Zobrazeno 1 - 10 of 36 pro vyhledávání: '"K. L. Powell"'
1
Inhibition of Influenza A and B Viruses by 2′-Deoxy-2′-Fluororibosides
Autor: K. L. Powell, Margaret Tisdale, G. Darby, G. Appleyard, D. J. Nelson, D. J. M. Purifoy, W. Al Nakib, J. N. Stables, J. V. Tuttle, S. Nusinoff-Lehrman
Publikováno v: Antiviral Chemistry and Chemotherapy. 4:281-287
A series of 2′-deoxy-2′-fluororibosides were evaluated for anti-influenza activity in cell culture and in the mouse pneumonia model. Many were found to be potent inhibitors of Influenza A, in chick embryo fibroblast cells (IC50's 0.1–2.9 μM),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c87d772299a233145593d336e2fefaa9
https://doi.org/10.1177/095632029300400504
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3
Reaction of nontoxic, potentially chemopreventive purinethiols with a direct-acting, electrophilic carcinogen, benzo[a]pyrene-7,8-diol 9,10-epoxide
Autor: Wei-Guo Qing, Frederick E. Evans, Anne Daylong, K. L. Powell, Michael C. MacLeod
Publikováno v: Chemical Research in Toxicology. 6:159-167
Several nontoxic purinethiols have been shown to block the ability of the carcinogen 7-r,8-t-dihydroxy-9-t,10-t-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) to bind covalently to DNA in Chinese hamster ovary cells. Two of these compounds also block B
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d312bbe808566ba9ffcb8a67674099e8
https://doi.org/10.1021/tx00032a004
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4
Review of research leading to new anti-herpesvirus agents in clinical development: Valaciclovir hydrochloride (256u, the L-valyl ester of acyclovir) and 882c, a specific agent for varicella zoster virus
Autor: G B Roberts, G. Darby, P de Miranda, S. Lacey, K. L. Powell, Lilia M. Beauchamp, S. G. Rahim, D. J. M. Purifoy, P. Ertl, Thomas A. Krenitsky
Publikováno v: Journal of Medical Virology. 41:139-145
Research leading to the new anti-herpesvirus compounds discussed here has come from three approaches. The first approach was directed towards improving the bioavailability of acyclovir by examining the potential of a variety of prodrugs, leading to t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2182cf99752b41dfd58afe84a982d75e
https://doi.org/10.1002/jmv.1890410527
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5
5-Alkynyl Pyrimidine Nucleosides as Potent Selective Inhibitors of Varicella-Zoster Virus
Autor: Graham Darby, S. G. Rahim, J. Selway, P. Collins, N. Trevidi, K. L. Powell, D. J. M. Purifoy
Publikováno v: Antiviral Chemistry and Chemotherapy. 3:293-297
A series of 5-alkynyl substituted 2′-deoxyuridine and β-D-arabinofuranosyluracil nucleosides were synthesized and evaluated for in vitro activity against varicella-zoster virus (VZV). Three promising analogues, 1-(β-D-arabinofuranosyl)-5-ethynylu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::148ddad6926e8eb70987bdccf1207b8e
https://doi.org/10.1177/095632029200300507
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6
High level expression of DNA polymerases from herpesviruses
Autor: K. L. Powell, M. S. Thomas, P. F. Ertl
Publikováno v: Journal of General Virology. 72:1729-1734
The DNA polymerase genes of human cytomegalovirus (HCMV) and varicella-zoster virus (VZV) were inserted separately into the polyhedrin gene of Autographa californica nuclear polyhedrosis virus (AcNPV) by cotransfection of Spodoptera frugiperda (SF9)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb993449cd31e3bd3dfb3f9994a3dfb6
https://doi.org/10.1099/0022-1317-72-7-1729
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7
Analysis of mutations in the thymidine kinase genes of drug-resistant varicella-zoster virus populations using the polymerase chain reaction
Autor: Simon F. Lacey, K. L. Powell, D. J. M. Purifoy, T. Suzutani, R. W. Honess
Publikováno v: Journal of General Virology. 72:623-630
We have applied the polymerase chain reaction (PCR) technique to analyse mutations in the thymidine kinase (TK) gene of varicella-zoster virus (VZV) associated with resistance to the 5-bromovinyl (BVaraU) and 5-propynyl (PYaraU) analogues of arabinof
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b4ea8ce6f3cbee618d990f7a34c2f1
https://doi.org/10.1099/0022-1317-72-3-623
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8
High-affinity binding of the cell cycle-regulated transcription factors E2F1 and E2F4 to benzo[a]pyrene diol epoxide-DNA adducts
Autor: D G, Johnson, A, Coleman, K L, Powell, M C, MacLeod
Publikováno v: Molecular carcinogenesis. 20(2)
Previous studies indicated that DNA adducts formed by a carcinogenic diol epoxide, 7r,8t-dihydroxy-9t, 10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), can increase the affinity of the transcription factor Sp1 for DNA sequences that are not normal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4be86c9f55a21ed78cabcec3891a64d4
https://pubmed.ncbi.nlm.nih.gov/9364211
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9
Kinetics of the reaction of a potential chemopreventive agent, 2,6-dithiopurine, and its major metabolite, 2,6-dithiouric acid, with multiple classes of electrophilic toxicants
Autor: Michael C. MacLeod, K. L. Powell, Wei-Guo Qing
Publikováno v: Chemical research in toxicology. 9(8)
Purinethiols are a class of potential cancer chemopreventive agents that exhibit nucleophilic scavenging activity against the carcinogenic electrophile benzo[a]pyrene diol epoxide (BPDE). Of the purinethiols tested previously, 2,6-dithiopurine (DTP),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee604a79d9512db3e38fcf597a223ee
https://pubmed.ncbi.nlm.nih.gov/8951232
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10
Interference of benzo[a]pyrene diol epoxide-deoxyguanosine adducts in a GC box with binding of the transcription factor Sp1
Autor: M C, MacLeod, K L, Powell, V A, Kuzmin, A, Kolbanovskiy, N E, Geacintov
Publikováno v: Molecular carcinogenesis. 16(1)
Previous studies indicated that DNA adducts formed by the carcinogenic diol epoxide 7r,8t-dihydroxy-9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) can increase the affinity of the transcription factor Sp1 for DNA sequences that are not normall
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0326c4a2964de2eff953c67b217bd72
https://pubmed.ncbi.nlm.nih.gov/8634093
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