Zobrazeno 1 - 10
of 28
pro vyhledávání: '"K. Kumar Changani"'
Publikováno v:
Cell Preservation Technology. 1:105-109
A technique is described to perform magnetic resonance spectroscopy (MRS) studies at hypothermia on human donor livers in a prospective fashion in the time interval between organ flushing and subse...
Autor:
Humphrey Hodgson, Camilla Buckley, K. Kumar Changani, Simon D. Taylor-Robinson, Jimmy D. Bell
Publikováno v:
Liver International. 19:389-398
Background/Aims: In vivo magnetic resonance spectroscopy can be used to study cerebral metabolism non-invasively. We aimed to correlate 1H and 31P magnetic resonance spectral abnormalities in the brains of patients with subclinical hepatic encephalop
Autor:
Barry Fuller, Brian R. Davidson, S. Mierisova, DJ Bryant, Mika Ala-Korpela, Jimmy D. Bell, Simon D. Taylor-Robinson, K. Kumar Changani
Publikováno v:
NMR in Biomedicine. 12:197-204
A semi-automated, metabolite prior-knowledge-based, lineshape fitting analysis has been developed to assess the dynamic biochemical changes found in ex vivo31P NMR pig liver preservation studies. Due to the inherent experimental limitations of the ex
Autor:
Gabriele Jenkinson, Simon D. Taylor-Robinson, Jane E Schwieso, John P. Seery, Henry J Houlden, Humphrey Hodgson, David J. Bryant, K. Kumar Changani
Publikováno v:
Hepatology Research. 12:50-58
We report the case of an insulin-dependent diabetic with persistent abdominal pain secondary to non-alcohol-related hepatic steatosis which was unrelieved with standard analgesia. The pain responded to regular intravenous infusion of polyunsaturated
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1380:198-208
In vivo 13C-NMR was employed to determine the hepatic fate of infused [1-13C]-d-glucose (200 mg/kg) following ad libitum or routine meal feeding (RMF) regimes imposed during pregnancy. Hepatic glycogen synthesis was measured immediately following the
Autor:
Simon D. Taylor-Robinson, Mika Ala-Korpela, Brian R. Davidson, Jimmy D. Bell, K. Kumar Changani, David J. Bryant, Yrjö Hiltunen, Barry Fuller
Publikováno v:
Magnetic Resonance in Medicine. 38:840-844
Quantitative artificial neural network analysis for 1550 ex vivo 31P nuclear magnetic resonance spectra from hypothermically reperfused pig livers was assessed. These spectra show wide ranges of metabolite concentrations and have been analyzed using
Publikováno v:
Liver Transplantation and Surgery. 3:481-493
Magnetic resonance spectroscopy (MRS) allows the noninvasive measurement of whole organ metabolism due to the presence of the MR-sensitive nucleus phosphorus 31 in adenosine triphosphate (ATP), its precursors, and break-down products. In small animal
Autor:
Richard A. Iles, Steve C.R. Williams, E. L. Thomas, Jimmy D. Bell, S.R. Bloom, Maria L. Barnard, K. Kumar Changani
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1335:290-304
This study set out to validate the use of 31P-NMR spectroscopy together with alanine +/- glucagon infusions to assess hepatic gluconeogenic flux in vivo. Bolus infusions of alanine (2.8 or 5.6 mmol/kg) +/- glucagon (250 microg/kg) were used. Maximal
Autor:
Barry Fuller, Simon D. Taylor-Robinson, David J. Bryant, Brian R. Davidson, K. Kumar Changani, Jimmy D. Bell, Mika Ala-Korpela, Duncan P. Moore
Publikováno v:
Journal of Hepatology. 26:336-342
We have developed a quick, non-invasive method for measuring the ability of an isolated preserved liver to regenerate high energy phosphate nucleotides without the need for biopsy. Using 31P MRS we have monitored the hepatic energetics of intact cold
Publikováno v:
Scandinavian Journal of Urology and Nephrology. 31:487-492
Renal transplant programmes are seriously limited by the continuing shortage of donor organs. Kidneys from marginal and non-heart-beating donors are increasingly being used, but their viability may be compromised. There is currently no rapid yet accu