articles/PMC7915306
http://europepmc.org/articles/PMC7915306