Výsledky vyhledávání - "K. K. Changani"

Role of Magnetic Resonance in Drug Development

Autor: J. D. Kaggie, M. V. Haase, S. P. Campbell, C. M. Wright, M. J. Graves, K. K. Changani

Publikováno v: Modern Magnetic Resonance ISBN: 9783319282756

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdceeb96d157e0ab2efb0ebfa368a99d
https://doi.org/10.1007/978-3-319-28275-6_101-1

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Chapter 8.3. MRI in Practical Drug Discovery

Autor: M. V. Fachiri, K. K. Changani, S. Hotee

Drug discovery and development is a resource intensive and risky process. Compound failure rates remain high and principally occur in the most expensive clinical stages of pharmaceutical research. There is therefore considerable interest in the appli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19fbabec02d93ef1c52cc623665a8f8d
https://doi.org/10.1039/9781849732918-00465

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Rapid reversal of hepatic steatosis, and reduction of muscle triglyceride, by rosiglitazone: MRI/S studies in Zucker fatty rats

Autor: P D, Hockings, K K, Changani, N, Saeed, D G, Reid, J, Birmingham, P, O'Brien, J, Osborne, C N, Toseland, R E, Buckingham

Publikováno v: Diabetes, obesitymetabolism. 5(4)

This study aimed to chart the time course and durability of the effects of rosiglitazone, a potent thiazolidinedione-based peroxisome proliferator-activated receptor gamma agonist, on hepatic steatosis and intramyocellular lipid in an animal model of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5eefa7d854d272584db9d9dcc5581ddd
https://pubmed.ncbi.nlm.nih.gov/12795656

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A longitudinal magnetic resonance imaging (MRI) study of differences in abdominal fat distribution between normal mice, and lean overexpressers of mitochondrial uncoupling protein-3 (UCP-3)

Autor: K K, Changani, A, Nicholson, A, White, J K, Latcham, D G, Reid, J C, Clapham

Publikováno v: Diabetes, obesitymetabolism. 5(2)

To characterize evolution and distribution of abdominal adipose fat between 6 and 18 weeks of age in an animal model of energy consumption based on mice overexpressing the mitochondrial uncoupler protein 3 (UCP-3).T2-weighted multislice MRI was perfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c989bcee4deb5fc0ab18de9c8818b6ba
https://pubmed.ncbi.nlm.nih.gov/12630934

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Improved preservation solutions for organ storage: a dynamic study of hepatic metabolism

Autor: K K, Changani, B J, Fuller, J D, Bell, S D, Taylor-Robinson, D P, Moore, B R, Davidson

Publikováno v: Transplantation. 68(3)

Organ cold storage times may be extended by modifications to organ preservation solutions.Three preservation solutions were investigated for their ability to maintain viable hepatic bioenergetics in stored pig livers: modified University of Wisconsin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b9c97bdaa77ff9c2221b03b2af3f7e7
https://pubmed.ncbi.nlm.nih.gov/10459537

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Incorporation of metabolite prior knowledge for data analysis: biochemical implications of dynamic 31P NMR ex vivo pig liver studies

Autor: K K, Changani, M, Ala-Korpela, B J, Fuller, S, Mierisova, D J, Bryant, S D, Taylor-Robinson, B R, Davidson, J D, Bell

Publikováno v: NMR in biomedicine. 12(4)

A semi-automated, metabolite prior-knowledge-based, lineshape fitting analysis has been developed to assess the dynamic biochemical changes found in ex vivo 31P NMR pig liver preservation studies. Due to the inherent experimental limitations of the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d2af33c6f431436f492d095441c59fe
https://pubmed.ncbi.nlm.nih.gov/10421911

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13C-Glycogen deposition during pregnancy in the rat following routine meal feeding

Autor: K K, Changani, J D, Bell, R A, Iles

Publikováno v: Biochimica et biophysica acta. 1380(2)

In vivo -NMR was employed to determine the hepatic fate of infused [1-]-d-glucose (200 mg/kg) following ad libitum or routine meal feeding (RMF) regimes imposed during pregnancy. Hepatic glycogen synthesis was measured immediately following the last

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ace33d0536542e1cfbce601c0182a10
https://pubmed.ncbi.nlm.nih.gov/9565686

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Non-invasive assessment of ATP regeneration potential of the preserved donor liver. A 31P MRS study in pig liver

Autor: K K, Changani, B J, Fuller, D J, Bryant, J D, Bell, M, Ala-Korpela, S D, Taylor-Robinson, D P, Moore, B R, Davidson

Publikováno v: Journal of hepatology. 26(2)

We have developed a quick, non-invasive method for measuring the ability of an isolated preserved liver to regenerate high energy phosphate nucleotides without the need for biopsy. Using 31P MRS we have monitored the hepatic energetics of intact cold

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::97a4b8371bc0d6f8ea09d4e34a4c7bde
https://pubmed.ncbi.nlm.nih.gov/9059955

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Hepatic nucleotide triphosphate regeneration after hypothermic reperfusion in the pig model: an in vitro P-NMR study

Autor: K K, Changani, B J, Fuller, J D, Bell, D J, Bryant, D P, Moore, S D, Taylor-Robinson, B R, Davidson

Publikováno v: Transplantation. 62(6)

The aim of this study was to assess the possibility of regenerating nucleotide triphosphates (NTP) in the pig liver following its harvest and subsequent storage on ice. This study has used a pig model that allowed human donor liver retrieval techniqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7b3fcbabfbe92289a9f7c1012d9de125
https://pubmed.ncbi.nlm.nih.gov/8824479

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