Výsledky vyhledávání - "K. Lee Stone"

Facile synthesis and initial PET imaging of novel potential heart acetylcholinesterase imaging agents [11C]pyridostigmine and its analogs

Autor: William J. Groh, John C. Lopshire, Gary D. Hutchins, Douglas P. Zipes, Michael A. Miller, K. Lee Stone, Qi Huang Zheng, Xiangshu Fei, Ji Quan Wang

Publikováno v: Nuclear Medicine and Biology. 31:957-964

A series of 11C-labeled analogs of the acetylcholinesterase (AChE) inhibitor pyridostigmine have been synthesized for evaluation as new potential positron emission tomography (PET) imaging agents for heart AChE. The appropriate precursors for radiola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df2c6179f73df81e55425245b3e6a29
https://doi.org/10.1016/j.nucmedbio.2004.04.005

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Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues

Autor: K. Lee Stone, Tanya D. Martinez, Qi Huang Zheng, Xiangshu Fei, Kathy D. Miller, George W. Sledge, Gary D. Hutchins, Ji Quan Wang

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:1247-1251

Radiolabeled antimitotic agents [11C]T138067 and [18F]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. In vivo biodistribution and micro-PET imaging of [11C]T138067 were p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53c0afe3193e1d29c061d8be8d801a6
https://doi.org/10.1016/j.bmcl.2003.12.061

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Comparative studies of potential cancer biomarkers carbon-11 labeled MMP inhibitors (S)-2-(4′-[11C]methoxybiphenyl-4-sulfonylamino)-3-methylbutyric acid and N-hydroxy-(R)-2-[[(4′-[11C]methoxyphenyl)sulfonyl]benzylamino]-3-methylbutanamide

Autor: Qi-Huang Zheng, Xiangshu Fei, Xuan Liu, Ji-Quan Wang, K Lee Stone, Tanya D Martinez, Dawn J Gay, Winston L Baity, Kathy D Miller, George W Sledge, Gary D Hutchins

Publikováno v: Nuclear Medicine and Biology. 31:77-85

(S)-2-(4'-[11C]methoxybiphenyl-4-sulfonylamino)-3-methylbutyric acid ([11C]MSMA) and N-hydroxy-(R)-2-[[(4'-[11C]methoxyphenyl)sulfonyl]benzylamino]-3-methylbutanamide ([11C]CGS 25966), carbon-11 labeled matrix metalloproteinase (MMP) inhibitors, have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db8c4d685c16005b40fa8ab349e22c8
https://doi.org/10.1016/s0969-8051(03)00111-2

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Synthesis, biodistribution and micro-PET imaging of a potential cancer biomarker carbon-11 labeled MMP inhibitor (2R)-2-[[4-(6-fluorohex-1-ynyl)phenyl]sulfonylamino]-3-methylbutyric acid [11C]methyl ester

Autor: Qi-Huang Zheng, Xiangshu Fei, Timothy R DeGrado, Ji-Quan Wang, K Lee Stone, Tanya D Martinez, Dawn J Gay, Winston L Baity, Bruce H Mock, Barbara E Glick-Wilson, Michael L Sullivan, Kathy D Miller, George W Sledge, Gary D Hutchins

Publikováno v: Nuclear Medicine and Biology. 30:753-760

(2R)-2-[[4-(6-fluorohex-1-ynyl)phenyl]sulfonylamino]-3-methylbutyric acid [(11)C]methyl ester ([(11)C]FMAME), a novel carbon-11 labeled matrix metalloproteinase (MMP) inhibitor, has been synthesized for evaluation as new potential positron emission t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885975b5c8ce6287a9c8736ba58553cd
https://doi.org/10.1016/s0969-8051(03)00086-6

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Synthesis and preliminary biological evaluation of radiolabeled O6-benzylguanine derivatives, new potential PET imaging agents for the DNA repair protein O6-alkylguanine-DNA alkyltransferase in breast cancer

Autor: David W. Ohannesian, Xuan Liu, Gary D. Hutchins, Ji-Quan Wang, K. Lee Stone, Xiangshu Fei, Qi Huang Zheng, Leonard C. Erickson

Publikováno v: Nuclear Medicine and Biology. 30:405-415

Novel radiolabeled O(6)-benzylguanine (O(6)-BG) derivatives, 2-amino-6-O-[(11)C]-[(methoxymethyl)benzyloxy]-9-methyl purines ([(11)C]p-O(6)-AMMP, 1a; [(11)C]m-O(6)-AMMP, 1b; [(11)C]o-O(6)-AMMP, 1c), 2-amino-6-O-benzyloxy-9-[(11)C]-[(methoxycarbonyl)m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::243211d1cd776027792d99c04be97300
https://doi.org/10.1016/s0969-8051(02)00447-x

