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Akademický článek

Enhancement of Mitochondrial Function by the Neurogenic Molecule NSI-189 Accompanies Reversal of Peripheral Neuropathy and Memory Impairment in a Rat Model of Type 2 Diabetes

Autor: C. G. Jolivalt, M. R. Aghanoori, M. C. Navarro-Diaz, M. M. Han, G. Sanchez, L. Guernsey, D. Quach, K. Johe, P. Fernyhough, N. A. Calcutt

Publikováno v: Journal of Diabetes Research, Vol 2022 (2022)

Aims. Mitochondrial dysfunction contributes to many forms of peripheral and central nervous system degeneration. Therapies that protect mitochondrial number and function have the potential to impact the progression of conditions such as diabetic neur

Externí odkaz: https://doaj.org/article/d1dccbfddcb4471ea66dabc8cf2a71cb

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Akademický článek

Stable Intracerebral Transplantation of Neural Stem Cells for the Treatment of Paralysis Due to Ischemic Stroke

Publikováno v: Stem Cells Translational Medicine, Vol 8, Iss 10, Pp 999-1007 (2019)

Abstract NSI‐566 is a stable, primary adherent neural stem cell line derived from a single human fetal spinal cord and expanded epigenetically with no genetic modification. This cell line is being tested in clinical trials in the U.S. for treatment

Externí odkaz: https://doaj.org/article/112c941a54514a309226862fde02f5f4

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Akademický článek

Transplantation of Human Fetal-Derived Neural Stem Cells Improves Cognitive Function following Cranial Irradiation

Autor: Munjal M. Acharya, Lori-Ann Christie, Thomas G. Hazel, Karl K. Johe, Charles L. Limoli

Publikováno v: Cell Transplantation, Vol 23 (2014)

Treatment of central nervous system (CNS) malignancies typically involves radiotherapy to forestall tumor growth and recurrence following surgical resection. Despite the many benefits of cranial radiotherapy, survivors often suffer from a wide range

Externí odkaz: https://doaj.org/article/a38a4452d72649958c35b8a531901062

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NSI-189 phosphate, a novel neurogenic compound, selectively benefits moderately depressed patients: A post-hoc analysis of a phase 2 study of major depressive disorder

Autor: Karl K, Johe, Gary, Kay, Santosh, Kumar, Katherine E, Burdick, Roger S, McIntyre, George I, Papakostas, Maurizio, Fava

Publikováno v: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. 32(3)

NSI-189 phosphate (NSI-189) is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ce0e4e2908bb1faa73ef69a94c1089d
https://pubmed.ncbi.nlm.nih.gov/32722729

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The neurogenic compound, NSI-189 phosphate: a novel multi-domain treatment capable of pro-cognitive and antidepressant effects

Autor: Carola Rong, Roger S. McIntyre, Yena Lee, Karl K Johe

Publikováno v: Expert Opinion on Investigational Drugs. 26:767-770

Alterations in neurogenic and neurotrophic processes as well as intracellular signalling cascades provides the basis for hypothesizing that neurogenic agents may be therapeutic across multiple RDoC-defined domains (e.g. positive valence systems, gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3df23e0a6e62ba4b2670f921aff449
https://doi.org/10.1080/13543784.2017.1324847

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Akademický článek

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A phase 2, double-blind, placebo-controlled study of NSI-189 phosphate, a neurogenic compound, among outpatients with major depressive disorder

Autor: P Russo, A Drouillard, George I. Papakostas, Max A. Martinson, H Hand, R Kashambwa, Bettina B. Hoeppner, Karl K Johe, G Kay, Martina Flynn, Albert Yeung, Maurizio Fava

Publikováno v: Molecular Psychiatry

NSI-189 is a novel neurogenic compound independent of monoamine reuptake pathways. This trial evaluated oral NSI-189 as monotherapy in major depressive disorder. To improve signal detection, the sequential-parallel comparison design (SPCD) was chosen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46293cd3290d08037a9dbe7db10c6c56
https://pubmed.ncbi.nlm.nih.gov/30626911

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A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients

Autor: John A. Bilello, Bradford C. Dickerson, Gustavo Kinrys, Linda M. Thurmond, Marlene P. Freeman, Bettina B. Hoeppner, David Mischoulon, K Johe, Larry Ereshefsky, Maurizio Fava, Martina Flynn, J Johnstone, L G Gertsik, Brett A. English, Nikos Makris

Publikováno v: Molecular Psychiatry

We wanted to examine tolerability and efficacy of NSI-189, a benzylpiperizine-aminiopyridine neurogenic compound for treating major depressive disorder (MDD). This was a Phase 1B, double blind, randomized, placebo controlled, multiple-dose study with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25b4fc6ebb87f3bb32943f0573d6db5
http://europepmc.org/articles/PMC5030464

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2 Biochemistry and molecular biology of MNSs blood group antigens

Autor: Sam Seifter, Cheng-Han Huang, Karl K. Johe, Olga O. Blumenfeld

Publikováno v: Baillière's Clinical Haematology. 4:821-848

This chapter has reviewed the nature of antigens of the MNSs blood group system. The structures of the proteins and the molecular features and organization of glycophorin genes were described, emphasizing their domain arrangement and the extensive se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74c93de5d6aef81e6bbd0f36e9e0049d
https://doi.org/10.1016/s0950-3536(06)80032-6

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