Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR

Autor: S. Kuschert, M. Stroet, Y. K.-Y. Chin, A. C. Conibear, X. Jia, T. Lee, C. R. O. Bartling, K. Strømgaard, P. Güntert, K. J. Rosengren, A. E. Mark, M. Mobli

Publikováno v: Magnetic Resonance, Vol 4, Pp 57-72 (2023)

Peptides and proteins containing non-canonical amino acids (ncAAs) are a large and important class of biopolymers. They include non-ribosomally synthesised peptides, post-translationally modified proteins, expressed or synthesised proteins containing

Externí odkaz: https://doaj.org/article/18e1d51764ce4a1196fed029911b7277

Buried treasure: biosynthesis, structures and applications of cyclic peptides hidden in seed storage albumins

Autor: K. J. Rosengren, Bastian Franke, Joshua S. Mylne

Publikováno v: Natural product reports. 35(2)

Covering: 1999 up to the end of 2017The small cyclic peptide SunFlower Trypsin Inhibitor-1 (SFTI-1) from sunflower seeds is the prototypic member of a novel family of natural products. The biosynthesis of these peptides is intriguing as their gene-en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe12fb8dcb095d79fa7b4c2005525e6c
https://pubmed.ncbi.nlm.nih.gov/29379937

Optimizing Nav1.7-Targeted Analgesics: Revealing Off-Target Effects of Spider Venom-Derived Peptide Toxins and Engineering Strategies for Improvement.

Autor: Luo S; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Zhou X; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Wu M; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Wang G; Henan Academy of Innovations in Medical science, Institute of Electrophysiology, Zhengzhou, Henan, 450000, China., Wang L; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Feng X; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Wu H; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Luo R; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Lu M; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Ju J; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Wang W; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Yuan L; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Luo X; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Peng D; Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials, School of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006, China., Yang L; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Zhang Q; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Chen M; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Liang S; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China., Dong X; Department of Research, Scope Research Institute of Electrophysiology, Kaifeng, 475004, China., Hao G; Henan Academy of Innovations in Medical science, Institute of Electrophysiology, Zhengzhou, Henan, 450000, China.; Department of Research, Scope Research Institute of Electrophysiology, Kaifeng, 475004, China., Zhang Y; Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials, School of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414006, China., Liu Z; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.; Peptide and small molecule drug R&D platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, 410081, China.; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Sep 09, pp. e2406656. Date of Electronic Publication: 2024 Sep 09.

Cumulative phylogenetic, sequence and structural analysis of Insulin superfamily proteins provide unique structure-function insights.

Autor: Rao SS; Division of Biological Sciences, Poornaprajna Institute of Scientific Research, Poornaprajnapura, 562110, Bidalur (Post), Bengaluru, India.; Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India., Kundapura SV; Division of Biological Sciences, Poornaprajna Institute of Scientific Research, Poornaprajnapura, 562110, Bidalur (Post), Bengaluru, India.; Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India., Dey D; Division of Biological Sciences, Poornaprajna Institute of Scientific Research, Poornaprajnapura, 562110, Bidalur (Post), Bengaluru, India.; Present address: Department of Biochemistry, Emory University School of Medicine, GA 30322, Atlanta, USA., Palaniappan C; Department of Computational and Data Sciences, Indian Institute of Science, 560012, Bangalore, India.; Molecular Biophysics Unit, Indian Institute of Science, 560012, Bangalore, India., Sekar K; Department of Computational and Data Sciences, Indian Institute of Science, 560012, Bangalore, India., Kulal A; Division of Biological Sciences, Poornaprajna Institute of Scientific Research, Poornaprajnapura, 562110, Bidalur (Post), Bengaluru, India., Ramagopal UA; Division of Biological Sciences, Poornaprajna Institute of Scientific Research, Poornaprajnapura, 562110, Bidalur (Post), Bengaluru, India.; Department of Microbiology and FST, School of Science, GITAM University, 530045, Visakhapatnam, India.

Publikováno v: Molecular informatics [Mol Inform] 2024 Sep; Vol. 43 (9), pp. e202300160. Date of Electronic Publication: 2024 Jul 08.

Phosphorylation of the HMGN1 Nucleosome Binding Domain Decreases Helicity and Interactions with the Acidic Patch.

Autor: Iebed D; Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9, 1060, Vienna, Austria., Gökler T; Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9, 1060, Vienna, Austria., van Ingen H; Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands., Conibear AC; Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9, 1060, Vienna, Austria.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Aug 26, pp. e202400589. Date of Electronic Publication: 2024 Aug 26.