Zobrazeno 1 - 10
of 378
pro vyhledávání: '"K. Lerch"'
Autor:
Brian J Paleo, Kathryn M Madalena, Rohan Mital, Kevin E McElhanon, Thomas A Kwiatkowski, Aubrey L Rose, Jessica K Lerch, Noah Weisleder
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231194 (2020)
Various injuries to the neural tissues can cause irreversible damage to multiple functions of the nervous system ranging from motor control to cognitive function. The limited treatment options available for patients have led to extensive interest in
Externí odkaz:
https://doaj.org/article/c29e3ca517324b0ab49c948ce8e8fd76
Autor:
Vikram Shettigar, Bo Zhang, Sean C. Little, Hussam E. Salhi, Brian J. Hansen, Ning Li, Jianchao Zhang, Steve R. Roof, Hsiang-Ting Ho, Lucia Brunello, Jessica K. Lerch, Noah Weisleder, Vadim V. Fedorov, Federica Accornero, Jill A. Rafael-Fortney, Sandor Gyorke, Paul M. L. Janssen, Brandon J. Biesiadecki, Mark T. Ziolo, Jonathan P. Davis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Heart contraction, which is decreased in disease, is determined by Ca2+binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Tropo
Externí odkaz:
https://doaj.org/article/9828c585327046c3b5306a0cb5e0d215
Autor:
Kathryn M Madalena, Jessica K Lerch
Publikováno v:
Neural Regeneration Research, Vol 11, Iss 1, Pp 37-41 (2016)
Glucocorticoid and glucocorticoid receptor (GC/GR) interactions alter numerous aspects of neuronal function. These consequences (e.g., anti-inflammatory vs. pro-inflammatory) can vary depending on the duration of GC exposure or central nervous system
Externí odkaz:
https://doaj.org/article/dbfe615fb085470382c90072ead14574
Autor:
Hannah R. Bulgart, Kathryn M. Madalena, Rohan Mital, Kevin E. McElhanon, Thomas A. Kwiatkowski, Aubrey L. Rose, Jessica K. Lerch, Miguel A. Lopez Perez, Brian J. Paleo, Noah L. Weisleder
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdfc4ded8cdb60791616d1adc6c1bc68
https://doi.org/10.1096/fasebj.2022.36.s1.r4564
https://doi.org/10.1096/fasebj.2022.36.s1.r4564
Autor:
Kathryn M. Madalena, Jessica K. Lerch
Publikováno v:
Neural Plasticity, Vol 2017 (2017)
Stress, injury, and disease trigger glucocorticoid (GC) elevation. Elevated GCs bind to the ubiquitously expressed glucocorticoid receptor (GR). While GRs are in every cell in the nervous system, the expression level varies, suggesting that diverse c
Externí odkaz:
https://doaj.org/article/789ac3d9f10e47ac9ec738b9a1e83f2e
Autor:
Hemalatha B Raju, Zoe Alexandra Englander, Enrico eCapobianco, Nick eTsinoremas, Jessica K Lerch
Publikováno v:
Frontiers in Genetics, Vol 5 (2014)
Neuropathic pain (NP) is caused by damage to the nervous system, resulting in dysfunction and aberrant pain. The cellular functions (e.g. peripheral neuron spinal cord innervation, neuronal excitability) associated with NP often develop over time and
Externí odkaz:
https://doaj.org/article/ee4d269f532040a1ac700a1c307b4708
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30417 (2012)
To fully understand cell type identity and function in the nervous system there is a need to understand neuronal gene expression at the level of isoform diversity. Here we applied Next Generation Sequencing of the transcriptome (RNA-Seq) to purified
Externí odkaz:
https://doaj.org/article/ccd395b1712a4aac885b8c640c162469
Autor:
Daniel B. McKim, John F. Sheridan, Timothy D. Faw, Michelle L. Humeidan, Jessica K. Lerch, Jonathan P. Godbout, Caroline M. Sawicki, D. Michele Basso, January K. Kim, Kathryn M. Madalena, Michael D. Weber
Publikováno v:
The Journal of Neuroscience. 39:1139-1149
Clinical studies indicate that psychosocial stress contributes to adverse chronic pain outcomes in patients, but it is unclear how this is initiated or amplified by stress. Repeated social defeat (RSD) is a mouse model of psychosocial stress that act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfaad9ebd8eb338395f2a0c21d5240e6
https://doi.org/10.1523/jneurosci.2785-18.2018
https://doi.org/10.1523/jneurosci.2785-18.2018
Autor:
Tyler T Thaxton, Lesley C. Fisher, Rochelle J. Deibert, Timothy D. Faw, Jessica K. Lerch, D. Michele Basso
Publikováno v:
Journal of Neurotrauma. 35:2167-2182
Sensorimotor recovery after spinal cord injury (SCI) is of utmost importance to injured individuals and will rely on improved understanding of SCI pathology and recovery. Novel transgenic mouse lines facilitate discovery, but must be understood to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e843a2c909c45b3a298d58f8c230917
https://doi.org/10.1089/neu.2017.5395
https://doi.org/10.1089/neu.2017.5395
Autor:
Jessica K. Lerch, Dario Motti, Matt C. Danzi, Jared H. Gans, Tatiana I. Slepak, John L. Bixby, Vance Lemmon, Frank Kuo
Publikováno v:
FEBS Letters. 591:2091-2105
Peripheral neurons regenerate their axons after injury. Transcriptional regulation by microRNAs (miRNAs) is one possible mechanism controlling regeneration. We profiled miRNA expression in mouse dorsal root ganglion (DRG) neurons after a sciatic nerv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ad29f2e3b9f301a504eb4563f8bcf2
https://doi.org/10.1002/1873-3468.12718
https://doi.org/10.1002/1873-3468.12718