Zobrazeno 1 - 10
of 469
pro vyhledávání: '"K. Knutson"'
Autor:
Jef D. Boeke, Kathleen H. Burns, Katherine B. Chiappinelli, Marie Classon, John M. Coffin, Daniel D. DeCarvalho, Joseph D. Dukes, Benjamin Greenbaum, George Kassiotis, Sarah K. Knutson, Arnold J. Levine, Avindra Nath, Sophie Papa, Daniel Rios, John Sedivy, David T. Ting
Publikováno v:
Mobile DNA, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract In November 2022 the first Dark Genome Symposium was held in Boston, USA. The meeting was hosted by Rome Therapeutics and Enara Bio, two biotechnology companies working on translating our growing understanding of this vast genetic landscape
Externí odkaz:
https://doaj.org/article/afb42101dc1c4afbabb0c6b4ea01ef97
Autor:
Samantha M. Cady, David W. Londe, Samuel D. Fuhlendorf, Craig A. Davis, Abraham J. Kanz, Kiera L. Kauffman, Jennifer K. Knutson, Alexander G. Barnes, Nicholas A. McMillan, Landon K. Neumann
Publikováno v:
Global Ecology and Conservation, Vol 46, Iss , Pp e02544- (2023)
Recognizing the vulnerability of natural systems to anthropogenic climate change, government agencies and private sector institutions have begun to incorporate climate change action planning into natural resource management practices. Because curatin
Externí odkaz:
https://doaj.org/article/80bb36eeee4c4777bf7d7f0ef8bbd8ec
Autor:
Valérie J. Robert, Andrew K. Knutson, Andreas Rechtsteiner, Steven Garvis, Gaël Yvert, Susan Strome, Francesca Palladino
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Chromatin regulators contribute to the maintenance of the germline transcriptional program. In the absence of SET-2, the Caenorhabditis elegans homolog of the SET1/COMPASS H3 Lys4 (H3K4) methyltransferase, animals show transgenerational loss of germl
Externí odkaz:
https://doaj.org/article/c46606b0b05746aba3d8f3388c518cde
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
XLSX file - 132K, Table S2: Effects of EPZ-6438 on Gene Expression in EZH2 Mutant Lymphoma Cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5ead92a929cc4e895624b9120695df
https://doi.org/10.1158/1535-7163.22499889.v1
https://doi.org/10.1158/1535-7163.22499889.v1
Autor:
Scott A. Ribich, Heike Keilhack, Jesse J. Smith, Richard Chesworth, Robert A. Copeland, Peter Ho, John Campbell, Maria Roche, Kristy Kuplast-Barr, Sarah K. Knutson, Igor Feldman, Alexandra R. Grassian, Allison Drew, Kelli Armstrong, Elayne Chan-Penebre
The SWI/SNF complex is a major regulator of gene expression and is increasingly thought to play an important role in human cancer, as evidenced by the high frequency of subunit mutations across virtually all cancer types. We previously reported that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f0193e841ebe292cdd7fd3a4087a01
https://doi.org/10.1158/1535-7163.c.6537771.v1
https://doi.org/10.1158/1535-7163.c.6537771.v1
Autor:
Michael J. Thomenius, Alejandra Raimondi, Scott A. Ribich, Sarah K. Knutson, Elayne Chan-Penebre, Heike Keilhack, Robert A. Copeland, Jesse J. Smith, Christopher Plescia, Igor Feldman, Natalie M. Warholic, Vinny Motwani, Trupti Lingaraj, Allison Drew, Danielle Johnston-Blackwell, Dorothy Brach
The EZH2 small-molecule inhibitor tazemetostat (EPZ-6438) is currently being evaluated in phase II clinical trials for the treatment of non-Hodgkin lymphoma (NHL). We have previously shown that EZH2 inhibitors display an antiproliferative effect in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16635ec96cb32a617f49970fa6370768
https://doi.org/10.1158/1535-7163.c.6539623.v1
https://doi.org/10.1158/1535-7163.c.6539623.v1
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
PDF file - 811K, Fig. S1. Effects of EPZ-6438 on Gene Promoter H3K27 Methylation, Recruitment of PRC2 Components to Gene Promoters, and Cell Cycle, in WSU-DLCL2 Cells. Fig. S2: Effects of EPZ-6438 on Gene Expression in EZH2 Mutant Lymphoma Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fcbfa5d3e9bdddeac3c8f600a70bce
https://doi.org/10.1158/1535-7163.22499898.v1
https://doi.org/10.1158/1535-7163.22499898.v1
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
PDF file - 25K, Table S1: LCC Values for EPZ-6438 for WSU-DLCL2 Human Lymphoma Cells Dosed Either Continuously or After Compound Washout.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12304f9a85f43c2b5fe15a51c85b039b
https://doi.org/10.1158/1535-7163.22499892
https://doi.org/10.1158/1535-7163.22499892
Autor:
Michael J. Thomenius, Alejandra Raimondi, Scott A. Ribich, Sarah K. Knutson, Elayne Chan-Penebre, Heike Keilhack, Robert A. Copeland, Jesse J. Smith, Christopher Plescia, Igor Feldman, Natalie M. Warholic, Vinny Motwani, Trupti Lingaraj, Allison Drew, Danielle Johnston-Blackwell, Dorothy Brach
Table S1: Conditions and seeding densities of all cell lines used in studies; Table S2. Single agent IC50 values for agents tested for 3 days in 96-well plates as described in Materials and Methods; Figure S1. Tazemetostat dosing reduced H3K27me3 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028053566081cf3c139a50ed258075a7
https://doi.org/10.1158/1535-7163.22510432
https://doi.org/10.1158/1535-7163.22510432
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
Mutations within the catalytic domain of the histone methyltransferase EZH2 have been identified in subsets of patients with non-Hodgkin lymphoma (NHL). These genetic alterations are hypothesized to confer an oncogenic dependency on EZH2 enzymatic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f9ced2f5eb38e4c70192dc2fd63ef50
https://doi.org/10.1158/1535-7163.c.6536301
https://doi.org/10.1158/1535-7163.c.6536301