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Akademický článek

Opinion: The strength of long-term comprehensive observations to meet multiple grand challenges in different environments and in the atmosphere

Autor: M. Kulmala, A. Lintunen, H. Lappalainen, A. Virtanen, C. Yan, E. Ezhova, T. Nieminen, I. Riipinen, R. Makkonen, J. Tamminen, A.-M. Sundström, A. Arola, A. Hansel, K. Lehtinen, T. Vesala, T. Petäjä, J. Bäck, T. Kokkonen, V.-M. Kerminen

Publikováno v: Atmospheric Chemistry and Physics, Vol 23, Pp 14949-14971 (2023)

To be able to meet global grand challenges (climate change; biodiversity loss; environmental pollution; scarcity of water, food and energy supplies; acidification; deforestation; chemicalization; pandemics), which all are closely interlinked with eac

Externí odkaz: https://doaj.org/article/c5cc296396e14e3b92d6f548b9c77982

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Akademický článek

Deep-learning-based post-process correction of the aerosol parameters in the high-resolution Sentinel-3 Level-2 Synergy product

Autor: A. Lipponen, J. Reinvall, A. Väisänen, H. Taskinen, T. Lähivaara, L. Sogacheva, P. Kolmonen, K. Lehtinen, A. Arola, V. Kolehmainen

Publikováno v: Atmospheric Measurement Techniques, Vol 15, Pp 895-914 (2022)

Satellite-based aerosol retrievals provide global spatially distributed estimates of atmospheric aerosol parameters that are commonly needed in applications such as estimation of atmospherically corrected satellite data products, climate modelling an

Externí odkaz: https://doaj.org/article/f09c983fbc434d8cb3cfeb2b392b53bd

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Akademický článek

Effects of oligomerization and decomposition on the nanoparticle growth: a model study

Autor: A. Heitto, K. Lehtinen, T. Petäjä, F. Lopez-Hilfiker, J. A. Thornton, M. Kulmala, T. Yli-Juuti

Publikováno v: Atmospheric Chemistry and Physics, Vol 22, Pp 155-171 (2022)

The rate at which freshly formed secondary aerosol particles grow is an important factor in determining their climate impacts. The growth rate of atmospheric nanoparticles may be affected by particle-phase oligomerization and decomposition of condens

Externí odkaz: https://doaj.org/article/80717bcae11e44e5a414ca5d70025c1e

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Expanding the Paradigm of Structure-Based Drug Design: Molecular Dynamics Simulations Support the Development of New Pyridine-Based Protein Kinase C-Targeted Agonists

Autor: Saara Lautala, Riccardo Provenzani, Ilari Tarvainen, Katia Sirna, S. Tuuli Karhu, Evgeni Grazhdankin, Antti K. Lehtinen, Hanan Sa’d, Artturi Koivuniemi, Henri Xhaard, Raimo K. Tuominen, Virpi Talman, Alex Bunker, Jari Yli-Kauhaluoma

Publikováno v: Journal of Medicinal Chemistry. 66:4588-4602

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5245c1c32703c57ea1735d9e5ee0a4b
https://doi.org/10.1021/acs.jmedchem.2c01448

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The choroid plexus: a missing link in our understanding of brain development and function

Autor: Norman R. Saunders, Katarzyna M. Dziegielewska, Ryann M. Fame, Maria K. Lehtinen, Shane A. Liddelow

Publikováno v: Physiological Reviews. 103:919-956

Studies of the choroid plexus lag behind those of the more widely known blood-brain barrier, despite a much longer history. This review has two overall aims. The first is to outline long-standing areas of research where there are unanswered questions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa5535cfb80113b15f8f692cda35501
https://doi.org/10.1152/physrev.00060.2021

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Outcomes of the 2019 hydrocephalus association workshop, 'Driving common pathways: extending insights from posthemorrhagic hydrocephalus'

Autor: Jason K. Karimy, Jessie C. Newville, Cameron Sadegh, Jill A. Morris, Edwin S. Monuki, David D. Limbrick, James P. McAllister II, Jenna E. Koschnitzky, Maria K. Lehtinen, Lauren L. Jantzie

Publikováno v: Fluids and barriers of the CNS, vol 20, iss 1

The Hydrocephalus Association (HA) workshop, Driving Common Pathways: Extending Insights from Posthemorrhagic Hydrocephalus, was held on November 4 and 5, 2019 at Washington University in St. Louis. The workshop brought together a diverse group of ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834dbeff0eae75b9b942b82ac3bc882a
https://escholarship.org/uc/item/8n16r8s9

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Akademický článek

Downregulation of ribosome biogenesis during early forebrain development

Autor: Kevin F Chau, Morgan L Shannon, Ryann M Fame, Erin Fonseca, Hillary Mullan, Matthew B Johnson, Anoop K Sendamarai, Mark W Springel, Benoit Laurent, Maria K Lehtinen

Publikováno v: eLife, Vol 7 (2018)

Forebrain precursor cells are dynamic during early brain development, yet the underlying molecular changes remain elusive. We observed major differences in transcriptional signatures of precursor cells from mouse forebrain at embryonic days E8.5 vs.

Externí odkaz: https://doaj.org/article/26917e227f1a4c0287793f92d79f7f26

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In utero intracerebroventricular delivery of adeno-associated viral vectors to target mouse choroid plexus and cerebrospinal fluid

Autor: Ahram Jang, Maria K. Lehtinen

Publikováno v: STAR protocols. 4(1)

Experimentally targeting mouse choroid plexus (ChP) provides a valuable approach for investigating mechanisms of ChP-cerebrospinal fluid (CSF) biology. Here, we provide a protocol to deliver adeno-associated viral vectors (AAVs) by in utero intracere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e1a330292063ba13fa651dc89f9c02
https://pubmed.ncbi.nlm.nih.gov/36580401

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