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of 20
pro vyhledávání: '"K. Kellings"'
Autor:
Jiri G. Safar, Darlene Groth, K. Kellings, Stanley B. Prusiner, Detlev Riesner, James E. Cleaver, Ana Serban
Publikováno v:
Journal of Virology. 79:10796-10806
Diversity of prion strains was attributed to an elusive nucleic acid, yet a search spanning nearly two decades has failed to identify a prion-specific polynucleotide. In our search for a prion-specific nucleic acid, we analyzed nucleic acids in purif
Publikováno v:
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 343:425-430
As recently published (Kellings et al. J. gen Vir. 73, 1025-1029 (1992)), the analysis of purified scrapie prions by return refocusing gel electrophoresis revealed remaining nucleic acids in the size range up to 1100 nucleotides. The results defined
Publikováno v:
Journal of General Virology. 73:1025-1029
Although increasingly unlikely, the possibility of a scrapie-specific nucleic acid carried by infectious prion particles is still unresolved. Return refocusing gel electrophoresis was developed to detect homogeneous and heterogeneous nucleic acids ex
Autor:
Stanley B. Prusiner, Darlene Groth, Holger Wille, Hana Serban, Martin Pitschke, Detlev Riesner, Michael A. Baldwin, Karin Post, K. Kellings
Publikováno v:
Prions and Brain Diseases in Animals and Humans ISBN: 9781489918987
Prions are composed largely, if not entirely, of an abnormal isoform of the prion protein (PrP) designated PrPSc. A protease resistant polypeptide, PrP 27–30, can be derived from PrPSc by limited proteolysis with retention of infectivity. Both PrPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b98ae9342573d6ae2e46a768a9fdc32
https://doi.org/10.1007/978-1-4899-1896-3_23
https://doi.org/10.1007/978-1-4899-1896-3_23
Autor:
Holger Wille, D Groth, H Serban, Stanley B. Prusiner, M A Baldwin, K. Kellings, Karin Post, Detlev Riesner
Publikováno v:
Journal of virology. 70(3)
An abnormal isoform of the prion protein (PrP) designated PrPSc is the major, or possibly the only, component of infectious prions. Structural studies of PrPSc have been impeded by its lack of solubility under conditions in which infectivity is retai
Publikováno v:
Archives of virology. Supplementum. 7
Amount, type, and size of nucleic acid molecules associated with purified prion preparations were analyzed. Return refocusing gel electrophoresis (RRGE) was developed to detect homogeneous and heterogeneous nucleic acids extracted from highly purifie
Publikováno v:
Developments in biological standardization. 80
Studies on prions involve nucleic acid chemistry under two headings: i) do infectious prion particles contain nucleic acids? ii) is it possible by a simple procedure to screen the prion protein (PrP)-gene for mutations? The return refocusing gel elec
Publikováno v:
Unconventional Agents and Unclassified Viruses ISBN: 9783211824801
Amount, type, and size of nucleic acid molecules associated with purified prion preparations were analyzed. Return refocusing gel electrophoresis (RRGE) was developed to detect homogeneous and heterogeneous nucleic acids extracted from highly purifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be256a7619f774b0ec68b91498911d64
https://doi.org/10.1007/978-3-7091-9300-6_17
https://doi.org/10.1007/978-3-7091-9300-6_17
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