Zobrazeno 1 - 10
of 32
pro vyhledávání: '"K. K. Morella"'
Autor:
Heinz Baumann, Pascal S. Bailon, Chun-Fai Lai, Marlene Dembski, K. K. Morella, David White, Louis A. Tartaglia, Hongkyun Kim
Publikováno v:
Proceedings of the National Academy of Sciences. 93:8374-8378
The leptin receptor (OB-R) is a single membrane-spanning protein that mediates the weight regulatory effects of leptin (OB protein). The mutant allele (db) of the OB-R gene encodes a protein with a truncated cytoplasmic domain that is predicted to be
Autor:
Nelson D. Horseman, Heinz Baumann, K. K. Morella, Susana P. Campos, Juergen Ripperger, Chun-Fai Lai, David P. Gearing, Yanping Wang, G H Fey
Publikováno v:
Journal of Biological Chemistry. 270:23254-23257
Transient transfection of expression vectors for various members of the hematopoietin receptor family and STAT proteins into COS-1 cells indicated that each receptor was capable of stimulating the DNA binding activity of STAT1, STAT3, and STAT5B. How
Autor:
Heinz Baumann, Chun-Fai Lai, K. K. Morella, Juergen Ripperger, Georg H. Fey, Susana P. Campos, Yanping Wang, David P. Gearing
Publikováno v:
Blood. 86:1671-1679
To determine the specificity of signal transducer and activator of transcription (STAT) protein activation by box 3 motif-deficient hematopoietin receptors, expression vectors encoding the receptors for growth hormone, interleukin-3 (IL-3), and IL-4
Autor:
S Kumaki, K. K. Morella, E Bruno, Chun-Fai Lai, L Benit, R Hoffman, Martin Timour, HM Wang, J Fu, L Murray
Publikováno v:
Blood. 86:557-571
Antisense oligonucleotide to the translation initiation sequence of human c-mpI reduced the proliferation of human CD34+ bone marrow cells in response to interleukin-3 (IL-3) alone or to the combination of IL-3 and thrombopoietin (TPO). To investigat
Publikováno v:
The Journal of Immunology. 151:4248-4257
In rat hepatoma H-35 cells, TNF-alpha, like IL-1 beta, stimulates the synthesis and secretion of type 1 acute phase plasma proteins, including alpha 1-acid glycoprotein (AGP), complement component 3 (C3), hemopexin, and haptoglobin. TNF and IL-1 in c
Publikováno v:
Journal of Biological Chemistry. 268:10495-10500
In the rat hepatoma (HTC) cell line, transcription of the alpha 1-acid glycoprotein (AGP) gene is prominently stimulated by dexamethasone. Although interleukin (IL)-1 and IL-6 synergistically enhance expression of the AGP gene in liver, they have no
Publikováno v:
Molecular and Cellular Biology. 13:2384-2390
Using two different cell systems, we show that the cytoplasmic domain of the granulocyte-colony-stimulating factor receptor (G-CSFR) may be composed of at least two functional regions. The first, within the membrane-proximal 57 amino acids, is absolu
Publikováno v:
Journal of Biological Chemistry. 268:8414-8417
Ciliary neurotrophic factor (CNTF) has been described as a neuro-active cytokine that shares functional similarities with the leukemia inhibitory factor (LIF). We demonstrate here that, like LIF, CNTF stimulates expression of acute phase plasma prote
Publikováno v:
Journal of Biological Chemistry. 267:19744-19751
Rat hepatic cells respond to interleukin (IL) -1, IL-6, and dexamethasone treatment by increasing the transcription rate of acute-phase plasma protein genes. The same conditions lead to changes in the expression of CAAT-enhancer binding protein (C/EB
Autor:
Kwang-Ai Won, Steven C. Pruitt, V. E. Jones, K. K. Morella, Karen R. Prowse, Gerald P. Jahreis, Heinz Baumann
Publikováno v:
Journal of Biological Chemistry. 266:20390-20399
Independent of de novo protein synthesis, interleukin-1, interleukin-6, and dexamethasone caused immediate stimulation of transcriptional activity of most major acute phase plasma protein genes in the rat hepatoma H-35 cells. However, activation of a