Zobrazeno 1 - 10
of 81
pro vyhledávání: '"K. L. Brigham"'
Autor:
K L Brigham, A A Stecenko
Publikováno v:
Gene Therapy. 10:95-99
Over the 2 years covered here, there has been one clinical study in which a normal alpha-1 antitrypsin (AAT) gene was delivered to the nasal epithelium of AAT-deficient subjects using plasmid-liposome complexes; a second study using an adeno-associat
Autor:
James R. Gossage, E. A. Perkett, D. Carmichael, B. Meyrick, B. C. Starcher, K. L. Brigham, Jeffrey M. Davidson
Publikováno v:
Journal of Applied Physiology. 79:1163-1172
Continuous air embolization (CAE) into the pulmonary arterial circulation of sheep results in functional and structural changes of chronic pulmonary hypertension. Release of elastin peptides into lung lymph during CAE and attenuation of CAE-induced p
Publikováno v:
Journal of Applied Physiology. 68:2542-2549
The macrophage- and monocyte-produced cytokine tumor necrosis factor alpha (TNF alpha) has been proposed as a major mediator of endotoxin-induced injury. To determine if TNF alpha could reproduce the effects of endotoxin on the lung, we intravenously
Autor:
A A, Stecenko, G, King, K, Torii, R M, Breyer, R, Dworski, T S, Blackwell, J W, Christman, K L, Brigham
Publikováno v:
Inflammation. 25(3)
Although pulmonary inflammation is an important pathologic event in cystic fibrosis (CF), the relationship between expression of the CF gene and the inflammatory response is unclear. We studied tumor necrosis factor (TNF) alpha and IL-1beta stimulate
Publikováno v:
Transplantation proceedings. 28(2)
Autor:
K L, Brigham, A A, Stecenko
Publikováno v:
New horizons (Baltimore, Md.). 3(2)
The development of techniques for manipulating nucleic acids and strategies for delivering DNA to humans has made gene therapy a reality. Although mostly focused on genetically based diseases so far, there is every reason to expand the concept to inc
Autor:
A. P. Wheeler, K. L. Brigham
Publikováno v:
Therapeutic Antibodies ISBN: 9781447119395
Sepsis syndrome is a constellation of clinical findings that includes three major features: a site of inflammation; presence of abnormal vital signs (altered temperature, tachycardia and an increased minute ventilation); and at least one organ system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4212e4e105d890f1eff6db8fdc9dfb1
https://doi.org/10.1007/978-1-4471-1937-1_10
https://doi.org/10.1007/978-1-4471-1937-1_10
Autor:
G R, Bernard, A, Artigas, K L, Brigham, J, Carlet, K, Falke, L, Hudson, M, Lamy, J R, LeGall, A, Morris, R, Spragg
Publikováno v:
Journal of critical care. 9(1)
The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity rate, mortality rate (10% to 90%), and financial cost. The reported annual inc
Publikováno v:
Progress in clinical and biological research. 388
The concept of gene therapy may be broadened to include transient gene therapy (gene therapeutics) as a potential intervention in prevention and treatment of diseases which are a consequence of triggering the inflammatory response. Functioning genes
Publikováno v:
Update in Intensive Care and Emergency Medicine ISBN: 9783642850387
It now appears that much of the tissue injury which occurs in sepsis is a consequence of the inflammatory response run amok. This conclusion seemed first apparent when it became clear that the accumulation of neutrophils and their activation was inti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b8ec035434f5643df0bce818c6678a3
https://doi.org/10.1007/978-3-642-85036-3_40
https://doi.org/10.1007/978-3-642-85036-3_40