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A Convenient Procedure for the Synthesis of O6-Benzylguanine Derivatives by Phase Transfer Catalysis

Autor: Barbara E. Glick-Wilson, Qi Huang Zheng, Gary D. Hutchins, Leonard C. Erickson, Xuan Liu, Kathy D. Miller, Bruce H. Mock, K. Lee Stone, Xiangshu Fei, Kathy A. Carlson, Wendy L. Winkle

Publikováno v: Synthetic Communications. 33:941-952

A convenient procedure by phase transfer catalysis has been developed for the synthesis of O6-BG (1) and its derivatives hydroxymethyl-BG (2a–c), halo-BG (3a–c, 4a–c, 5a–c, 6a–c), methoxy-BG (7), and methyl-BG (8). Compounds 2b, 2c, 4b, 4c,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d90ca07ad1e8cce1c9f6d3cd87fa633
https://doi.org/10.1081/scc-120016358

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Synthesis of MMP inhibitor radiotracer [11C]CGS 25966, a new potential pet tumor imaging agent

Autor: Ji Quan Wang, Gary D. Hutchins, Xuan Liu, Kathy D. Miller, Xiangshu Fei, George W. Sledge, K. Lee Stone, Qi Huang Zheng

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 46:343-351

[11C]CGS 25966, a novel radiolabeled matrix metalloproteinase (MMP) inhibitor, has been synthesized for evaluation as new potential positron emission tomography (PET) tumor imaging agent. The precursor was labeled by [11C]methyl triflate through O-[1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a86422b3d1885d53159a64a7a264c96
https://doi.org/10.1002/jlcr.675

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[11C]choline as a potential PET marker for imaging of breast cancer athymic mice

Autor: George W. Sledge, Qi Huang Zheng, Xuan Liu, Kathy D. Miller, Ji Quan Wang, Barbara E. Glick-Wilson, Xiangshu Fei, Gary D. Hutchins, Bruce H. Mock, K. Lee Stone

Publikováno v: Nuclear Medicine and Biology. 29:803-807

[11C]Choline has been evaluated as a potential positron emission tomography (PET) marker for imaging of breast cancer. The biodistribution of [11C]choline was determined at 45 min post iv injection in MCF-7's transfected with IL-1alpha implanted athy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc899462d85ff90790088daa9dfbfa4
https://doi.org/10.1016/s0969-8051(02)00339-6

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Synthesis of radiolabeled O6-benzylguanine derivatives as new potential PET tumor imaging agents for the DNA repair protein O6-alkylguanine-DNA alkyltransferase

Autor: Xuan Liu, Tanya D. Martinez, Kathy D. Miller, K. Lee Stone, Leonard C. Erickson, Qi Huang Zheng, Xiangshu Fei, Gary D. Hutchins, David W. Ohannesian, Ji-Quan Wang

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 45:1239-1252

Novel radiolabeled O6-benzylguanine derivatives, 2-amino-6-O-[11C]-[(methoxymethyl)benzyloxy]-9-benzyl purines ([11C]p-O6-AMBP, 1a; [11C]m-O6-AMBP, 1b; [11C]o-O6-AMBP, 1c), have been synthesized for evaluation as new potential positron emission tomog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3e7e6ea1729efb0036b2b37727a7ef6
https://doi.org/10.1002/jlcr.636

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Synthesis of MMP inhibitor radiotracers [11C]methyl-CGS 27023A and its analogs, new potential PET breast cancer imaging agents

Autor: Gary D. Hutchins, Xuan Liu, Xiangshu Fei, Wendy L. Winkle, George W. Sledge, K. Lee Stone, Barbara E. Glick-Wilson, Rose S. Fife, Qi Huang Zheng, Kathy D. Miller, Raymond E. Carr, Hui Bin Sun, Bruce H. Mock, Kathy A. Carlson

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 45:449-470

[11C]Methyl-CGS 27023A (1a) and its analogs [11C]methyl-2-picolyl-CGS 27023A (1b), [11C]methyl-benzyl-CGS 27023A (1c), [11C]methyl-2-nitro-CGS 27023A (1d), [11C]methyl-3-nitro-CGS 27023A (1e), and [11C]methyl-4-nitro-CGS 27023A (1f), novel radiolabel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4cab327a55e1515c9389e18b3adbc53
https://doi.org/10.1002/jlcr.570

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