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Akademický článek

New Polish cultivars of flax resistant to Fusarium wilt

Autor: A. Andruszewska, K. Langner, M. Byczyńska

Publikováno v: Plant Protection Science, Vol 38, Iss SI 2 - 6th Conf EFPP, Pp 565-568 (2002)

The breeders consider the lack of resistance of fibrous flax cultivars to Fusarium wilt the main problem in flax cultivation in Poland. The resistance to diseases, lodging, the quality of fiber and adaptation to local climatic conditions are the main

Externí odkaz: https://doaj.org/article/eba6b0939dfb46f9bc31cb85486189b3

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Akademický článek

Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention

Autor: Gabrijela Dumbović, Ulrich Braunschweig, Heera K. Langner, Michael Smallegan, Josep Biayna, Evan P. Hass, Katarzyna Jastrzebska, Benjamin Blencowe, Thomas R. Cech, Marvin H. Caruthers, John L. Rinn

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

RNA localization plays an important role in transcriptome regulation. The majority of TERT transcripts are detected in the nucleus and TUG1 lncRNAs in both the nucleus and cytoplasm. Here, the authors combine single-cell RNA imaging, antisense oligon

Externí odkaz: https://doaj.org/article/0a69eec1edfb49478cd0ef2274c07334

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Assessment of a compounded synthetic adrenocorticotropic hormone product in 17 healthy dogs

Autor: W Yang, G Hosgood, S Foster, K Langner, D Hayward, M Thompson

Publikováno v: Australian Veterinary Journal. 101:127-132

Synthetic adrenocorticotropic hormone or tetracosactide is routinely used in the diagnosis of hypoadrenocorticism and frequently in the diagnosis and treatment of hyperadrenocorticism. There have been repeated shortages of tetracosactide in recent ye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530fe0752e2803a5eac296241e4bbb5f
https://doi.org/10.1111/avj.13225

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Synthesis and Characterization of Thiophosphoramidate Morpholino Oligonucleotides and Chimeras

Autor: Heera K. Langner, Katarzyna Jastrzebska, Marvin H. Caruthers

Publikováno v: Journal of the American Chemical Society. 142:16240-16253

This Article outlines the optimized chemical synthesis and preliminary biochemical characterization of a new oligonucleotide analogue called thiophosphoramidate morpholinos (TMOs). Their rational design hinges upon integrating two well-studied pharma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce90a19003ff244647641fce6baac89
https://doi.org/10.1021/jacs.0c04335

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Akademický článek

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Akademický článek

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Akademický článek

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Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention

Autor: John L. Rinn, Evan P. Hass, Marvin H. Caruthers, Katarzyna Jastrzebska, Josep Biayna, Ulrich Braunschweig, Heera K. Langner, Gabrijela Dumbovic, Benjamin J. Blencowe, Michael J. Smallegan, Thomas R. Cech

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

The spatial partitioning of the transcriptome in the cell is an important form of gene-expression regulation. Here, we address how intron retention influences the spatio-temporal dynamics of transcripts from two clinically relevant genes: TERT (Telom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5077cf0354d59af55e2f2076738a02
http://europepmc.org/articles/PMC8175569

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Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA transcripts is driven by intron retention: implications for RNA-directed therapies

Autor: Benjamin J. Blencowe, Gabrijela Dumbovic, Heera K. Langner, Katarzyna Jastrzebska, Marvin H. Caruthers, John L. Rinn, Ulrich Braunschweig, Thomas R. Cech, Michael J. Smallegan

Numerous global connections have been made between splicing and other layers of gene regulation, including the spatial partitioning of the transcriptome in the cell. Yet, there has been surprisingly little analysis of the spatio-temporal regulation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b842d71c5d6803be55b806f01ddc5cc5
https://doi.org/10.1101/2020.07.21.212514

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